<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">ksma</journal-id><journal-title-group><journal-title xml:lang="ru">Кубанский научный медицинский вестник</journal-title><trans-title-group xml:lang="en"><trans-title>Kuban Scientific Medical Bulletin</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1608-6228</issn><issn pub-type="epub">2541-9544</issn><publisher><publisher-name>Kuban State Medical University</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.25207/1608-6228-2018-25-6-184-191</article-id><article-id custom-type="elpub" pub-id-type="custom">ksma-1503</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОБЗОРЫ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>REVIEW</subject></subj-group></article-categories><title-group><article-title>ПОСЛЕОПЕРАЦИОННЫЙ ДЕЛИРИЙ: СОВРЕМЕННЫЕ АСПЕКТЫ ДИАГНОСТИКИ, ПРОФИЛАКТИКИ И ТЕРАПИИ</article-title><trans-title-group xml:lang="en"><trans-title>POSTOPERATIVE DELIRIUM: MODERN ASPECTS OF DIAGNOSIS, PREVENTION AND THERAPY</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Соколова</surname><given-names>М. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Sokolova</surname><given-names>M. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Проспект Троицкий, 51, Архангельск, Россия, 163000.</p></bio><bio xml:lang="en"><p>Troicki prospekt 51, Arkhangelsk, Russia, 163000.</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Киров</surname><given-names>М. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Kirov</surname><given-names>M. Y.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Проспект Троицкий, 51, Архангельск, Россия, 163000.</p></bio><bio xml:lang="en"><p>Troicki prospekt 51, Arkhangelsk, Russia, 163000.</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Шелыгин</surname><given-names>К. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Shelygin</surname><given-names>K. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Проспект Троицкий, 51, Архангельск, Россия, 163000.</p></bio><bio xml:lang="en"><p>Troicki prospekt 51, Arkhangelsk, Russia, 163000.</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Федеральное государственное бюджетное образовательное учреждение высшего образования «Северный государственный медицинский университет» Министерства здравоохранения Российской Федерации.</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Federal State Budgetary Educational Institution of Higher Education Northern State Medical University of the Ministry of Healthcare of the Russian Federation.</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2018</year></pub-date><pub-date pub-type="epub"><day>21</day><month>12</month><year>2018</year></pub-date><volume>25</volume><issue>6</issue><fpage>184</fpage><lpage>191</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Соколова М.М., Киров М.Ю., Шелыгин К.В., 2018</copyright-statement><copyright-year>2018</copyright-year><copyright-holder xml:lang="ru">Соколова М.М., Киров М.Ю., Шелыгин К.В.</copyright-holder><copyright-holder xml:lang="en">Sokolova M.M., Kirov M.Y., Shelygin K.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://ksma.elpub.ru/jour/article/view/1503">https://ksma.elpub.ru/jour/article/view/1503</self-uri><abstract><p>Делирий – острое изменение психического статуса в виде дезориентации во времени и пространстве, снижения внимания, нарушения режима сна/бодрствования. С психопатологической точки зрения, делирий – это качественное нарушение сознания, на фоне которого выявляются нарушения восприятия (иллюзии и галлюцинации). Послеоперационный делирий (ПОД) – одно из послеоперационных осложнений, возникающих у пациентов любого возраста, включая детей. Как правило, ПОД развивается в течение 5-7 дней после оперативного вмешательства. На сегодняшний день в мире ежегодно проводится более 230 миллионов оперативных вмешательств, при этом частота ПОД варьирует в зависимости от типа хирургических операций, возраста и целого ряда факторов риска. Последствия ПОД включают в себя когнитивные расстройства, продление сроков лечения, госпитализации и повышение летальности, что ведет к значимому увеличению затрат системы здравоохранения. Внедрение протокола по диагностике и терапии делирия, основанного на современных рекомендациях, может улучшить клинический исход.</p></abstract><trans-abstract xml:lang="en"><p>Delirium is an acute change in mental status in the form of disorientation in time and space, loss of attention and disruption of sleep/wake patterns. From the psychopathological point of view, delirium is a qualitative disorder of consciousness with concomitant disorders of perception (illusions and hallucinations). Postoperative delirium (POD) is one of the postoperative complications that occur in patients of any age, including children. As a rule, POD develops within 5-7 days after the surgery. The frequency of its occurrence varies in different age groups. Nowadays more than 230 million surgeries are performed annually in the world, and the frequency of POD depends on the type of surgical operations, age of a patient and a number of risk factors. The effects of POD include cognitive disorders, prolonged hospitalization, increased mortality, leading to a significant increase in healthcare costs. The implementation of the protocol on the diagnosis and therapy of delirium, based on modern recommendations, can improve the clinical outcome.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>послеоперационный делирий</kwd><kwd>когнитивная дисфункция</kwd></kwd-group><kwd-group xml:lang="en"><kwd>postoperative delirium</kwd><kwd>cognitive dysfunction</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">. 1. Weiss B., Spies C.D. et all. European Society of Anaesthesi-ology evidence-based and consensus-based guideline on postop-erative delirium. Eur. J. Anaesthesiol. 2017; 34: 192-214.</mixed-citation><mixed-citation xml:lang="en">Weiss B., Spies C.D. et all. European Society of Anaesthesi-ology evidence-based and consensus-based guideline on postop-erative delirium. Eur. J. Anaesthesiol. 2017; 34: 192-214.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Лихванцев В.В., Улиткина О.Н., Резепов Н.А. Послеопе-рационный делирий: что нового предлагает нам новое руковод-ство ESA-2017? Вестник анестезиологии и реаниматологии. 2017; 14(2): 41-47.</mixed-citation><mixed-citation xml:lang="en">Likhvantsev V.V., Ulitkina O.N., Rezepov N.A. Postoperative delirium: what new does novel guidelines by ESA- 2017 offer? Messenger of anesthesiology and resuscitation. 2017; 14(2): 41-47. (In Russ., English abstract).</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Острые психотические расстройства в интенсивной те-рапии: Практическое руководство для анестезиологов-реа- ниматологов, хирургов, неврологов и психиатров. Под ред. акад. РАН проф. Б.РГельфанда и проф. В.Н.Краснова. М.: ООО «Издательство «Медицинское информационное агент¬ство», 2014. 232 с.</mixed-citation><mixed-citation xml:lang="en">Ostrye psihoticheskie rasstrojstva v intensivnoj terapii: Prakticheskoe rukovodstvo dlya anesteziologov-reani- matologov, hirurgov, nevrologov i psihiatrov. Pod red. akad. RAN prof. B.R.Gel'fanda i prof. V.N.Krasnova. M.: OOO «Izdatel'stvo «Medicinskoe informacionnoe agentstvo», 2014. 232 s. (In Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Федеральные клинические рекомендации по диагностике и лечению абстинентного состояния с делирием, вызванного употреблением психоактивных веществ Российское общество психиатров. 2014 г.</mixed-citation><mixed-citation xml:lang="en">Federal'nye klinicheskie rekomendacii po diagnostike i lecheniyu abstinentnogo sostoyaniya s deliriem, vyzvannogo upotrebleniem psihoaktivnyh veshchestv Rossijskoe obshchestvo psihiatrov. 2014 g. (In Russ.).</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Jaspers К. Allgemeine. Psychopathologie. Berlin. 1929.</mixed-citation><mixed-citation xml:lang="en">Jaspers К. Allgemeine. Psychopathologie. Berlin. 1929.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Peitz G.J., Balas M.C., Olsen K.M., Pun B.T., Ely E.W. Top 10 myths regarding sedation and delirium in the ICU. Crit. Care Med. 2013; 41: 46-56.</mixed-citation><mixed-citation xml:lang="en">Peitz G.J., Balas M.C., Olsen K.M., Pun B.T., Ely E.W. Top 10 myths regarding sedation and delirium in the ICU. Crit. Care Med. 2013; 41: 46-56.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Reade M.C., Finfer S. Sedation and delirium in the intensive care unit. N. Engl. J. Med. 2014; 370: 454.</mixed-citation><mixed-citation xml:lang="en">Reade M.C., Finfer S. Sedation and delirium in the intensive care unit. N. Engl. J. Med. 2014; 370: 454.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Nilsson M, Sonne C. Diagnostics and treatment of Wernicke-Korsakoff syndrome patients with an alcohol abuse. Ugeskr Laeger. 2013; 175 (14): 942-944.</mixed-citation><mixed-citation xml:lang="en">Nilsson M, Sonne C. Diagnostics and treatment of Wernicke-Korsakoff syndrome patients with an alcohol abuse. Ugeskr Laeger. 2013; 175 (14): 942-944.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Сиволап Ю.П., Дамулин И.В. Синдром Вернике-Корсако-ва. Неврология, нейропсихиатрия, психосоматика. 2014; 6(4): 76-80.</mixed-citation><mixed-citation xml:lang="en">Sivolap Y.P., Damulin I.V. Wernicke-Korsakoff syndrome. Neurology, Neuropsychiatry, Psychosomatics. 2014; 6 (4): 76-80. (In Russ., English abstract)].</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Semple D., Smyth R. Oxford Handbook of Psychiatry Ox-ford: Oxford University Press. 2013: 1057.</mixed-citation><mixed-citation xml:lang="en">Semple D., Smyth R. Oxford Handbook of Psychiatry Ox-ford: Oxford University Press. 2013: 1057.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Ahmed S., Murugan R. Dexmedetomidine use in the ICU: are we there yet? Crit. Care. 2013; 17: 320.</mixed-citation><mixed-citation xml:lang="en">Ahmed S., Murugan R. Dexmedetomidine use in the ICU: are we there yet? Crit. Care. 2013; 17: 320.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Latronico N. Haloperidol and delirium in the ICU: the fin¬ger pointing to the moon. Intensive Care Med. 2018 Jun 23 [Epub ahead of print].</mixed-citation><mixed-citation xml:lang="en">Latronico N. Haloperidol and delirium in the ICU: the fin¬ger pointing to the moon. Intensive Care Med. 2018 Jun 23 [Epub ahead of print].</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Treatment of alcohol withdrawal delirium. WHO, 2012. http://urlid.ru/bbew</mixed-citation><mixed-citation xml:lang="en">Treatment of alcohol withdrawal delirium. WHO, 2012. http://urlid.ru/bbew</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Nguyen J., Nacpil N. Effectiveness of dexmedetomidine versus propofol on extubation times, length of stay and mortality rates in adult cardiac surgery patients: a systematic review and meta-analysis. JBI Database System Rev. Implement Rep. 2018; 16(5): 1220-1239.</mixed-citation><mixed-citation xml:lang="en">Nguyen J., Nacpil N. Effectiveness of dexmedetomidine versus propofol on extubation times, length of stay and mortality rates in adult cardiac surgery patients: a systematic review and meta-analysis. JBI Database System Rev. Implement Rep. 2018; 16(5): 1220-1239.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Marcantonio E.R. Marcantonio E.R. Delirium in hospital¬ized older adults. N. Engl. J. Med. 2017; 377: 1456-1466.</mixed-citation><mixed-citation xml:lang="en">Marcantonio E.R. Marcantonio E.R. Delirium in hospital¬ized older adults. N. Engl. J. Med. 2017; 377: 1456-1466.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Barnes-Daly M.A., Phillips G., Ely E.W. Improving hospital survival and reducing brain dysfunction at seven California community hospitals: implementing PAD guidelines via the ABCDEF bundle in 6,064 Patients. Crit. Care. Med. 2017; 45: 171¬178.</mixed-citation><mixed-citation xml:lang="en">Barnes-Daly M.A., Phillips G., Ely E.W. Improving hospital survival and reducing brain dysfunction at seven California community hospitals: implementing PAD guidelines via the ABCDEF bundle in 6,064 Patients. Crit. Care. Med. 2017; 45: 171¬178.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Kang J., Lee M., Ko H. et all. Effect of nonpharmacologi¬cal interventions for the prevention of delirium in the intensive care unit: A systematic review and meta-analysis. J. Crit. Care. 2018; 48: 372-384.</mixed-citation><mixed-citation xml:lang="en">Kang J., Lee M., Ko H. et all. Effect of nonpharmacologi¬cal interventions for the prevention of delirium in the intensive care unit: A systematic review and meta-analysis. J. Crit. Care. 2018; 48: 372-384.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Zoremba N., Coburn M., Schalte G. Delirium in intensive care patients: A multiprofessional challenge. Anaesthesist. 2018; Oct 8. [Epub ahead of print].</mixed-citation><mixed-citation xml:lang="en">Zoremba N., Coburn M., Schalte G. Delirium in intensive care patients: A multiprofessional challenge. Anaesthesist. 2018; Oct 8. [Epub ahead of print].</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Thomson A.D. Guerrini I., Marshall E.J. The evolution and treatment of Korsakoff's syndrome: out of sight, out of mind? Neu- ropsychol. rev. 2012; 22: 81-92.</mixed-citation><mixed-citation xml:lang="en">Thomson A.D. Guerrini I., Marshall E.J. The evolution and treatment of Korsakoff's syndrome: out of sight, out of mind? Neu- ropsychol. rev. 2012; 22: 81-92.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Flukiger J., Hollinger A., Speich B. et. all. Dexmedetomi¬dine in prevention and treatment of postoperative and intensive care unit delirium: a systematic review and meta-analysis. Ann. Intensive Care. 2018; 8(1): 92.</mixed-citation><mixed-citation xml:lang="en">Flukiger J., Hollinger A., Speich B. et. all. Dexmedetomi¬dine in prevention and treatment of postoperative and intensive care unit delirium: a systematic review and meta-analysis. Ann. Intensive Care. 2018; 8(1): 92.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Ng K.T., Shubash C.J., Chong J.S. The effect of dexme- detomidine on delirium and agitation in patients in intensive care: systematic review and meta-analysis with trial sequential analysis. Anaesthesia. 2018 Oct . [Epub ahead of print].</mixed-citation><mixed-citation xml:lang="en">Ng K.T., Shubash C.J., Chong J.S. The effect of dexme- detomidine on delirium and agitation in patients in intensive care: systematic review and meta-analysis with trial sequential analysis. Anaesthesia. 2018 Oct . [Epub ahead of print].</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
