ksmaКубанский научный медицинский вестникKuban Scientific Medical Bulletin1608-62282541-9544Kuban State Medical University10.25207/1608-6228-2019-26-3-108-116ksma-1787Research ArticleОБЗОРЫREVIEWПЕРСПЕКТИВЫ ПРИМЕНЕНИЯ СУПРАМОЛЕКУЛЯРНЫХ ГЕЛЕЙ В ЭКСПЕРИМЕНТАЛЬНОЙ ХИРУРГИИPROSPECTS OF THE APPLICATION OF SUPRAMOLECULAR GELS IN EXPERIMENTAL SURGERYВалиевТ. М.ValievTimur M.

аспирант по программе аспирантуры (направленность «Хирургия»),

ул. Советская, д. 4, г. Тверь, 170000;

тел.: +7 (904) 008-97-21

 

PhD student,

Sovetskaya str., 4, Tver, 170000;

tel: +7 (904) 008-97-21

t.m.valiev@yandex.ruПетроваМ. Б.PetrovaMargarita B.

доктор биологических наук, профессор, заведующая кафедрой биологии,

ул. Советская, д. 4, г. Тверь, 170000

Dr. Sci. (Med.), Prof., Departmental Head, Department of Biology,

Sovetskaya str., 4, Tver, 170000

МоховЕ. М.MokhovEvgeny M.

доктор медицинских наук, профессор, заведующий кафедрой общей хирургии,

ул. Советская, д. 4, г. Тверь, 170000

Dr. Sci. (Med.), Prof., Departmental Head, Department of General Surgery,

Sovetskaya str., 4, Tver, 170000

Федеральное государственное бюджетное образовательное учреждение высшего образования «Тверской государственный медицинский университет» Министерства здравоохранения Российской ФедерацииРоссияTver State Medical University, Ministry of Healthcare of the Russian FederationRussian Federation201906072019263108116Copyright © Валиев Т.М., Петрова М.Б., Мохов Е.М., 20192019Валиев Т.М., Петрова М.Б., Мохов Е.М.Valiev T.M., Petrova M.B., Mokhov E.M.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://ksma.elpub.ru/jour/article/view/1787

Цель: проблемно-критический анализ влияния супрамолекулярных гелей на течение заживления экспериментальных ран. Материалы. Использованы 29 источников отечественной и зарубежной литературы, включенных в базы данных РИНЦ (elibrary, режим «Расширенный поиск»), Scopus (режим «Названия статей, аннотации, ключевые слова»), Web of Science (базовый режим), PubMed (режим базового поиска), Cochrane (режим «Названия статей, аннотации, ключевые слова»). Результаты. В статье проводится систематизация литературных данных об изученных супрамолекулярных гелях в аспекте регенерации и репарации ран. Заключение. Повреждения кожи и глубжележащих тканей человека являются актуальной проблемой медицины, что обусловливает постоянный поиск средств для стимуляции регенерации ран. Супрамолекулярные гели представляют собой перспективные соединения, которые могут быть различными по химическому составу, образовываться и разрушаться под влиянием определенных химико-физических факторов. Важными свойствами супрамолекулярных гелей являются возможность выполнения транспортной функции по доставке биологически активных веществ к тканям, антибактериальный эффект, а также ранозаживляющие свойства.

Aim. To analyse the effect of supramolecular gels on the healing of experimental wounds using the approaches of problem-critical analysis. Materials. 29 Russian and foreign publications indexed in RSCI (E-library, “Advanced Search” mode), Scopus (“Article title, abstracts, keywords”), Web of Science (basic mode), PubMed (basic search mode), Cochrane (“Article title, abstracts, keywords” mode) databases were analysed. Results. Generalization of literature data published on the application of supramolecular gels under analysis for wound regeneration and repair was carried out. Conclusion. Damage to the skin and deeper tissues is an urgent medical problem, which leads to a constant search for means to stimulate the regeneration of wounds. Supramolecular gels are promising compounds, which can be different in terms of chemical composition. These compounds can form and break down under the influence of various chemical and physical factors. Important properties of supramolecular gels involve the ability to perform the transport function for the delivery of biologically active substances to the tissues, as well as their antibacterial effect and wound-healing properties.

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The authors declare that there are no conflicts of interest present.