ksmaКубанский научный медицинский вестникKuban Scientific Medical Bulletin1608-62282541-9544Kuban State Medical University10.25207/1608-6228-2019-26-4-123-130ksma-1865Research ArticleОБЗОРЫREVIEWЛепра: современные представления о путях передачиLeprosy: Modern Views on the Modes of its TransmissionЯнчевскаяЕ. Ю.YanchevskayaE. Yu.

Янчевская Елена Юрьевна — кандидат медицинских наук, доцент, доцент кафедры дерматовенерологии

ул. Бакинская, д. 121, г. Астрахань, 414000

Elena Yu. Yanchevskaya — Cand. Sci. (Med.), Assoc. Prof., Department of Dermatovenerology

Bakinskaya str., 121, Astrakhan, 414000

МеснянкинаО. А.MesnyankinaO. A.

Меснянкина Ольга Александровна — кандидат медицинских наук, ассистент кафедры дерматовенерологии

ул. Бакинская, д. 121, г. Астрахань, 414000

Olga A. Mesnyankina — Cand. Sci. (Med.), Research Assistant, Department of Dermatovenerology

Bakinskaya str., 121, Astrakhan, 414000

olga_mesnyankina@mail.ruФедеральное государственное бюджетное образовательное учреждение высшего образования «Астраханский государственный медицинский университет» Министерства здравоохранения Российской ФедерацииРоссияAstrakhan State Medical UniversityRussian Federation201915092019264123130Copyright © Янчевская Е.Ю., Меснянкина О.А., 20192019Янчевская Е.Ю., Меснянкина О.А.Yanchevskaya E.Y., Mesnyankina O.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://ksma.elpub.ru/jour/article/view/1865

В статье обобщены имеющиеся представления об источниках и путях передачи лепры. Детально раскрыта эволюция взглядов на проблему возникновения и механизма передачи инфекции. Особое внимание уделено современным направлениям научных исследований и актуальным достижениям современной лепрологии.

The present article summarises existing ideas about the sources of leprosy and the modes of its transmission. The authors cover the evolution of views on the origin of this infection along with the mechanism underlying its transmission. Special attention is paid to modern research trends and current achievements in the sphere of modern leprology.

лепраMycobacterium lepraeпути передачиleprosyMycobacterium lepraetransmission modeReferencesДегтярев О.В., Иншина Е.А., Метревели Г.В., Янчевская Е.Ю. Рецидивы лепры. Астраханский медицинский журнал. 2015; 10(3): 6–14.Degtyarev O.V., Inshina E.A., Metreveli G.V., Yanchevskaya E.Yu. Leprosy relapses. Astrakhanskii Meditsinskii Zhurnal. 2015; 10(3): 6–14. (In Russ., English abstract).Меснянкина О.А., Дуйко В.В. Качество жизни и особенности ведения больных лепрой. Российский журнал кожных и венерических болезней. 2013; 2: 55–58.Mesnyankina O.A., Duiko V.V. Quality of life and treatment of patients with leprosy. Rossiiskii Zhurnal Kozhnykh i Venericheskikh Boleznei. 2013; 2: 55–58. (In Russ., English abstract).Меснянкина О.А. Совершенствование диагностики осложнений лепрозного процесса: автореф. дис. … канд. мед. наук. М., 2010. 26 с.Mesnyankina O.A. Sovershenstvovanie diagnostiki oslozhnenii leproznogo protsessa [Improving the diagnosis of complications of the leprosy process]: Extended abstract of Cand. Med. Sci. dissertation. Moscow, 2010. 26 р. (In Russ.).Дуйко В.В. Основные направления организации медико-социальной помощи больным лепрой в современных условиях: автореф. дис. … д-ра мед. наук. М., 2013. 48 с.Duiko.V.V. Osnovnye napravleniya organizatsii medikosotsial’noi pomoshchi bol’nym leproi v sovremennykh usloviyakh [The main directions of the organization of medical and social care for leprosy patients in modern conditions]: Extended abstract of Doct. Med. Sci. dissertation. Moscow, 2013. 48 р. (In Russ.).Rees R.J.W., Meade T.W. Comparison of the modes of spread and the incidence of tuberculosis and leprosy. Lancet. 1974; 303(7846): 47–48. DOI: 10.1016/S0140-6736(74)93043-8Rees R.J.W., Meade T.W. Comparison of the modes of spread and the incidence of tuberculosis and leprosy. Lancet. 1974; 303(7846): 47–48. DOI: 10.1016/S0140-6736(74)93043-8Shepard C.C. Acid-fast bacilli in nasal excretions in leprosy, and results of inoculation of mice. Am. J. Hyg. 1960; 71:147–157.Shepard C.C. Acid-fast bacilli in nasal excretions in leprosy, and results of inoculation of mice. Am. J. Hyg. 1960; 71:147–157.Pedley J.C. The nasal mucus in leprosy. Lepr. Rev. 1973; 44(1): 33–35.Pedley J.C. The nasal mucus in leprosy. Lepr. Rev. 1973; 44(1): 33–35.Davey T.F., Rees R.J. The nasal dicharge in leprosy: clinical and bacteriological aspects. Lepr. Rev. 1974; 45(2):121–134.Davey T.F., Rees R.J. The nasal dicharge in leprosy: clinical and bacteriological aspects. Lepr. Rev. 1974; 45(2):121–34.Olcén P., Harboe M., Warndorff van Diepen T. Antigens of Mycobacterium leprae in urine during treatment of patients with lepromatous leprosy. Lepr. Rev. 1986; 57(4): 329–340.Olcén P., Harboe M., Warndorff van Diepen T. Antigens of Mycobacterium leprae in urine during treatment of patients with lepromatous leprosy. Lepr. Rev. 1986; 57(4): 329–340.Скрипкин Ю.К., Кубанова А.А., Акимов В.Г. Кожные и венерические болезни. М.: ГЭОТАР-Медиа, 2009; 544 с.Skripkin Yu.K., Kubanova A.A., Akimov V.G. Kozhnye i venericheskie bolezni [Skin and venereal diseases]. Moscow: GEOTAR-Media, 2009; 544 р. (In Russ.).Abraham S., Mozhi N.M., Joseph G.A., Kurian N., Sundar Rao S.S., Job C.K. Epidemiological signifi cance of fi rst skin lesion in leprosy. Int. J. Lepr. 1998; 66(2): 131–139.Abraham S., Mozhi N.M., Joseph G.A., Kurian N., Sundar Rao S.S., Job C.K. Epidemiological signifi cance of fi rst skin lesion in leprosy. Int. J. Lepr. 1998; 66(2): 131–139.Duncan M.E., Melsom R., Pearson J.M., Menzel S., Barnetson R.S. A clinical and immunological study of four babies of mothers with lepromatous leprosy, two of whom developed leprosy in infancy. Int. J. Lepr. Other Mycobact. Dis. 1983; 51(1): 7–17.Duncan M.E., Melsom R., Pearson J.M., Menzel S., Barnetson R.S. A clinical and immunological study of four babies of mothers with lepromatous leprosy, two of whom developed leprosy in infancy. Int. J. Lepr. Other Mycobact. Dis. 1983; 51(1): 7–17.Job C.K., Sanchez R.M., Hastings R.C. Lepromatous placentitis and intrauterine fetal infection in lepromatous nine-banded armadillos (Dasypus novemcinctus). Lab. Invest. 1987; 56(1): 44–48.Job C.K., Sanchez R.M., Hastings R.C. Lepromatous placentitis and intrauterine fetal infection in lepromatous nine-banded armadillos (Dasypus novemcinctus). Lab. Invest. 1987; 56(1): 44–48.Рубинс А. Дерматовенерология. М.: Издательство Панфилова, 2011; 368 с.Rubins A. Dermatovenerologiya [Dermatovenerology]. M.: Izdatel’stvo Panfi lova, 2011; 368 р. (In Russ.).Pedley J.C. The presence of M. leprae in human milk. Lepr. Rev. 1967; 38(4): 239–242.Pedley J.C. The presence of M. leprae in human milk. Lepr. Rev. 1967; 38(4): 239–242.Huang C.L-H. The transmission of leprosy in man. Int. J. Lepr. Other Mycobact. Dis. 1980; 48(3): 309–318.Huang C.L-H. The transmission of leprosy in man. Int. J. Lepr. Other Mycobact. Dis. 1980; 48(3): 309–318.Storrs E.E., Walsh G.P., Burchfi eld H.P., Binford C.H. Leprosy in the armadillo: new model for biomedical research. Science. 1974; 183(4127): 851–852.Storrs E.E., Walsh G.P., Burchfi eld H.P., Binford C.H. Leprosy in the armadillo: new model for biomedical research. Science. 1974; 183(4127): 851–852.Trindade M.A., Manini M.I., Masetti J.H., Leite M.A., Takahashi M.D., Naafs B. Leprosy and HIV co-infection in fi ve patients. Lepr. Rev. 2005; 76(2): 162–166.Trindade M.A., Manini M.I., Masetti J.H., Leite M.A., Takahashi M.D., Naafs B. Leprosy and HIV co-infection in fi ve patients. Lepr. Rev. 2005; 76(2): 162–166.Scollard D.M., Adams L.B., Gillis T.P., Krahenbuhl J.L., Truman R.W., Williams D.L.The continuing challenges of leprosy. Clin. Microbiol. Rev. 2006; 19(2): 338–381.Scollard D.M., Adams L.B., Gillis T.P., Krahenbuhl J.L., Truman R.W., Williams D.L. The continuing challenges of leprosy. Clin. Microbiol. Rev. 2006; 19(2): 338–381.Truman R.W., Singh P., Sharma R., Busso P., Rougemont J., Paniz-Mondolfi A., Kapopoulou A., Brisse S., Scollard D.M., Gillis T.P., Cole S.T. Probable zoonotic leprosy in the southern United States. N. Engl. J. Med. 2011; 364(17): 1626–1633.Truman R.W., Singh P., Sharma R., Busso P., Rougemont J., Paniz-Mondolfi A., Kapopoulou A., Brisse S., Scollard D.M., Gillis T.P., Cole S.T. Probable zoonotic leprosy in the southern United States. N. Engl. J. Med. 2011; 364(17): 1626–1633.Balamayooran G., Pena M., Sharma R., Truman R.W. The armadillo as an animal model and reservoir host for Mycobacterium leprae. Clin. Dermatol. 2015; 33(1): 108–115.Balamayooran G., Pena M., Sharma R., Truman R.W. The armadillo as an animal model and reservoir host for Mycobacterium leprae. Clin. Dermatol. 2015; 33(1): 108–115.Scollard D.M., Truman R.W., Ebenezer G.J. Mechanisms of nerve injury in leprosy. Clin. Dermatol. 2015; 33(1): 46–54.Scollard D.M., Truman R.W., Ebenezer G.J. Mechanisms of nerve injury in leprosy. Clin. Dermatol. 2015; 33(1): 46–54.Rojas-Espinosa O., Lovik M. Mycobacterium leprae and Mycobacterium lepraemurium infections in domestic and wild animals. Rev. Sci. Tech. 2001; 20(1): 219–251.Rojas-Espinosa O., Lovik M. Mycobacterium leprae and Mycobacterium lepraemurium infections in domestic and wild animals. Rev. Sci. Tech. 2001; 20(1): 219–251.Honap T.P., Pfi ster L.A., Housman G., Mills S., Tarara R.P, Suzuki K., Cuozzo F.P., Sauther M.L., Rosenberg M.S., Stone A.C. Mycobacterium leprae genomes from naturally infected nonhuman primates. PLoS Negl. Trop. Dis. 2018; 12(1): e0006190. DOI: 10.1371/journal.pntd.0006190Honap T.P., Pfi ster L.A., Housman G., Mills S., Tarara R.P, Suzuki K., Cuozzo F.P., Sauther M.L., Rosenberg M.S., Stone A.C. Mycobacterium leprae genomes from naturally infected nonhuman primates. PLoS Negl. Trop. Dis. 2018; 12(1): e0006190. DOI: 10.1371/journal.pntd.0006190Shepard C.C. Multiplication of Mycobacterium leprae in the foot-pad of the mouse. Int. J. Lepr. 1962; 30: 291–306.Shepard C.C. Multiplication of Mycobacterium leprae in the foot-pad of the mouse. Int. J. Lepr. 1962; 30: 291–306.Rojas-Espinosa O., Lovik M. Mycobacterium leprae and Mycobacterium lepraemurium infections in domestic and wild animals. Rev. Sci. Tech. 2001; 20(1): 219–251.Rojas-Espinosa O., Lovik M. Mycobacterium leprae and Mycobacterium lepraemurium infections in domestic and wild animals. Rev. Sci. Tech. 2001; 20(1): 219–251.Trombone A.P., Pedrini S.C., Diório S.M., Belone Ade F., Fachin L.R., do Nascimento D.C., Rosa P.S. Optimized protocols for Mycobacterium leprae strain management: frozen stock preservation and maintenance in athymic nude mice. J. Vis. Exp. 2014; 85: e50620. DOI:10.3791/50620Trombone A.P., Pedrini S.C., Diório S.M., Belone Ade F., Fachin L.R., do Nascimento D.C., Rosa P.S. Optimized protocols for Mycobacterium leprae strain management: frozen stock preservation and maintenance in athymic nude mice. J. Vis. Exp. 2014; 85: e50620. DOI:10.3791/50620Кацамбаса А.Д, Лотти Т.М. Европейское руководство по лечению дерматологических заболеваний. М.: МЕДпресс-информ, 2014; 736 с.Katsambasa A.D, Lotti T.M. Evropeiskoe rukovodstvo po lecheniyu dermatologicheskikh zabolevanii [European guidelines for the treatment of dermatological diseases]. Moscow: MEDpress-inform, 2014; 736 р. (In Russ.).Juarez-Ortega M., Hernandez V.G., Arce-Paredes P., Villanueva E.B., Aguilar-Santelises M., RojasEspinosa O. Induction and treatment of anergy in murine leprosy. Int. J. Exp. Pathol. 2015; 96(1): 31–41. DOI: 10.1111/iep.12108Juarez-Ortega M., Hernandez V.G., Arce-Paredes P., Villanueva E.B., Aguilar-Santelises M., RojasEspinosa O. Induction and treatment of anergy in murine leprosy. Int. J. Exp. Pathol. 2015; 96(1): 31–41. DOI: 10.1111/iep.12108Geater J.G. The fl y as potential vector in the transmission of leprosy. Lepr. Rev. 1975; 46(4): 279–286.Geater J.G. The fl y as potential vector in the transmission of leprosy. Lepr. Rev. 1975; 46(4): 279–286.Mohanty P.S., Naaz F., Katara D., Misba L., Kumar D., Dwivedi D.K., Tiwari A.K., Chauhan D.S., Bansal A.K., Tripathy S.P., Katoch K. Viability of Mycobacterium leprae in the environment and its role in leprosy dissemination. Indian J. Dermatol. Venereol. Leprol. 2016; 82(1): 23–27. DOI: 10.4103/0378-6323.168935Mohanty P.S., Naaz F., Katara D., Misba L., Kumar D., Dwivedi D.K., Tiwari A.K., Chauhan D.S., Bansal A.K., Tripathy S.P., Katoch K. Viability of Mycobacterium leprae in the environment and its role in leprosy dissemination. Indian J. Dermatol. Venereol. Leprol. 2016; 82(1): 23–27. DOI: 10.4103/03786323.168935Tió-Coma M., Wijnands T., Pierneef L., Schilling A.K., Alam K., Roy J.C., Faber W.R., Menke H., Pieters T., Stevenson K., Richardus J.H., Geluk A.. Detection of Mycobacterium leprae DNA in soil: multiple needles in the haystack. Sci. Rep. 2019; 9(1): 3165. DOI: 10.1038/s41598-019-39746-6Tió-Coma M., Wijnands T., Pierneef L., Schilling A.K., Alam K., Roy J.C., Faber W.R., Menke H., Pieters T., Stevenson K., Richardus J.H., Geluk A.. Detection of Mycobacterium leprae DNA in soil: multiple needles in the haystack. Sci. Rep. 2019; 9(1): 3165. DOI: 10.1038/s41598-019-39746-6Holanda M.V., Marques L.E.C., Macedo M.L.B., Pontes M.A.A., Sabadia J.A.B., Kerr L.R.F.S., Almeida R.L.F., Frota C.C. Presence of Mycobacterium leprae genotype 4 in environmental waters in Northeast Brazil. Rev. Soc. Bras. Med. Trop. 2017; 50(2): 216–222. DOI: 10.1590/0037-8682-0424-2016Holanda M.V., Marques L.E.C., Macedo M.L.B., Pontes M.A.A., Sabadia J.A.B., Kerr L.R.F.S., Almeida R.L.F., Frota C.C. Presence of Mycobacterium leprae genotype 4 in environmental waters in Northeast Brazil. Rev. Soc. Bras. Med. Trop. 2017; 50(2): 216– 222. DOI: 10.1590/0037-8682-0424-2016Arraes M.L.B.M., Holanda M.V., Lima L.N.G.C., Sabadia J.A.B., Duarte C.R., Almeida R.L.F., Kendall C., Kerr L.R.S., Frota C.C. Natural environmental water sources in endemic regions of northeastern Brazil are potential reservoirs of viable Mycobacterium leprae. Mem. Inst. Oswaldo. Cruz. 2017;112(12): 805–811. DOI: 10.1590/0074-02760170117Arraes M.L.B.M., Holanda M.V., Lima L.N.G.C., Sabadia J.A.B., Duarte C.R., Almeida R.L.F., Kendall C., Kerr L.R.S., Frota C.C. Natural environmental water sources in endemic regions of northeastern Brazil are potential reservoirs of viable Mycobacterium leprae. Mem. Inst. Oswaldo. Cruz. 2017;112(12): 805–811. DOI: 10.1590/0074-02760170117Lahiri R., Krahenbuhl J.L.The role of free-living pathogenic amoeba in the transmission of leprosy: a proof of principle. Lepr. Rev. 2008; 79(4): 401–409.Lahiri R., Krahenbuhl J.L.The role of free-living pathogenic amoeba in the transmission of leprosy: a proof of principle. Lepr. Rev. 2008; 79(4): 401–409.Turankar R.P., Lavania M., Darlong J., Siva Sai K.S.R., Sengupta U., Jadhav R.S. Survival of Mycobacterium leprae and association with Acanthamoeba from environmental samples in the inhabitant areas of active leprosy cases: A cross sectional study from endemic pockets of Purulia, West Bengal. Infect. Genet. Evol. 2019; pii: S1567– 1348(19)30001-2. DOI: 10.1016/j.meegid.2019.01.014Turankar R.P., Lavania M., Darlong J., Siva Sai K.S.R., Sengupta U., Jadhav R.S. Survival of Mycobacterium leprae and association with Acanthamoeba from environmental samples in the inhabitant areas of active leprosy cases: A cross sectional study from endemic pockets of Purulia, West Bengal. Infect. Genet. Evol. 2019; pii: S1567–1348(19)30001-2. DOI: 10.1016/j.meegid.2019.01.014

The authors declare that there are no conflicts of interest present.