<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">ksma</journal-id><journal-title-group><journal-title xml:lang="ru">Кубанский научный медицинский вестник</journal-title><trans-title-group xml:lang="en"><trans-title>Kuban Scientific Medical Bulletin</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1608-6228</issn><issn pub-type="epub">2541-9544</issn><publisher><publisher-name>Kuban State Medical University</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.25207/1608-6228-2022-29-5-123-136</article-id><article-id custom-type="elpub" pub-id-type="custom">ksma-2732</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>КРАТКИЕ СООБЩЕНИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>BRIEF COMMUNICATIONS</subject></subj-group></article-categories><title-group><article-title>Состояние вегетативной регуляции у больных с ишемическим инсультом в острейшем и остром периодах: наблюдательное когортное исследование</article-title><trans-title-group xml:lang="en"><trans-title>The State of Vegetative Regulation in Patients with Ischemic Stroke in the Acute and Peracute Periods: an Observational Cohort Study</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-2285-7705</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Чекеева</surname><given-names>Н. Т.</given-names></name><name name-style="western" xml:lang="en"><surname>Chekeeva</surname><given-names>N. T.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Чекеева Наргиза Токтогуловна — врач-невролог</p><p>ул. Тоголок Молдо, д. 1, г. Бишкек, 720040</p></bio><bio xml:lang="en"><p>Nargiza T. Chekeeva — Neurologist </p><p>Togolok Moldo str. 1, Bishkek, 720001</p></bio><email xlink:type="simple">chekeeva.n@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-1437-7696</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Шлейфер</surname><given-names>С. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Shleifer</surname><given-names>S. G.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Шлейфер Светлана Григорьевна — кандидат медицинских наук, доцент; ответственная за НИРС кафедры неврологии, нейрохирургии и медицинской генетики</p><p>ул. Киевская, д. 44, г. Бишкек, 720000</p></bio><bio xml:lang="en"><p>Svetlana G. Shleifer — Cand. Sci. (Med.), Assoc. Prof.; Students’ Scientific Research Responsible Person of the Department of Neurology</p><p>Kievskaya str. 44, Bishkek, 720000</p></bio><email xlink:type="simple">shleifer.s.g@gmail.com</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-7565-9892</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Андрианова</surname><given-names>Е. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Andrianova</surname><given-names>E. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Андрианова Елена Владимировна — кандидат медицинских наук, и. о. доцента; старший преподаватель кафедры неврологии, нейрохирургии и медицинской генетики</p><p>ул. Киевская, д. 44, г. Бишкек, 720000</p></bio><bio xml:lang="en"><p>Elena V. Andrianova — Cand. Sci. (Med.), Acting Assoc. Prof.; Senior Prof., Department of Neurology</p><p>Kievskaya str. 44, Bishkek, 720000</p></bio><email xlink:type="simple">aev.ar.81@mail.ru</email><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-8430-9504</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Жусупова</surname><given-names>А. Т.</given-names></name><name name-style="western" xml:lang="en"><surname>Jusupova</surname><given-names>A. T.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Жусупова Асель Талгатбековна — кандидат медицинских наук, и.о. доцента; старший преподаватель кафедры неврологии и клинической генетики</p><p>ул. Ахунбаева, д. 92, г. Бишкек, 720020</p></bio><bio xml:lang="en"><p>Asel T. Jusupova — Cand. Sci. (Med.), Acting Assoc. Prof.; Senior Prof., Department of Neurology and Clinical Genetics</p><p>Akhunbayeva str. 92, Bishkek, 720020</p></bio><email xlink:type="simple">astaljus@gmail.com</email><xref ref-type="aff" rid="aff-4"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Национальный госпиталь при Министерстве здравоохранения и социального развития Кыргызской Республики</institution><country>Кыргызстан</country></aff><aff xml:lang="en"><institution>National  Hospital under the Ministry of Health and Social Development of the Kyrgyz Republic</institution><country>Kyrgyzstan</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Кыргызско-Российский славянский университет имени Б.Н. Ельцина</institution><country>Кыргызстан</country></aff><aff xml:lang="en"><institution>Yeltsin Kyrgyz-Russian Slavic University</institution><country>Kyrgyzstan</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>Кыргызско-Российский Славянский университет имени Б.Н. Ельцина</institution><country>Кыргызстан</country></aff><aff xml:lang="en"><institution>Yeltsin Kyrgyz-Russian Slavic University</institution><country>Kyrgyzstan</country></aff></aff-alternatives><aff-alternatives id="aff-4"><aff xml:lang="ru"><institution>Кыргызская государственная медицинская академия им. И.К. Ахунбаева</institution><country>Кыргызстан</country></aff><aff xml:lang="en"><institution>Akhunbaev Kyrgyz State Medical Academy</institution><country>Kyrgyzstan</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2022</year></pub-date><pub-date pub-type="epub"><day>03</day><month>07</month><year>2022</year></pub-date><volume>29</volume><issue>5</issue><fpage>123</fpage><lpage>136</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Чекеева Н.Т., Шлейфер С.Г., Андрианова Е.В., Жусупова А.Т., 2022</copyright-statement><copyright-year>2022</copyright-year><copyright-holder xml:lang="ru">Чекеева Н.Т., Шлейфер С.Г., Андрианова Е.В., Жусупова А.Т.</copyright-holder><copyright-holder xml:lang="en">Chekeeva N.T., Shleifer S.G., Andrianova E.V., Jusupova A.T.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://ksma.elpub.ru/jour/article/view/2732">https://ksma.elpub.ru/jour/article/view/2732</self-uri><abstract><sec><title>Введение</title><p>Введение. Распространенность инсульта среди населения предопределена факторами риска, патогенетической гетерогенностью, генетической предрасположенностью к заболеванию. Нейроваскулярные изменения могут служить маркером тяжести состояния пациента. В исследовании методом кардиоинтервалографии изучены реакции вегетативной нервной системы у больных с ишемическим инсультом в зависимости от территории инфаркта мозга и его периода. При благоприятном исходе заболевания обнаруженные изменения регуляторных механизмов можно считать адаптивными, при летальном — дезадаптивными.</p><p>Цель исследования определение состояния вегетативной нервной системы по показателям кардиоинтервалографии у больных с инсультом в различных бассейнах кровоснабжения.</p></sec><sec><title>Методы</title><p>Методы. Обследованы 52 пациента с верифицированным диагнозом «ишемический инсульт» в острейший и острый периоды. Все пациенты разделены на 3 группы. 1-я группа — пациенты с ишемическим инсультом в бассейне средней мозговой артерии слева. 2-я группа — с ишемическим инсультом в бассейне средней мозговой артерии справа. 3-я — с ишемическим инсультом в вертебробазилярном бассейне. Отдельно описаны пациенты с летальным исходом. Функциональное состояние вегетативной нервной системы оценивали методом математического анализа вариабельности сердечного ритма по Р. М. Баевскому (1984). Кардиоинтервалографию проводили в утреннее время в 1-е сутки от начала инсульта и на 10-е сутки.</p></sec><sec><title>Результаты</title><p>Результаты. Состояние вегетативной регуляции у больных с ишемическим инсультом зависит от локализации, размера очага поражения. У больных с ишемическим инсультом в бассейне средней мозговой артерии слева и в вертебробазилярном бассейне в острейшем периоде по показателям кардиоинтервалографии преобладали парасимпатические влияния на ритм сердца, у больных с ишемическим инсультом в бассейне средней мозговой артерии справа — симпатические. В остром периоде наблюдалась общая тенденция увеличения активности противоположного отдела вегетативной нервной системы.</p></sec><sec><title>Заключение</title><p>Заключение. Достоверные изменения показателей общей мощности спектра волновых колебаний и показателя ультранизкочастотных волн в острейшем и остром периодах инсульта у обследованных больных свидетельствуют о значимости нейрогуморальных механизмов регуляции в динамике патологического состояния.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Background</title><p>Background. The high number of stroke cases is predetermined by risk factors, pathogenetic heterogeneity, genetic predisposition to the disease. Neurovascular changes can serve as a marker for the severity of the patient’s condition. By means of cardiointervalography, the reactions of the autonomic nervous system in patients with ischemic stroke were studied, depending on the territory of the cerebral infarction and its period. With a favorable outcome of the disease, the detected changes in regulatory mechanisms can be considered adaptive, while with fatal outcome — disadaptive. Objectives. Determination of the state of the autonomic nervous system by means of cardiointervalography in patients with stroke in various pools of blood supply.</p></sec><sec><title>Methods</title><p>Methods. 52 patients with a verifi ed diagnosis of ischemic stroke in the acute and peracute periods were examined. All patients were divided into 3 groups. Group 1 — patients with ischemic stroke in the middle cerebral artery territory on the left. Group 2 — with ischemic stroke in the middle cerebral artery territory on the right. Group 3 — with ischemic stroke in the vertebrobasilar territory. Patients with a fatal outcome are separately described. The functional state of the autonomic nervous system was assessed by the method of mathematical analysis of heart rate variability according to R.M. Baevsky (1984). Cardiointervalography was performed in the morning on the 1st day from the onset of the stroke and on the 10th day.</p></sec><sec><title>Results</title><p>Results. The state of autonomic regulation in patients with ischemic stroke depends on the localization and size of the lesion. According to cardiointervalography, parasympathetic effects on the rhythm of the heart prevailed in patients with ischemic stroke in the middle cerebral artery territory on the left and in the vertebrobasilar territory in the peracute period, while the sympathetic one predominated in patients with ischemic stroke in the middle cerebral artery territory on the right. In the acute period, the general tendency for the increase in activity of the opposite part of the autonomic nervous system was observed.</p></sec><sec><title>Conclusion</title><p>Conclusion. Statistically signifi cant changes in the indicators of the total power of the wave oscillation spectrum and the indicator of ultra-low-frequency waves in the peracute and acute periods of stroke in the examined patients indicate the importance of neurohumoral mechanisms of regulation in the dynamics of the pathological state</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>ишемический инсульт</kwd><kwd>вегетативная регуляция</kwd><kwd>кардиоинтервалография</kwd></kwd-group><kwd-group xml:lang="en"><kwd>ischemic stroke</kwd><kwd>autonomic regulation</kwd><kwd>cardiointervalography</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Гафаров В.В., Громова Е.А., Гагулин И.В., Панов Д.О., Гафарова А.В. Тенденция заболеваемости и смертности от сердечно-сосудистых заболеваний у населения Сибири. Клиническая медицина. 2016; 94(8): 601–608. DOI: 10.18821/0023-2149-2016-94-8-601-608</mixed-citation><mixed-citation xml:lang="en">Gafarov V.V., Gromova E.A., Gagulin I.V., Panov D.O., Gafarova A.V. Tendencies in cardiovascular morbidity and mortality in the population of Siberia. Klin. Med. 2016; 94(8): 601–608 (In Russ., English abstract). DOI: 10.18821/0023-2149-2016-94-8-601-608</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Boursin P., Paternotte S., Dercy B., Sabben C., Maïer B.. Sémantique, épidémiologie et sémiologie des accidents vasculaires cérébraux [Semantics, epidemiology and semiology of stroke]. Soins. 2018; 63(828): 24–27 (French). DOI: 10.1016/j.soin.2018.06.008</mixed-citation><mixed-citation xml:lang="en">Boursin P., Paternotte S., Dercy B., Sabben C., Maïer B.. Sémantique, épidémiologie et sémiologie des accidents vasculaires cérébraux [Semantics, epidemiology and semiology of stroke]. Soins. 2018; 63(828): 24–27 (French). DOI: 10.1016/j.soin.2018.06.008</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Wafa H.A., Wolfe C.D.A., Emmett E., Roth G.A., Johnson C.O., Wang Y. Burden of Stroke in Europe: Thirty-year projections of incidence, prevalence, deaths, and disability-adjusted life years. Stroke. 2020; 51(8): 2418–2427. DOI: 10.1161/STROKEAHA.120.029606</mixed-citation><mixed-citation xml:lang="en">Wafa H.A., Wolfe C.D.A., Emmett E., Roth G.A., Johnson C.O., Wang Y. Burden of Stroke in Europe: Thirty-year projections of incidence, prevalence, deaths, and disability-adjusted life years. Stroke. 2020; 51(8): 2418–2427. DOI: 10.1161/STROKEAHA.120.029606</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Guzik A., Bushnell C. Stroke epidemiology and risk factor management. Continuum (Minneap Minn). 2017; 23(1, Cerebrovascular Disease): 15–39. DOI: 10.1212/CON.0000000000000416</mixed-citation><mixed-citation xml:lang="en">Guzik A., Bushnell C. Stroke epidemiology and risk factor management. Continuum (Minneap Minn). 2017; 23(1, Cerebrovascular Disease): 15–39. DOI: 10.1212/CON.0000000000000416</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Гоголева А.Г., Захаров В.В. Вопросы этиологии, проявлений и терапии хронических цереброваскулярных заболеваний. Неврология, нейропсихиатрия, психосоматика. 2020; 12(5): 84–91. DOI: 10.14412/2074-2711-2020-5-84-91</mixed-citation><mixed-citation xml:lang="en">Goloveva A.G., Zakharov V.V. The etiology, manifestations, and therapy of chronic cerebrovascular diseases. Neurology, Neuropsychiatry, Psychosomatics. 2020; 12(5): 84–91 (In Russ., English abstract). DOI: 10.14412/2074-2711-2020-5-84-91</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Петров М.Г., Кучеренко С.С., Топузова М.П. Геморрагическая трансформация ишемического инсульта. Артериальная гипертензия. 2021; 27(1): 41–50. DOI: 10.18705/1607-419X-2021-27-1-41-50</mixed-citation><mixed-citation xml:lang="en">Petrov M.G., Kucherenko S.S., Topuzova M.P. Hemorrhagic transformation of ischemic stroke. Arterial Hypertension. 2021; 27(1): 41–50 (In Russ., English abstract). DOI: 10.18705/1607-419X-2021-27-1-41-50</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Цыган Н.В., Коломенцев С.В., Голохвастов С.Ю., Янишевский С.Н., Яковлева В.А., Рябцев А.В., Одинак М.М., Литвиненко И.В. Острый асимптомный инфаркт головного мозга: эпидемиология, особенности диагностики и лечения. Вестник Российской Военно-медицинской академии. 2020; S3: 99–101. DOI: 10.32863/1682-7392-2020-3-71-99-101</mixed-citation><mixed-citation xml:lang="en">Tsygan N.V., Kolomentsev S.V., Golokhvastov S.Yu., Yanishevskiy S.N., Yakovleva V.A., Ryabtsev A.V., Odinak M.M., Litvinenko I.V. Acute covert stroke: epidemiology, features of diagnosis and treatment. Bulletin of the Russian Military Medical Academy. 2020; S3: 99–101 (In Russ., English abstract). DOI: 10.32863/1682-7392-2020-3-71-99-101</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Kimura H. Stroke. Brain. Nerve. 2020; 72(4): 311–321 (Japanese). DOI: 10.11477/mf.1416201530</mixed-citation><mixed-citation xml:lang="en">Kimura H. Stroke. Brain. Nerve. 2020; 72(4): 311–321 (Japanese). DOI: 10.11477/mf.1416201530</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Bersano A., Kraemer M., Burlina A., Mancuso M., Finsterer J., Sacco S., Salvarani C., Caputi L., Chabriat H., Oberstein S.L., Federico A., Lasserve E.T., Hunt D., Dichgans M., Arnold M., Debette S., Markus H.S. Heritable and non-heritable uncommon causes of stroke. J. Neurol. 2021; 268(8): 2780–2807. DOI: 10.1007/s00415-020-09836-x</mixed-citation><mixed-citation xml:lang="en">Bersano A., Kraemer M., Burlina A., Mancuso M., Finsterer J., Sacco S., Salvarani C., Caputi L., Chabriat H., Oberstein S.L., Federico A., Lasserve E.T., Hunt D., Dichgans M., Arnold M., Debette S., Markus H.S. Heritable and non-heritable uncommon causes of stroke. J. Neurol. 2021; 268(8): 2780–2807. DOI: 10.1007/s00415-020-09836-x</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Черных Е.Р., Шевела Е.Я., Морозов С.А., Останин А.А. Иммунопатогенетические аспекты ишемического инсульта. Медицинская иммунология. 2018; 20(1): 19–34. DOI: 10.15789/1563-0625-2018-1-19-34</mixed-citation><mixed-citation xml:lang="en">Chernykh E.R., Shevela E.Y., Morozov S.A., Ostanin A.A. Immunopathogenetic aspects of ischemic stroke. Medical Immunology. 2018; 20(1): 19–34 (In Russ., English abstract). DOI: 10.15789/1563-0625-2018-1-19-34</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Bluher A., Devan W.J., Holliday E.G., Nalls M., Parolo S., Bione S., Giese A.K., Boncoraglio G.B., Maguire J.M., Müller-Nurasyid M., Gieger C., Meschia J.F., Rosand J., Rolfs A., Kittner S.J., Mitchell B.D., O’Connell J.R., Cheng Y.C. Heritability of young- and old-onset ischaemic stroke. Eur. J. Neurol. 2015; 22(11): 1488–1491. DOI: 10.1111/ene.12827</mixed-citation><mixed-citation xml:lang="en">Bluher A., Devan W.J., Holliday E.G., Nalls M., Parolo S., Bione S., Giese A.K., Boncoraglio G.B., Maguire J.M., Müller-Nurasyid M., Gieger C., Meschia J.F., Rosand J., Rolfs A., Kittner S.J., Mitchell B.D., O’Connell J.R., Cheng Y.C. Heritability of young- and old-onset ischaemic stroke. Eur. J. Neurol. 2015; 22(11): 1488–1491. DOI: 10.1111/ene.12827</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Powers W.J., Rabinstein A.A., Ackerson T., Adeoye O.M., Bambakidis N.C., Becker K., Biller J., Brown M., Demaerschalk B.M., Hoh B., Jauch E.C., Kidwell C.S., Leslie-Mazwi T.M., Ovbiagele B., Scott P.A., Sheth K.N., Southerland A.M., Summers D.V., Tirschwell D.L.; American Heart Association Stroke Council. 2018 Guidelines for the Early Management of Patients With Acute Ischemic Stroke: A Guideline for Healthcare Professionals From the American Heart Association/American Stroke Association. Stroke. 2018; 49(3): e46–e110. DOI: 10.1161/STR.0000000000000158</mixed-citation><mixed-citation xml:lang="en">Powers W.J., Rabinstein A.A., Ackerson T., Adeoye O.M., Bambakidis N.C., Becker K., Biller J., Brown M., Demaerschalk B.M., Hoh B., Jauch E.C., Kidwell C.S., Leslie-Mazwi T.M., Ovbiagele B., Scott P.A., Sheth K.N., Southerland A.M., Summers D.V., Tirschwell D.L.; American Heart Association Stroke Council. 2018 Guidelines for the Early Management of Patients With Acute Ischemic Stroke: A Guideline for Healthcare Professionals From the American Heart Association/American Stroke Association. Stroke. 2018; 49(3): e46–e110. DOI: 10.1161/STR.0000000000000158</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Shi Y., Guo L., Chen Y., Xie Q., Yan Z., Liu Y., Kang J., Li S. Risk factors for ischemic stroke: differences between cerebral small vessel and large artery atherosclerosis aetiologies. Folia. Neuropathol. 2021; 59(4): 378–385. DOI: 10.5114/fn.2021.112007</mixed-citation><mixed-citation xml:lang="en">Shi Y., Guo L., Chen Y., Xie Q., Yan Z., Liu Y., Kang J., Li S. Risk factors for ischemic stroke: differences between cerebral small vessel and large artery atherosclerosis aetiologies. Folia. Neuropathol. 2021; 59(4): 378–385. DOI: 10.5114/fn.2021.112007</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Прекина В.И., Самолькина О.Г. Анализ вариабельности ритма сердца при ишемическом инсульте в зависимости от тяжести и локализации очага. Архивъ внутренней медицины. 2014; 5: 42–46. DOI: 10.20514/2226-6704-2014-0-5-42-46</mixed-citation><mixed-citation xml:lang="en">Prekina V.I., Samolkina O.G. Analysis of heart rhythm variability in ischemic stroke depending on the severity and localization of the focus. The Russian Archives of Internal Medicine. 2014; 5: 42–46 (In Russ., English abstract). DOI: 10.20514/2226-6704-2014-0-5-42-46</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Dhar R., Hamzehloo A., Kumar A., Chen Y., He J., Heitsch L., Slowik A., Strbian D., Lee J.M. Hemispheric CSF volume ratio quantifies progression and severity of cerebral edema after acute hemispheric stroke. J. Cereb. Blood. Flow. Metab. 2021; 41(11): 2907–2915. DOI: 10.1177/0271678X211018210</mixed-citation><mixed-citation xml:lang="en">Dhar R., Hamzehloo A., Kumar A., Chen Y., He J., Heitsch L., Slowik A., Strbian D., Lee J.M. Hemispheric CSF volume ratio quantifies progression and severity of cerebral edema after acute hemispheric stroke. J. Cereb. Blood. Flow. Metab. 2021; 41(11): 2907–2915. DOI: 10.1177/0271678X211018210</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Saccomano S.J. Ischemic stroke: the first 24 hours. Nurse Pract. 2012; 37(10): 12–18; quiz 18–19. DOI: 10.1097/01.NPR.0000419296.95063.8f</mixed-citation><mixed-citation xml:lang="en">Saccomano S.J. Ischemic stroke: the first 24 hours. Nurse Pract. 2012; 37(10): 12–18; quiz 18–19. DOI: 10.1097/01.NPR.0000419296.95063.8f</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Kozyolkin O., Kuznietsov A., Novikova L. Prediction of the lethal outcome of acute recurrent cerebral ischemic hemispheric stroke. Medicina (Kaunas). 2019; 55(6): 311. DOI: 10.3390/medicina55060311</mixed-citation><mixed-citation xml:lang="en">Kozyolkin O., Kuznietsov A., Novikova L. Prediction of the lethal outcome of acute recurrent cerebral ischemic hemispheric stroke. Medicina (Kaunas). 2019; 55(6): 311. DOI: 10.3390/medicina55060311</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Wijdicks E.F., Diringer M.N. Middle cerebral artery territory infarction and early brain swelling: progression and effect of age on outcome. Mayo. Clin. Proc. 1998; 73(9): 829–836. DOI: 10.4065/73.9.829</mixed-citation><mixed-citation xml:lang="en">Wijdicks E.F., Diringer M.N. Middle cerebral artery territory infarction and early brain swelling: progression and effect of age on outcome. Mayo. Clin. Proc. 1998; 73(9): 829–836. DOI: 10.4065/73.9.829</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Qureshi A.I., Suarez J.I., Yahia A.M., Mohammad Y., Uzun G., Suri M.F., Zaidat O.O., Ayata C., Ali Z., Wityk R.J. Timing of neurologic deterioration in massive middle cerebral artery infarction: a multicenter review. Crit. Care. Med. 2003; 31(1): 272–277. DOI: 10.1097/00003246-200301000-00043</mixed-citation><mixed-citation xml:lang="en">Qureshi A.I., Suarez J.I., Yahia A.M., Mohammad Y., Uzun G., Suri M.F., Zaidat O.O., Ayata C., Ali Z., Wityk R.J. Timing of neurologic deterioration in massive middle cerebral artery infarction: a multicenter review. Crit. Care. Med. 2003; 31(1): 272–277. DOI: 10.1097/00003246-200301000-00043</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Qin C., Zhou L.Q., Ma X.T., Hu Z.W., Yang S., Chen M., Bosco D.B., Wu L.J., Tian D.S. Dual Functions of Microglia in Ischemic Stroke. Neurosci. Bull. 2019; 35(5): 921–933. DOI: 10.1007/s12264-019-00388-3</mixed-citation><mixed-citation xml:lang="en">Qin C., Zhou L.Q., Ma X.T., Hu Z.W., Yang S., Chen M., Bosco D.B., Wu L.J., Tian D.S. Dual Functions of Microglia in Ischemic Stroke. Neurosci. Bull. 2019; 35(5): 921–933. DOI: 10.1007/s12264-019-00388-3</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Петрова О.В., Скворцов В.В. Ишемический инсульт в клинической практике. Врач. 2020; 31(12): 16–19. DOI: 10.29296/25877305-2020-12-03</mixed-citation><mixed-citation xml:lang="en">Petrova O, Skvortsov V. Ischemic stroke in clinical practice. Vrach. 2020; 31(12): 16–19. DOI: 10.29296/25877305-2020-12-03</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Гусев Е.И., Чуканова А.С. Современные патогенетические аспекты формирования хронической ишемии мозга. Журнал неврологии и психиатрии им. C.C. Корсакова. 2015; 115(3): 4–8. DOI: 10.17116/jnevro2015115314-8</mixed-citation><mixed-citation xml:lang="en">Gusev E.I., Chukanova A.S. Modern pathogenetic aspects of development of cerebral chronic ischemia. Zhurnal Nevrologii i Psikhiatrii im. S.S. Korsakova. 2015; 115(3): 4–8 (In Russ., English abstract). DOI: 10.17116/jnevro2015115314-8</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Koga S., Roemer S.F., Tipton P.W., Low P.A., Josephs K.A., Dickson D.W. Cerebrovascular pathology and misdiagnosis of multiple system atrophy: An autopsy study. Parkinsonism Relat. Disord. 2020; 75: 34–40. DOI: 10.1016/j.parkreldis.2020.05.018</mixed-citation><mixed-citation xml:lang="en">Koga S., Roemer S.F., Tipton P.W., Low P.A., Josephs K.A., Dickson D.W. Cerebrovascular pathology and misdiagnosis of multiple system atrophy: An autopsy study. Parkinsonism Relat. Disord. 2020; 75: 34–40. DOI: 10.1016/j.parkreldis.2020.05.018</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Ferrer I., Vidal N. Neuropathology of cerebrovascular diseases. Handb. Clin. Neurol. 2017; 145: 79–114. DOI: 10.1016/B978-0-12-802395-2.00007-9</mixed-citation><mixed-citation xml:lang="en">Ferrer I., Vidal N. Neuropathology of cerebrovascular diseases. Handb. Clin. Neurol. 2017; 145: 79–114. DOI: 10.1016/B978-0-12-802395-2.00007-9</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Чуканова А.С., Чуканова Е.И., Надарейшвили Г.Г., Гулиева М.Ш., Гусев Е.И. Патогенетические аспекты формирования острой фокальной ишемии головного мозга. Журнал неврологии и психиатрии им. C.C. Корсакова. 2017; 117(12-2): 4–10. DOI: 10.17116/jnevro20171171224-10</mixed-citation><mixed-citation xml:lang="en">Chukanova A.S., Chukanova E.I., Nadareishvili G.G., Gulieva M.S., Gusev E.I. Pathogenetic aspects of the development of acute focal cerebral ischemia. Zh. Nevrol. Psikhiatr. im S.S. Korsakova. 2017; 117(12. Vyp. 2): 4–10 (In Russ., English abstract). DOI: 10.17116/jnevro20171171224-10</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Прекина В.И., Чернова И.Ю., Ефремова О.Н. Вариабельность ритма сердца в подостром периоде ишемического инсульта. Российский кардиологический журнал. 2019; 24(S2): 8. DOI: 10.15829/1560-4071-2019-s2</mixed-citation><mixed-citation xml:lang="en">Prekina V.I., Chernova I.Yu., Efremova O.N. Heart rate variability in the subacute period of ischemic stroke. Russian Journal of Cardiology. 2019; 24(S2): 8 (In Russ.). DOI: 10.15829/1560-4071-2019-s2</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Голубев А.М. Модели ишемического инсульта (обзор). Общая реаниматология. 2020; 16(1): 59–72. DOI: 10.15360/1813-9779-2020-1-59-72</mixed-citation><mixed-citation xml:lang="en">Golubev A.M. Models of Ischemic Stroke (Review). General Reanimatology. 2020; 16(1): 59–72 (In Russ., English abstract). DOI: 10.15360/1813-9779-2020-1-59-72</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Рахматуллин А.Р., Бахтиярова К.З., Магжанов Р.В. Кардиоинтервалография у больных рассеянным склерозом. Неврология, нейропсихиатрия, психосоматика. 2016; 8(3): 39–42. DOI: 10.14412/2074-2711-2016-3-39-42</mixed-citation><mixed-citation xml:lang="en">Rakhmatullin A.R., Bakhtiyarova K.Z., Magzhanov R.V. Cardiointervalography in patients with multiple sclerosis. Neurology, Neuropsychiatry, Psychosomatics. 2016; 8(3): 39–42 (In Russ., English abstract). DOI: 10.14412/2074-2711-2016-3-39-42</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Повереннова И.Е., Захаров А.В., Васемазова Е.Н., Хивинцева Е.В., Новикова Н.П. Оценка вариабельности ритма сердца в диагностике вегетативной дисфункции при хронической ишемии головного мозга. Наука и инновации в медицине. 2019; 4(4): 25–28. DOI: 10.35693/2500-1388-2019-4-4-25-28</mixed-citation><mixed-citation xml:lang="en">Poverennova I.E., Zakharov A.V., Vasemazova E.N., Khivintseva E.V., Novikova N.P. Evaluation of heart rhythm variability in diagnosis of vegetative dysfunction in chronic cerebral ischemia. Science and Innovations in Medicine. 2019; 4(4): 25–28 (In Russ., English abstract). DOI: 10.35693/2500-1388-2019-4-4-25-28</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Батыров М.А., Мурзалиев М.А. Кардиоинтервалография в корреляции с клинико-нейровизуальными данными у пациентов с геморрагическим инсультом мозжечка. Наука, новые технологии и инновации Кыргызстана. 2020; 8: 59–63. DOI: 10.26104/NNTIK.2019.45.557</mixed-citation><mixed-citation xml:lang="en">Batyrov M.A., Murzaliev A.M. Cardiointervalography in correlation with clinical and neurovisual data in patients with hemorragic stroke science and innovative technologies. Nauka, Novye Tekhnologii i Innovatsii Kyrgyzstana. 2020; 8: 59–63 (In Russ., English abstract). DOI: 10.26104/NNTIK.2019.45.557</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Powers W.J., Rabinstein A.A., Ackerson T., Adeoye O.M., Bambakidis N.C., Becker K., Biller J., Brown M., Demaerschalk B.M., Hoh B., Jauch E.C., Kidwell C.S., Leslie-Mazwi T.M., Ovbiagele B., Scott P.A., Sheth K.N., Southerland A.M., Summers D.V., Tirschwell D.L. Guidelines for the Early Management of Patients With Acute Ischemic Stroke: 2019 Update to the 2018 Guidelines for the Early Management of Acute Ischemic Stroke: A Guideline for Healthcare Professionals From the American Heart Association/American Stroke Association. Stroke. 2019; 50(12): e344–e418. DOI: 10.1161/STR.0000000000000211</mixed-citation><mixed-citation xml:lang="en">Powers W.J., Rabinstein A.A., Ackerson T., Adeoye O.M., Bambakidis N.C., Becker K., Biller J., Brown M., Demaerschalk B.M., Hoh B., Jauch E.C., Kidwell C.S., Leslie-Mazwi T.M., Ovbiagele B., Scott P.A., Sheth K.N., Southerland A.M., Summers D.V., Tirschwell D.L. Guidelines for the Early Management of Patients With Acute Ischemic Stroke: 2019 Update to the 2018 Guidelines for the Early Management of Acute Ischemic Stroke: A Guideline for Healthcare Professionals From the American Heart Association/American Stroke Association. Stroke. 2019; 50(12): e344–e418. DOI: 10.1161/STR.0000000000000211</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
