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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">ksma</journal-id><journal-title-group><journal-title xml:lang="ru">Кубанский научный медицинский вестник</journal-title><trans-title-group xml:lang="en"><trans-title>Kuban Scientific Medical Bulletin</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1608-6228</issn><issn pub-type="epub">2541-9544</issn><publisher><publisher-name>Kuban State Medical University</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.25207/1608-6228-2022-29-2-14-27</article-id><article-id custom-type="elpub" pub-id-type="custom">ksma-2739</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ СТАТЬИ. КЛИНИЧЕСКАЯ МЕДИЦИНА</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL ARTICLES. CLINICAL MEDICINE</subject></subj-group></article-categories><title-group><article-title>Сравнение ремоделирования предсердий после процедур «лабиринт-3» и «криолабиринт» при сочетанных вмешательствах на сердце: ретроспективное исследование</article-title><trans-title-group xml:lang="en"><trans-title>Atrial remodelling comparison after maze-3 and cryo-maze procedures in combined cardiac interventions: a retrospective study</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-7704-2669</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Антипов</surname><given-names>Г. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Antipov</surname><given-names>G. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Антипов Георгий Николаевич — кандидат медицинских наук, заведующий кардиохирургическим отделением № 2 </p><p>тел. +7(981) 461-69-17</p><p>Калининградское шоссе, д. 4, п. Родники, Калининградская область, 238312</p></bio><bio xml:lang="en"><p>Georgy N. Antipov — Cand. Sci. (Med.), Head of Department of Cardiac Surgery No. 2</p><p>tel. +7(981) 461-69-17 </p><p>Kaliningradskoe Shosse, 4, Rodniki stlmt., 238312</p></bio><email xlink:type="simple">enzo17@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-0983-3773</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Постол</surname><given-names>А. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Postol</surname><given-names>A. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Постол Анжелика Сергеевна — кандидат медицинских наук, врач отделения хирургического лечения сложных нарушений ритма сердца и электро-кардиостимуляции</p><p>Калининградское шоссе, д. 4, п. Родники, Калининградская область, 238312</p></bio><bio xml:lang="en"><p>Anzhelika S. Postol — Cand. Sci. (Med.), Physician, Department of Complex Heart Rhythm Disturbance and Pacing Surgery </p><p>Kaliningradskoe Shosse, 4, Rodniki stlmt., 238312</p></bio><email xlink:type="simple">postol-75@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-4027-4159</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Котов</surname><given-names>С. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Kotov</surname><given-names>S. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Котов Сергей Николаевич — заведующий отделением функциональной диагностики</p><p>Калининградское шоссе, д. 4, п. Родники, Калининградская область, 238312</p></bio><bio xml:lang="en"><p>Sergey N. Kotov — Head of the Department of Functional Diagnostics </p><p>Kaliningradskoe Shosse, 4, Rodniki stlmt., 238312</p></bio><email xlink:type="simple">ksn82@rambler.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-9007-5273</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Макарова</surname><given-names>М. О.</given-names></name><name name-style="western" xml:lang="en"><surname>Makarova</surname><given-names>M. O.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Макарова Марина Осеевна — кандидат медицинских наук, доцент; доцент кафедры терапии</p><p>ул. А. Невского, д. 14, г. Калининград, 236041</p></bio><bio xml:lang="en"><p>Marina O. Makarova — Cand. Sci. (Med.), Assoc. Prof., Chair of Therapy </p><p>Nevskogo str., 14, Kaliningrad, 236041</p></bio><email xlink:type="simple">marinacardio@rambler.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-5572-3076</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Шнейдер</surname><given-names>Ю. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Shneider</surname><given-names>Yu. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Шнейдер Юрий Александрович — доктор медицинских наук, профессор; главный врач</p><p>Калининградское шоссе, д. 4, п. Родники, Калининградская область, 238312</p></bio><bio xml:lang="en"><p>Yuriy A. Shneider — Dr. Sci. (Med.), Prof., Chief Physician</p><p>Kaliningradskoe Shosse, 4, Rodniki stlmt., 238312</p></bio><email xlink:type="simple">schneider@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Федеральное государственное бюджетное учреждение «Федеральный центр высоких медицинских технологий» Министерства здравоохранения Российской Федерации</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Federal Centre for High Medicine Technologies</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Федеральное государственное автономное образовательное учреждение высшего образования «Балтийский федеральный университет имени Иммануила Канта»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Immanuel Kant Baltic Federal University</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2022</year></pub-date><pub-date pub-type="epub"><day>27</day><month>03</month><year>2022</year></pub-date><volume>29</volume><issue>2</issue><fpage>14</fpage><lpage>27</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Антипов Г.Н., Постол А.С., Котов С.Н., Макарова М.О., Шнейдер Ю.А., 2022</copyright-statement><copyright-year>2022</copyright-year><copyright-holder xml:lang="ru">Антипов Г.Н., Постол А.С., Котов С.Н., Макарова М.О., Шнейдер Ю.А.</copyright-holder><copyright-holder xml:lang="en">Antipov G.N., Postol A.S., Kotov S.N., Makarova M.O., Shneider Y.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://ksma.elpub.ru/jour/article/view/2739">https://ksma.elpub.ru/jour/article/view/2739</self-uri><abstract><p>Введение. Процедура «лабиринт» направлена на устранение фибрилляции предсердий (ФП), восстановление синусового ритма (СР) и восстановление сократительной функции предсердий. При этом имеются противоречивые данные относительно степени ремоделирования предсердий в зависимости от использованной методики. Исходя из этого определилась цель нашего исследования.Цель исследования — сравнение ремоделирования предсердий после операции «лабиринт-3» (“cut-and-sew”) и ее варианта — двухпредсердного криолабиринта с помощью двухмерной эхокардиографии.Методы. Дизайн исследования — ретроспективное неконтролируемое исследование с прерванным временным рядом двух групп пациентов, отобранных с помощью метода псевдорандомизации в зависимости от варианта хирургического лечения ФП с удерживаемым регулярным ритмом сердца. В период с 2012 по 2021 год выполнено 217 сочетанных вмешательств на сердце по методике «лабиринт-3» и 113 по методике «криолабиринт». Сочетанные вмешательства включали клапанную коррекцию, шунтирование коронарных артерий и их комбинацию. Ввиду различий по срокам отдаленного наблюдения группы подверглись псевдорандомизации с отбором по 50 пациентов с восстановленным и удерживаемым синусовым ритмом в каждой по принципу «ближайший сосед» с использованием метода логистической регрессии. Средний период наблюдения составил 6 (1–17) месяцев. Пациенты имели пароксизмальную, персистирующую и длительно персистирующую формы ФП. Далее был выполнен анализ эхокардиографических показателей до и после операции в отдаленные сроки наблюдения с целью определения динамики ремоделирования предсердий.Результаты. В отдаленные сроки наблюдения происходит статистически значимое уменьшение объемов предсердий при внутригрупповом сравнении. При этом при межгрупповом сравнении статистически более выраженное ремоделирование происходит после процедуры «лабиринт-3». Полученные значения группы 1 против группы 2: средний объем левого предсердия 120 и 125 мл3 (р = 0,011), размер левого предсердия в апикальной позиции 52 и 53 мм (р = 0,023), размер правого предсердия в апикальной позиции 58 и 62 мм (р = 0,004), размер правого предсердия в парастернальной позиции по короткой оси 43 и 45 мм (р = 0,004), площадь правого предсердия из апикальной 4-камерной позиции 25 и 28 см2 (р = 0,007). Пациенты с удерживанием регулярного предсердного ритма, по данным долговременных наблюдений, имели позитивные показатели восстановления систолической функции предсердий (отношение Е/А увеличивалось в среднем до 1,5) в обеих группах сравнения.Заключение. После исследованных нами вариантов операций «лабиринт» процессы ремоделирования происходят в обоих предсердиях. Более выраженное уменьшение объемов предсердий происходит после процедуры «лабиринт-3». Наличие синусового ритма характеризуется физиологическим проведением по проводящей системе сердца, что приводит к механическому и электрическому ремоделированию предсердий.</p></abstract><trans-abstract xml:lang="en"><p>Background. The maze procedure aims to eliminate atrial fibrillation (AF), restore sinus rhythm (SR) and atrial contractility. However, conflicting evidence exists regarding the extent of atrial remodelling in various techniques, which directed the focus of our study.Objectives. An atrial remodelling comparison after a cut-and-sew maze-3 surgery and its biatrial cryo-maze modification using 2D echocardiography.Methods. The study is a retrospective uncontrolled interrupted two-cohort time-series trial, with patients selected by pseudorandomisation according to a normal sinus rhythm-maintaining AF surgery method. A total of 217 maze-3 and 113 cryo-maze combined cardiac interventions have been performed within 2012–2021. The interventions included valve repair, coronary artery bypass grafting and their combination. Due to differences in long-term follow-up, the cohorts were pseudorandomised to select by 50 restored vs. maintained sinus rhythm patients using a nearest-neighbour classifier coupled with logistic regression. Mean follow-up period was 6 (1–17) months. The patients had paroxysmal, persistent and longstanding persistent AF. Echocardiography values prior to and long-term post-surgery were further analysed to determine the atrial remodelling dynamics. Results. A statistically significant atrial volume reduction is evident in a long-term within-cohort comparison. Meanwhile, a statistically more pronounced remodelling is observed between cohorts after maze-3 procedure. The cohort 1 vs. 2 estimates are: mean left atrial volume 120/125 mL3 (p = 0.011), left atrial size in apical view 52/53 mm (p = 0.023), right atrial size in apical view 58/62 mm (p = 0.004), right atrial size in parasternal short axis view 43/45 mm (p = 0.004), right atrial area in apical 4-chamber view 25/28 cm2 (p = 0.007). Maintained atrial pacing patients had positive systolic atrial function recovery rates (E/A ratio increased to average 1.5) in the long-term in both comparison cohorts.Conclusion. Remodelling is biatrial after all the maze procedures compared. A more pronounced atrial volume reduction occurs after maze-3 surgery. The presence of sinus rhythm is facilitated by cardiac conduction leading to mechanical and electrical remodelling of the atria.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>фибрилляция предсердий</kwd><kwd>операция лабиринт</kwd><kwd>ремоделирование&#13;
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