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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">ksma</journal-id><journal-title-group><journal-title xml:lang="ru">Кубанский научный медицинский вестник</journal-title><trans-title-group xml:lang="en"><trans-title>Kuban Scientific Medical Bulletin</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1608-6228</issn><issn pub-type="epub">2541-9544</issn><publisher><publisher-name>Kuban State Medical University</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.25207/1608-6228-2023-30-6-81-88</article-id><article-id custom-type="elpub" pub-id-type="custom">ksma-3146</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>КЛИНИЧЕСКИЕ СЛУЧАИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>CLINICAL CASE</subject></subj-group></article-categories><title-group><article-title>Карциноидный папилломатоз кожи Готтрона: клинический случай</article-title><trans-title-group xml:lang="en"><trans-title>Gottron’s Carcinoid Papillomatosis: Case Report</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-5552-8764</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Балабанович</surname><given-names>Т. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Balabanovich</surname><given-names>T. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Балабанович Татьяна Игоревна — кандидат медицинских наук, доцент 1-й кафедры внутренних болезней учреждения образования «Гродненский государственный медицинский университет».</p><p>Ул. М. Горького, д. 80, Гродно, 230009</p></bio><bio xml:lang="en"><p>Tatsiana I. Balabanovich — Cand. Sci. (Med.), Assoc. Prof. of the 1st Department of Internal Diseases.</p><p>Gorkogo str., 80, Grodno, 230009</p></bio><email xlink:type="simple">TatiBo1@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-8902-8533</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Сурмач</surname><given-names>Е. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Surmach</surname><given-names>K. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Сурмач Екатерина Михайловна — кандидат медицинских наук, доцент, доцент кафедры пропедевтики внутренних болезней учреждения образования «Гродненский государственный медицинский университет».</p><p>Ул. М. Горького, д. 80, Гродно, 230009</p></bio><bio xml:lang="en"><p>Katsiaryna M. Surmach — Cand. Sci. (Med.), Assoc. Prof., Associate Professor of the Department of Propaedeutics of Internal Diseases.</p><p>Gorkogo str., 80, Grodno, 230009</p></bio><email xlink:type="simple">esurmach@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-9841-9015</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Демидик</surname><given-names>С. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Dziamidzik</surname><given-names>S. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Демидик Светлана Николаевна — кандидат медицинских наук, доцент; доцент кафедры фтизиопульмонологии.</p><p>Ул. М. Горького, д. 80, Гродно, 230009</p></bio><bio xml:lang="en"><p>Sviatlana N. Dziamidzik — Cand. Sci. (Med.), Assoc. Prof., Associate Professor of the Department of Phthisiopulmonology.</p><p>Gorkogo str., 80, Grodno, 230009</p></bio><email xlink:type="simple">svdemidik@tut.by</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0001-8500-5470</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Будревич</surname><given-names>О. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Budrevich</surname><given-names>V. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Будревич Ольга Викторовна — врач-терапевт приемного отделения.</p><p>Ул. Мицкевича, д. 1, г. Лида, 231300</p></bio><bio xml:lang="en"><p>Volha V. Budrevich — physician in the emergency department of the health care institution “Lida Central Regional Hospital”.</p><p>Mitskevicha str., 1, Lida, 231300</p></bio><email xlink:type="simple">23olga03olga99@mail.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0009-4063-6410</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Варнакуласурия Фернандо</surname><given-names>Р. Ш.</given-names></name><name name-style="western" xml:lang="en"><surname>Warnakulasuriya Fernando</surname><given-names>R. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Варнакуласурия Фернандо Рашина Шанани — студентка.</p><p>Ул. М. Горького, д. 80, Гродно, 230009</p><p> </p></bio><bio xml:lang="en"><p>Warnakulasuriya Fernando Rashina Shanani — student.</p><p>Gorkogo str., 80, Grodno, 230009</p></bio><email xlink:type="simple">shananifdo99@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Учреждение образования «Гродненский государственный медицинский университет»</institution><country>Беларусь</country></aff><aff xml:lang="en"><institution>Grodno State Medical University</institution><country>Belarus</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Учреждение здравоохранения «Лидская центральная районная больница»</institution><country>Беларусь</country></aff><aff xml:lang="en"><institution>Lida Central District Hospital</institution><country>Belarus</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2023</year></pub-date><pub-date pub-type="epub"><day>22</day><month>12</month><year>2023</year></pub-date><volume>30</volume><issue>6</issue><fpage>81</fpage><lpage>88</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Балабанович Т.И., Сурмач Е.М., Демидик С.Н., Будревич О.В., Варнакуласурия Фернандо Р.Ш., 2023</copyright-statement><copyright-year>2023</copyright-year><copyright-holder xml:lang="ru">Балабанович Т.И., Сурмач Е.М., Демидик С.Н., Будревич О.В., Варнакуласурия Фернандо Р.Ш.</copyright-holder><copyright-holder xml:lang="en">Balabanovich T.I., Surmach K.M., Dziamidzik S.N., Budrevich V.V., Warnakulasuriya Fernando R.S.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://ksma.elpub.ru/jour/article/view/3146">https://ksma.elpub.ru/jour/article/view/3146</self-uri><abstract><sec><title>Введение</title><p>Введение. Папилломатоз Готтрона — редкий доброкачественный дерматоз с псевдоэпителиоматозной гиперплазией эпидермиса, впервые описанный немецким дерматологом H. A. Gottron как самостоятельное заболевание. Инвазивный эпидермальный рост и гиперкератоз не имеют признаков малигнизации. Хроническая венозная недостаточность и лимфедема могут быть ассоциированы с различными вторичными поражениями кожи: формированием язв, гиперкератоза и папилломатоза кожи, а также инфекционными осложнениями. Папилломатоз кожи может быть проявлением паранеопластического синдрома, что требует проведения тщательного дифференциального диагноза. Своевременная терапия осложнений у пациента с сопутствующей соматической патологией с участием многопрофильной команды специалистов необходима с целью улучшения прогноза. Учитывая относительную редкость папилломатоза Готтрона и недостаточную осведомленность практикующих врачей в вопросах его дифференциальной диагностики, представляем настоящий клинический разбор.</p><p>Описание клинического случая. Пациент Л., 42 года (индекс массы тела — 76,5 кг/м2), с хронической лимфовенозной недостаточностью, лимфедемой, рожистым воспалением правой нижней конечности, ассоциированными с неуточненным папилломатозом кожи, был госпитализирован в экстренном порядке в учреждение здравоохранения «Городская клиническая больница № 3» г. Гродно (Республика Беларусь), консультирован мультидисциплинарной командой клиницистов: терапевтом, кардиологом, дерматологом, эндокринологом, инфекционистом, хирургом. С учетом клинического статуса пациента и по ретроспективному анализу архивных записей о ранее выполненных пациенту обследованиях в условиях учреждения здравоохранения «Гродненская университетская клиника» установлен тип дерматоза — папилломатоз Готтрона обеих нижних конечностей. С учетом клинического диагноза пациента была инициирована комплексная терапия в условиях стационара, которая затем была продолжена на амбулаторном этапе.</p></sec><sec><title>Заключение</title><p>Заключение. Адекватное долгосрочное лечение морбидного ожирения, хронической лимфовенозной недостаточности необходимо для профилактики серьезных осложнений. Согласно литературным данным, своевременная диагностика редкого дерматоза — папилломатоза Готтрона, назначение адекватной терапии определяют возможность регресса на ранних стадиях развития заболевания.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Introduction</title><p>Introduction. Gottron’s papillomatosis is a rare benign type of dermatosis with pseudoepitheliomatous hyperplasia of the epidermis, first described as an independent disease by the German dermatologist H.A. Gottron. Invasive epidermal growth and hyperkeratosis reveal no signs of malignancy. Chronic venous insufficiency and lymphedema can be associated with various secondary skin lesions: the formation of ulcers, hyperkeratosis and skin papillomatosis, as well as infectious complications. Skin papillomatosis may be a manifestation of paraneoplastic syndrome, which requires a careful differential diagnosis. Timely treatment of complications in a patient with concomitant somatic pathology performed by a multidisciplinary team of specialists is necessary to improve the prognosis. Considering the relative rarity of Gottron’s papillomatosis and the lack of awareness among practicing physicians regarding the differential diagnosis of this disease, we present this clinical analysis.</p><p>Description of a clinical case. Patient L., 42 years old (body mass index — 76.5 kg/m2) with chronic lymphovenous insufficiency, lymphedema, erysipelas of the right lower limb associated with unspecified skin papillomatosis, was urgently hospitalized in a health care institution “City Clinical Hospital No. 3” of Grodno (Republic of Belarus), consulted by a multidisciplinary team of clinicians including a therapist, a cardiologist, a dermatologist, an endocrinologist, an infectious disease specialist, and a surgeon. Taking into account the clinical status of the patient and the retrospective analysis of archival records of previous examinations performed on the patient in the health care institution “Grodno University Clinic”, the type of dermatosis was determined as Gottron’s papillomatosis of both lower extremities. In terms of the clinical diagnosis of the patient, complex therapy was initiated in a hospital setting, which was then continued at the outpatient stage.</p></sec><sec><title>Conclusion</title><p>Conclusion. Adequate long-term treatment of morbid obesity and chronic lymphovenous insufficiency is necessary to prevent serious complications. According to the academic literature, timely diagnosis of such a rare dermatosis as Gottron’s papillomatosis, as well as the prescription of adequate therapy determine the possibility of regression in the early stages of the disease.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>карциноидный папилломатоз кожи Готтрона</kwd><kwd>морбидное ожирение</kwd><kwd>хроническая венозная недостаточность</kwd><kwd>лимфедема</kwd><kwd>рожа</kwd></kwd-group><kwd-group xml:lang="en"><kwd>Gottron’s cutaneous carcinoid papillomatosis</kwd><kwd>morbid obesity</kwd><kwd>chronic venous insufficiency</kwd><kwd>lymphedema</kwd><kwd>erysipelas</kwd></kwd-group><funding-group><funding-statement xml:lang="ru">авторы заявляют об отсутствии спонсорской поддержки при проведении исследования</funding-statement><funding-statement xml:lang="en">The authors declare no sponsorship support for the study</funding-statement></funding-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Тлиш М.М., Кузнецова Т.Г., Сычева Н.Л. 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