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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">ksma</journal-id><journal-title-group><journal-title xml:lang="ru">Кубанский научный медицинский вестник</journal-title><trans-title-group xml:lang="en"><trans-title>Kuban Scientific Medical Bulletin</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1608-6228</issn><issn pub-type="epub">2541-9544</issn><publisher><publisher-name>Kuban State Medical University</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.25207/1608-6228-2024-31-3-44-56</article-id><article-id custom-type="elpub" pub-id-type="custom">ksma-3468</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ СТАТЬИ. КЛИНИЧЕСКАЯ МЕДИЦИНА</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL ARTICLES. CLINICAL MEDICINE</subject></subj-group></article-categories><title-group><article-title>Повышение внутрипросветного давления в тонкой кишке как важный фактор развития внутрибрюшной гипертензии у больных с вторичным распространенным перитонитом: наблюдательное проспективное исследование</article-title><trans-title-group xml:lang="en"><trans-title>Increased intraluminal pressure in the small intestine as an important factor in the development of intra-abdominal hypertension in patients with diffuse secondary peritonitis: An observational prospective study</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-8668-7442</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Попандопуло</surname><given-names>К. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Popandopulo</surname><given-names>K. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Попандопуло Константин Иванович — доктор медицинских наук, доцент; заведующий кафедрой факультетской и госпитальной хирургии</p><p>ул. им. Митрофана Седина, д. 4, г. Краснодар, 350063</p></bio><bio xml:lang="en"><p>Konstantin I. Popandopulo — Dr. Sci. (Med.), Assoc. Prof., Head of Department of Faculty and Hospital Surgery</p><p>Mitrofana Sedina str., 4, Krasnodar, 350063</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-7986-4455</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Коровин</surname><given-names>А. Я.</given-names></name><name name-style="western" xml:lang="en"><surname>Korovin</surname><given-names>A. Ya.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Коровин Александр Яковлевич — доктор медицинских наук, профессор кафедры факультетской и госпитальной хирургии</p><p>ул. им. Митрофана Седина, д. 4, г. Краснодар, 350063</p></bio><bio xml:lang="en"><p>Alexander Ya. Korovin — Dr. Sci. (Med.), Prof., Department of Faculty and Hospital Surgery</p><p>Mitrofana Sedina str., 4, Krasnodar, 350063</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-0610-3516</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Базлов</surname><given-names>С. Б.</given-names></name><name name-style="western" xml:lang="en"><surname>Bazlov</surname><given-names>S. B.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Базлов Сергей Борисович — кандидат медицинских наук; доцент кафедры факультетской и госпитальной хирургии</p><p>ул. им. Митрофана Седина, д. 4, г. Краснодар, 350063</p></bio><bio xml:lang="en"><p>Sergey B. Bazlov — Cand. Sci. (Med.); Assoc. Prof., Department of Faculty and Hospital Surgery</p><p>Mitrofana Sedina str., 4, Krasnodar, 350063</p></bio><email xlink:type="simple">serb64@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-4643-9188</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Исаханян</surname><given-names>К. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Isakhanian</surname><given-names>K. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Исаханян Карен Армикович — ассистент кафедры факультетской и госпитальной хирургии</p><p>ул. им. Митрофана Седина, д. 4, г. Краснодар, 350063</p></bio><bio xml:lang="en"><p>Karen A. Isakhanian — Assistant, Department of Faculty and Hospital Surgery</p><p>Mitrofana Sedina str., 4, Krasnodar, 350063</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0009-0008-1835-0566</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Попандопуло</surname><given-names>И. К.</given-names></name><name name-style="western" xml:lang="en"><surname>Popandopulo</surname><given-names>I. K.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Попандопуло Иван Константинович — студент 6-го курса</p><p>ул. им. Митрофана Седина, д. 4, г. Краснодар, 350063</p></bio><bio xml:lang="en"><p>Ivan K. Popandopulo — 6th year student</p><p>Mitrofana Sedina str., 4, Krasnodar, 350063</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Федеральное государственное бюджетное образовательное учреждение высшего образования «Кубанский государственный медицинский университет» Министерства здравоохранения Российской Федерации</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Kuban State Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2024</year></pub-date><pub-date pub-type="epub"><day>18</day><month>06</month><year>2024</year></pub-date><volume>31</volume><issue>3</issue><fpage>44</fpage><lpage>56</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Попандопуло К.И., Коровин А.Я., Базлов С.Б., Исаханян К.А., Попандопуло И.К., 2024</copyright-statement><copyright-year>2024</copyright-year><copyright-holder xml:lang="ru">Попандопуло К.И., Коровин А.Я., Базлов С.Б., Исаханян К.А., Попандопуло И.К.</copyright-holder><copyright-holder xml:lang="en">Popandopulo K.I., Korovin A.Y., Bazlov S.B., Isakhanian K.A., Popandopulo I.K.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://ksma.elpub.ru/jour/article/view/3468">https://ksma.elpub.ru/jour/article/view/3468</self-uri><abstract><sec><title>Введение</title><p>Введение. Одним из важнейших факторов, определяющих развитие и степень тяжести внутрибрюшной гипертензии у больных с распространенным перитонитом, является повышение внутрипросветного давления в тонкой кишке вследствие паралитической кишечной непроходимости. Определение внутрипросветного давления в тонкой кишке представляет технически сложную проблему. Это является одной из причин отсутствия доказательных данных о влиянии величины интралюминального давления на степень выраженности внутрибрюшной гипертензии.</p><p>Цель исследования — оценить влияние величины внутрипросветного давления на степень выраженности внутрибрюшной гипертензии у больных с вторичным распространенным перитонитом.</p></sec><sec><title>Методы</title><p>Методы. Работа выполнена по дизайну наблюдательного клинического исследования на базе государственного бюджетного учреждения здравоохранения «Краевая клиническая больница скорой медицинской помощи» Министерства здравоохранения Краснодарского края в течение 07.2022–04.2024. Изучена динамика внутрибрюшного давления у 82 пациентов с распространенным перитонитом. У 34 из них (группа 1) при осуществлении назоинтестинальной интубации с помощью оригинального зонда определялось внутрипросветное давление в тонкой кишке до и после проведения декомпрессии. В группе 2 из 48 больных без выполнения назоинтестинальной интубации оценивались только показатели внутрибрюшного давления. Внутрибрюшное давление определяли через мочевой катетер методом Крона согласно рекомендациям World Society of the Abdominal Compartment Syndrome (WSACS). Степень тяжести перитонита определялась на основе использования прогностической шкалы World Society of Emergency Surgery complication Intra Abdominal Infecnions Score (WSES cIAIs Score). Статистический анализ: для сравнения порядковых показателей в разных группах или подгруппах использовали U-test Mann — Whitney, для сравнения количественных показателей с нормальным законом распределения — параметрический критерий Стьюдента.</p></sec><sec><title>Результаты</title><p>Результаты. У всех пациентов 1-й группы выявлено резкое повышение внутрипросветного давления в тонкой кишке, которое на 50 % определяло уровень внутрибрюшной гипертензии. При этом статистически значимой зависимости между степенью тяжести перитонита и выраженностью внутрибрюшной гипертензии не выявлено, что связано с разнообразием причин развития перитонита и давностью заболевания, которые определяют тяжесть паралитической кишечной непроходимости. Назоинтестинальная интубация у больных первой группы приводила к снижению внутрипросветного давления в среднем на 59,4 % сразу после проведения декомпрессии, что сопровождалось уменьшением показателей внутрибрюшного давления на 49,5 % от исходных. В группе 2 снижение внутрибрюшного давления происходило постепенно, и у большинства больных на протяжении первых 5–7 суток после операции его показатели соответствовали 2-й степени тяжести внутрибрюшной гипертензии.</p></sec><sec><title>Заключение</title><p>Заключение. Величина внутрипросветного давления в тонкой кишке определяет уровень внутрибрюшной гипертензии у больных с вторичным распространенным перитонитом. Величина внутрипросветного давления зависит от выраженности паралитической кишечной непроходимости и от характера патологии, послужившей причиной развития перитонита. Уровень внутрипросветного давления более 30 мм рт. ст. можно считать критическими показателями, приводящими к развитию выраженной внутрибрюшной гипертензии и синдрома абдоминальной компрессии. Назоинтестинальная декомпрессия тонкой кишки позволила добиться быстрого снижения показателей внутрибрюшного давления у больных 1-й группы до приемлемых значений и предотвратить развитие синдрома абдоминальной компрессии.</p></sec></abstract><trans-abstract xml:lang="en"><sec><title>Background</title><p>Background. An increased intraluminal pressure in the small intestine due to paralytic intestinal obstruction refers to one of the most important factors for development and severity of intra-abdominal hypertension in patients with diffuse peritonitis. Measurement of intraluminal pressure in the small intestine appears technically challenging, therefore, evidence on the effect of intraluminal pressure on the severity of intra-abdominal hypertension is yet to be gathered. Aim. To evaluate the influence of intraluminal pressure on the severity of intra-abdominal hypertension in patients with diffuse secondary peritonitis.</p></sec><sec><title>Methods</title><p>Methods. The research was performed according to the design of an observational clinical study on the basis of Regional Clinical Emergency Hospital, Krasnodar Krai, in the period of July 2022‒April 2024. The study considered dynamics of intra-abdominal pressure in 82 patients with diffuse peritonitis. Intraluminal pressure in the small intestine before and after decompression was measured in 34 patients (Group 1) when nasointestinal intubation was performed with the original tube. Group 2 included 48 patients subjected to measuring intra-abdominal pressure without nasointestinal intubation. The measurement of intra-abdominal pressure was performed through urinary catheterization using the Kron technique according to the recommendations of the World Society of the Abdominal Compartment Syndrome (WSACS). The severity of peritonitis was determined using the World Society of Emergency Surgery complication Intra-Abdominal Infections Score (WSES cIAIs Score). Statistical analysis and comparison of ordinal indices in different groups or subgroups were carried out by means of Mann-Whitney U-test; comparison of quantitative indices with normal distribution was performed using Student’s t-test.</p></sec><sec><title>Results</title><p>Results. All patients in Group 1 were detected with a sharp increase in intraluminal pressure in the small intestine, which appeared 50%-responsible for intra-abdominal hypertension. However, no statistically significant dependence between the severity of peritonitis and severity of intra-abdominal hypertension was revealed due to the variety of factors behind peritonitis development and duration of the disease, which determine the severity of paralytic intestinal obstruction. Nasointestinal intubation in Group 1 patients led to a decrease in intraluminal pressure on the average by 59.4% immediately after decompression, which was accompanied by a decrease in intra-abdominal pressure indices by 49.5% from the initial ones. In group 2, intra-abdominal pressure decreased gradually; during the first 5–7 post-operative days its indices in the majority of patients corresponded to the second degree of intra-abdominal hypertension severity.</p></sec><sec><title>Conclusion</title><p>Conclusion. The level of intraluminal pressure in the small intestine determines the level of intra-abdominal hypertension in patients with diffuse secondary peritonitis. Intraluminal pressure depends on the severity of paralytic intestinal obstruction and the pathology behind peritonitis. The level of intraluminal pressure over 30 mm Hg can be considered critical for the development of severe intra-abdominal hypertension and abdominal compression syndrome. In Group 1, nasointestinal decompression of the small intestine enabled intra-abdominal pressure to be rapidly reduced to acceptable level and development of abdominal compression syndrome to be prevented.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>внутрипросветное давление</kwd><kwd>внутрибрюшное давление</kwd><kwd>перитонит</kwd></kwd-group><kwd-group xml:lang="en"><kwd>intraluminal pressure</kwd><kwd>intra-abdominal pressure</kwd><kwd>peritonitis</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Батыршин И.М., Шляпников С.А., Демко А.Е., Остроумова Ю.С., Склизков Д.С., Фомин Д.В., Тишков А.В., Страх Л.В. Прогнозирование и дифференцированный подход в лечении больных с вторичным перитонитом и абдоминальным сепсисом. Хирургия. Журнал им. Н.И. 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