ksmaКубанский научный медицинский вестникKuban Scientific Medical Bulletin1608-62282541-9544Kuban State Medical Universityksma-609Research ArticleОБЗОРЫREVIEWРОЛЬ ВИРУСА ПАПИЛЛОМЫ ЧЕЛОВЕКА В РАЗВИТИИ РАКА РОТОГЛОТКИTHE ROLE OF HUMAN PAPILLOMAVIRUS IN DEVELOPMENT OF OROPHARYNGEAL CANCERСтуканьА. И.StukanA. I.noemail@neicon.ruБодняВ. Н.BodnyaV. N.noemail@neicon.ruДулинаЕ. В.DulinaE. V.noemail@neicon.ruЛеоновА. А.LeonovA. A.noemail@neicon.ruАлександровВ. И.AleksandrovV. I.noemail@neicon.ruГБОУ ВПО Куб ГМУ Минздрава РоссииRussian FederationГБУЗ «Клинический онкологический диспансер» № 1 министерства здравоохранения Краснодарского краяRussian Federation2016011020165154157Copyright © Стукань А.И., Бодня В.Н., Дулина Е.В., Леонов А.А., Александров В.И., 20162016Стукань А.И., Бодня В.Н., Дулина Е.В., Леонов А.А., Александров В.И.Stukan A.I., Bodnya V.N., Dulina E.V., Leonov A.A., Aleksandrov V.I.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://ksma.elpub.ru/jour/article/view/609

В статье представлен обзор зарубежной литературы по проблеме заболеваемости ВПЧ-ассоциированным раком ротоглотки. Эпидемиологические исследования демонстрируют увеличение случаев развития орофарингеальной плоскоклеточной карциномы (ОФПКК), особенно у белых мужчин среднего возраста. Такое увеличение заболеваемости раком ротоглотки в настоящее время связывают с вирусом папилломы человека (ВПЧ) 16-го типа. Маркером интеграции ДНК ВПЧ в ядерную ДНК человека выступает экспрессия белка р16. Предполагается, что определение ВПЧ-статуса опухоли будет иметь прогностическую значимость и создаст предпосылки для проведения профилактических мероприятий.

This article provides review of foreign literature on the problem of HPV-associated oropharyngeal cancer incidence. Epidemiological researches demonstrate increase of incidence of oropharyngeal squamous cell carcinoma (OPSCC) especially among white men of middle age. Such growth of oropharyngeal cancer incidence is associated with human papilloma virus type 16 (HPV 16). The p16 - protein expression is the marker of HPV DNA integration into human nuclear DNA. It is suggested that detection of tumor HPV-status can predict prognosis and develop preventive measures.

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The authors declare that there are no conflicts of interest present.