ksmaКубанский научный медицинский вестникKuban Scientific Medical Bulletin1608-62282541-9544Kuban State Medical Universityksma-636Research ArticleСтатьиСОВРЕМЕННЫЕ ПРЕДСТАВЛЕНИЯ О РОЛИ ЭПИТЕЛИАЛЬНО-МЕЗЕНХИМАЛЬНОГО ПЕРЕХОДА В ПРОГРЕССИИ ХРОНИЧЕСКОЙ БОЛЕЗНИ ПОЧЕКCURRENT UNDERSTANDING OF THE ROLE OF EPITHELIAL-MESENCHYMAL TRANSITION IN THE PROGRESSION OF CHRONIC KIDNEY DISEASEПотаповВ. Е.PotapovV. E.potapovvladimir0321@rambler.ruСинельникЕ. А.SinelnikE. A.noemail@neicon.ruАкименкоМ. А.AkimenkoM. A.noemail@neicon.ruПасечникД. Г.PasechnikD. G.noemail@neicon.ruРостовский государственный медицинский университетРоссияRostov State Medical UniversityRussian Federation2016011220166104109Copyright © Потапов В.Е., Синельник Е.А., Акименко М.А., Пасечник Д.Г., 20162016Потапов В.Е., Синельник Е.А., Акименко М.А., Пасечник Д.Г.Potapov V.E., Sinelnik E.A., Akimenko M.A., Pasechnik D.G.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://ksma.elpub.ru/jour/article/view/636

В данной статье приведен обзор полученных на сегодняшний день сведений, касающихся феномена эпителиально-мезенхимального перехода и его роли в формировании интерстициального фиброза почек, а так же механизмов его развития и возможных точек приложения для терапевтического воздействия. Особенно интересен в этом отношении оказался трансформирующий фактор роста-ß, по-видимому играющий одну из ключевых ролей в индукции эпителиально-мезенхимального перехода.

This article provides an overview of the currently acquired information concerning the phenomenon of epithelialmesenchymal transition and its role in the formation of interstitial kidney fibrosis and the mechanisms of its development and possible points of application to produce a therapeutic effect. Particularly interesting in this respect was the transforming growth factor-ß apparently plays a key role in induction of epithelial-mesenchymal transition.

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The authors declare that there are no conflicts of interest present.