References

ksma

Кубанский научный медицинский вестник

Kuban Scientific Medical Bulletin

1608-62282541-9544

Kuban State Medical University

ksma-647

Research Article

ОБЗОРЫ

REVIEW

БИОЛОГИЧЕСКАЯ АКТИВНОСТЬ ДИХЛОРАЦЕТАТА НАТРИЯ: КОНЦЕПЦИИ И МЕХАНИЗМЫ (ОБЗОР ЛИТЕРАТУРЫ)

THE BIOLOGICAL ACTIVITY OF SODIUM DICHLOROACETATE: CONCEPTS AND MECHANISMS (LITERATURE REVIEW)

Мануйлов

А. М.

Manuilov

A. M.

igor_ts@inbox.ru

Попов

К. А.

Popov

K. A.

igor_ts@inbox.ru

Цымбалюк

И. Ю.

Tsymbalyuk

I. Y.

igor_ts@inbox.ru

Литвинова

М. Г.

Litvinova

M. G.

igor_ts@inbox.ru

Хубиева

Ф. У.

Khubieva

F. U.

igor_ts@inbox.ru

Шестопалов

А. В.

Shestopalov

A. V.

noemail@neicon.ru

ФГБОУ ВО КубГМУ Минздрава РоссииРоссияKuban State Medical UniversityRussian Federation

Высшая школа молекулярной и экспериментальной медицины ФГБУ «ФНКЦДГОИ им. Дмитрия Рогачева» Минздрава РоссииРоссияDmitry Rogachev Federal Research CenterRussian Federation

2016

01122016

6156163

2016

Мануйлов А.М., Попов К.А., Цымбалюк И.Ю., Литвинова М.Г., Хубиева Ф.У., Шестопалов А.В.

Manuilov A.M., Popov K.A., Tsymbalyuk I.Y., Litvinova M.G., Khubieva F.U., Shestopalov A.V.

Данная работа распространяется под лицензией Creative Commons Attribution 4.0.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://ksma.elpub.ru/jour/article/view/647

Биологическая активность дихлорацетата натрия изучается в медицине на протяжении последних сорока пяти лет, между тем, представленный обзор является первым в отечественной литературе и призван привлечь внимание исследователей к данной проблематике. В экспериментально-клинических исследованиях демонстрируется эффективность дихлорацетата натрия как цитопротектора при ряде патологических процессов, сопровождающихся митохондриальной дисфункцией, а также противоопухолевая активность. Механизм его действия связан с активацией пируватдегидрогеназного комплекса и, как следствие, энергетического метаболизма. В нормальных клетках, находящихся в условиях гипоксии, это приводит к оптимизации расходования кислорода, предотвращению закисления среды. В атипичных клетках при этом происходит инверсия метаболизма с интенсификацией свободнорадикальных процессов, активацией каспазного ферментного каскада, снижением активности пропролиферативных и проангиогенетических транскрипционных факторов.

Though the biological activity of sodium dichloroacetate in medicine has been researched for the last forty-five years, our literature review is considered to be the first one in the domestic scientific literature and must draw the researchers' attention to this range of problems. During the clinic-experimental studies the effectiveness of sodium dichloroacetate as the cytoprotector in a number of pathological processes involving the mitochondrial dysfunction was researched as well as its antitumoral activity. The mechanism of its effect was associated with the activation of the pyruvate dehydrogenase complex and as a result of it the energy metabolism. In normal cells in the hypoxia conditions this leads to the optimization of oxygen consumption and the prevention of sulphur acidulation. In atypical cells this causes the metabolism inversion including the intensification of free-radical processes, the activation of caspase enzyme cascade, the activity lowering of proproliferative and proangiogenic transcriptional factors.

дихлорацетат натриямитохондриальная дисфункцияпируватдегидрогеназаметаболическая цитопротекцияsodium dichloroacetatemitochondrial dysfunctionpyruvate dehydrogenasemetabolic cytoprotection

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The authors declare that there are no conflicts of interest present.