NEW EXPERIMENTAL PATHOGENETICALLY GROUNDED VARICOCELE MODE
https://doi.org/10.25207/1608-6228-2018-25-2-40-44
Abstract
Aim. The main aim of the study was to develop a pathogenetically grounded varicocele model and to compare it with the well-known one.
Materials and methods. 30 male mongrel laboratory rats were divided in 3 equal groups, in the 1st group Saypol technique was performed, in the 2nd – one-time partial ligation of both spermatic cords with following testicles abdominisation. The 3rd group was the control one. There was a gonadectomy with following histological investigation on the 7th, 15th and 30th days.
Results. Group 1 was presented with adhesions in abdominal cavity and hydronephrosis in all rats. The changes in the spermatic veins and testicles were reached both in the 1st and 2nd groups with more signifi ones in the 2nd group by the 15th day. There were phlebectasia, tunica media thinning, infl infi of the testicles with spermatogenous epithelium and mature germ cells necrobiosis, in some cases also arterial vessels proliferation and even spermatogenesis recovery.
Conclusion. Thereby, the use of the suggested technique is more grounded from the technical, economical and pathogenetic points of view.
About the Authors
M. A. Berdnikov
State Educational Organisation of Higher Professional Education M. Gorky Donetsk National Medical University of the Ministry of Healthcare of the Donetsk People’s Republic
Ukraine
Ukraine
Mikhail A. Berdnikov, Department of Operative Surgery and Topographic anatomy
81/24, Tsusimskaya str., Donetsk 283052
N. V. Antipov
State Educational Organisation of Higher Professional Education M. Gorky Donetsk National Medical University of the Ministry of Healthcare of the Donetsk People’s Republic
Ukraine
Ukraine
Department of Operative Surgery and Topographic anatomy
Ilicha ave., 16, Donetsk, Donetsk People’s Republic, 283003
Yu. K. Gulkov
Donetsk Clinical Community-based Medical Organisation of the Ministry of Healthcare of the Donetsk People’sRepublic
Ukraine
Ukraine
Pathoanatomical Department
Ilicha ave., 14, Donetsk, Donetsk People’s Republic, 283003.
References
1. Ptashnyk G.I. Vplyv venoznoyi hipoksiyi na spermatogenez u eksperymenti. Svit medytsyny ta biologiyi. 2010; 1:42-45. (In Ukrainian).
2. Najari B.B., Li P.S., Ramasamy R. et al. Microsurgical rat varicocele model. Journal of Urology. 2014; 191: 548-553. DOI: 10.1016/j.juro.2013.08.011.
3. Zhou T., Cao H., Chen G., Yang B. , Sun Y. Outcomes of experimental rat varicocele with and without microsurgery. BMC Urology. 2015; 15(19). DOI: 10.1186/s12894-015-0012-y.
4. Ozturk M.I., Koca O., Keleş M.O., Haklar G., Baykan O., Ercan F. et al. The impact of unilateral experimental rat varicocele model on testicular histopathology, Leydig cell counts, and intratesticular testosterone levels of both testes. Urology Journal. 2013; 10(3): 973-980. DOI: https://doi.org/10.1016/S1569-9056(13)60197-9.
5. Katz M.J., Najari B.B., Li P.S., Goldstein M. The role of animal models in the study of varicocele. Translational Andrology and Urology. 2014; 3(1): 59-63. DOI: 10.3978/j.issn.2223-4683.2014.01.07.
6. Pivtorak V.I., Smiyukha O.A., Bulko M.P. Elektronnomikroskopichni zminy strukturnykh komponentiv yayechka pislya modelyuvannya varicotsele ta operatsiyi za vlasnym metodom. Tavricheskiy medico-biologicheskiy vestnik. 2013; 16(1), 2(61): 142-145. (In Ukrainian).
Review
For citations:
Berdnikov M.A., Antipov N.V., Gulkov Yu.K. NEW EXPERIMENTAL PATHOGENETICALLY GROUNDED VARICOCELE MODE. Kuban Scientific Medical Bulletin. 2018;25(2):40-44. (In Russ.) https://doi.org/10.25207/1608-6228-2018-25-2-40-44
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