COMPARATIVE ANALYSIS OF ACTOPROTECTIVE PROPERTIES OF NEW CHEMICAL COMPOUNDS
https://doi.org/10.25207/1608-6228-2019-26-2-122-129
Abstract
Aim. This study was aimed at searching and investigating new substances among phenylethyl derivatives of 3-hydroxypyridine, which exhibit a high actoprotective activity under the conditions of normoxia and acute hypobaric hypoxia.
Materials and methods. New compounds of phenylethyl derivatives of 3-hydroxypyridine under the SC code (n = 23) were investigated in comparison with bemethyl and bromantane. The actoprotective activity of new compounds was assessed in experimental animals using a treadmill running test under the conditions of normoxia and acute hypobaric hypoxia. The studied chemical substances and comparative drugs were administered 1 hour prior to exposure of animals to the test. Statistical processing of the obtained experimental results was performed using Microsoft Excel and Statistica for Windows 6.0 software.
Results. Among the studied substances, active compounds exhibiting an actoprotective effect have been distinguished. SC-119 chemical substance was revealed, which exceeds the other studied chemicals and bemethyl and bromantane reference actoprotectors in terms of the range of effective doses and actoprotective activity under the conditions of normoxia and acute hypobaric hypoxia.
Conclusion. According to the results of the study, the SC-119 compound seems to be a prospective candidate for further research into highly effective actoprotective drugs.
About the Authors
Elena N. Stratienko
Bryansk State Academician I. G. Petrovski University
Russian Federation
Russian Federation
Dr. Sci. (Med.), Prof., Department of Physical Education and the Basics of Medical Knowledge,
2 Sovetskiy lane, 17–4, Bryansk, 241050
Natalia P. Katunina
Bryansk State Academician I. G. Petrovski University
Russian Federation
Russian Federation
Dr. Sci. (Biology), Assoc. Prof., Department of Theory and Methods of Physical Culture and Sports,
Bezhitskaya str., 14, Bryansk, 241036
Fatima N. Tseeva
Bryansk State Academician I. G. Petrovski University
Russian Federation
Russian Federation
Cand. Sci. (Med.), Assoc. Prof., Department of Physical Education and the Basics of Medical Knowledge,
Bezhitskaya str., 14, Bryansk, 241036
Oksana V. Kukhareva
Bryansk State Academician I. G. Petrovski University
Russian Federation
Russian Federation
Cand. Sci. (Med.), Assoc. Prof., Department of Physical Education and the Basics of Medical Knowledge,
Bezhitskaya str., 14, Bryansk, 241036
Alexander V. Uvarov
Kuban State Medical University, Ministry of Healthcare of the Russian Federation
Russian Federation
Russian Federation
Cand. Sci. (Med.), Assoc. Prof., Department of Pharmacology,
Mitrofana Sedina str., 4, Krasnodar, 350063
Pavel A. Galenko-Yaroshevsky
Kuban State Medical University, Ministry of Healthcare of the Russian Federation
Russian Federation
Russian Federation
Dr. Sci. (Med.), RAS Correspondent Member, Prof., Head of Department, Department of Pharmacology,
Mitrofana Sedina str., 4, Krasnodar, 350063
Alexander V. Kiselev
Kuban State Medical University, Ministry of Healthcare of the Russian Federation
Russian Federation
Russian Federation
Cand. Sci. (Med.), Assoc. Prof., Department of Eye Diseases,
Mitrofana Sedina str., 4, Krasnodar, 350063
Anna G. Ovsyanikova
Kuban State Medical University, Ministry of Healthcare of the Russian Federation
Russian Federation
Russian Federation
Student, Pharmaceutical Department,
Mitrofana Sedina str., 4, Krasnodar, 350063
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Review
For citations:
Stratienko E.N., Katunina N.P., Tseeva F.N., Kukhareva O.V., Uvarov A.V., Galenko-Yaroshevsky P.A., Kiselev A.V., Ovsyanikova A.G. COMPARATIVE ANALYSIS OF ACTOPROTECTIVE PROPERTIES OF NEW CHEMICAL COMPOUNDS. Kuban Scientific Medical Bulletin. 2019;26(2):122-129. (In Russ.) https://doi.org/10.25207/1608-6228-2019-26-2-122-129
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