Prediction for vascular mild cognitive impairment using the p300 event-related potentials technique

Evoked potentials technique owing to informativeness and diagnostic value is widely used in clinical and experimental studies. Herein, we investigated whether the auditory P300 event-related potentials predict syndrome vascular mild cognitive impairment. 42 patients with I and II stages of discirulatory encephalopathy (50-70 years) included in clinical study. The discriminant analysis method was used to work out an equation with two variables as predictors - the P300 latent period and patient's age. The diagnostic accuracy of the discriminant equation at a cut-off -0,268 was established through receiver operating characteristic (ROC) analysis (sensitivity 80%, specificity 74,1%).

умеренные когнитивные расстройства, когнитивные расстройства цереброваскулярной этиологии, слуховые когнитивные вызванные потенциалы Р300, латентный период Р300, mild cognitive impairment, vascular cognitive impairment, the auditory P300 event-related potentials, P300 latent period

1. Дамулин И.В. Умеренные когнитивные расстройства: некоторые патогенетические, клинические и терапевтические аспекты // Consilium medicum и прилож. Неврология и ревматология. - 2008. - № 2. - С. 17-22.

2. Ланг Т.А., Сесик М. Как описывать статистику в медицине. Аннотированное руководство для авторов, редакторов и рецензентов. Пер. с англ. / Под ред. В.П. Леонова. - М.: Практическая медицина, 2011. - 480 с.

3. Левин О.С., Дударова М.А., Усольцева Н.И. Диагностика и лечение постинсультных когнитивных нарушений // Consilium medicum. - 2010. - № 2. - С. 5-12.

4. Яхно Н.Н. Дисциркуляторная энцефалопатия: Методические рекомендации. - М.: РКИ Соверо пресс, 2005. - 31 с.

5. Chertkow H., Massoud F., Nasreddine Z. et al. Diagnosis and treatment of dementia: 3. Mild cognitive impairment and cognitive impairment without dementia // CMAJ. - 2008. -May 6. № 178 (10). - P. 1273-1285.

6. Duncan C.C., Barry R.J., Connolly J.F. et al. Event-related potentials in clinical research: guidelines for eliciting, recording, and quantifying mismatch negativity, P300, and N400 // Clin. neurophysiol. - 2009. - Vol. 120. - P. 1883-1908.

7. Jackson C.E., Snyder P.J. Electroencephalography and event-related potentials as biomarkers of mild cognitive impairment and mild Alzheimer's disease // Alzheimers dement. - 2008. -Vol. 4 (1). Supplement 1. - P. 137-143.

8. Lonie J.A., Tierneу K.M., Ebmeier K.P. Screening for mild cognitive impairment: a systematic review // Int. j. geriatr. psychiatry. - 2009. - Vol. 24 (9). - P. 902-915.

9. Petersen R.C., Roberts R.O., Knopman D.S. et al. Mild cognitive impairment: Ten years later // Arch. neurol. - 2009. - Vol. 66 (12). - P. 1447-1455.

10. Pohjasvaara T., Erkinjuntti T., Vataja R., Kaste M. Dementia three months after stroke: baseline frequency and effect of different definitions of dementia in the helsinki stroke aging memory study (SAM) cohort // Stroke. - 1997. - Vol. 28. - P. 785-792.

11. Polich J. EEG and ERP assessment of normal aging // Electroencephalogr clin. neurophysiol. - 1997. - Vol. 104. -P. 244-256.

12. Polich J. Normal variation of P300 from auditory stimuli // Electroencephalogr clin. neurophysiol. - 1986. - Vol. 65 (3). -P. 236-240.

13. Roman G.C., Tatemichi T.K., Erkinjunitti T. et al. Vascular dementia: Diagnostic criteria for research studies. Report of the NINDS-AIREN International workshop // Neurology. - 1993. - Feburary 1. № 43 (2). - P. 250-260.

14. Winblad B., Palmer K., Kivipelto M. et al. Mild cognitive impairment - beyond controversies towards a consensus: report of the international working group on mild cognitive impairment // J. intern. med. - 2004. - Vol. 256 (3). - P. 240-246.