Estimation of functional adaptation of the transplanted heart in an organism of the recipient

Significant development of the heart transplantation in clinical practice allowed implementing these types of surgery in most of the major cardiac clinics in the world. This happened because of the improvement of surgical techniques, artificial blood-circulation apparatuses and especially immunosuppression methods. It goes without saying, that these achievements raise the new questions. One of the most important one among them is the recovery of extracardiac regulation, especially the nerve regulatory effect on the transplanted heart. Six months after surgery we've examined 10 patients. Cardiorespiratory synchronism was not detected among all the patients, primary pacemaker in the sinoatrial region of the heart showed no reaction to the Danini-Aschner reflex. These facts showed no signs of the heart's functional reinnervation and recovery of mechanisms of the heart rhythmogenesis hierarchical organization. At the same time, changes in heart rate variability of these patients gave us the reason to assume a manifestation of the initial stages of incorporating the central nervous system influences to the heart rate. The spectral analysis of heart rate variability among these patients showed that TP ms² they amounted 152,45 ± 13,48; HF ms² - 59,85 ± 25,02 and VLF ms² - 74,55 ± 33,16.

трансплантация сердца, адаптация трансплантированного сердца, реиннервация трансплантированного сердца, heart transplantation, adaptation of the transplanted heart, reinnervation of the transplanted heart

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