Markers of saliva secretory immunity of persons of different age, lives in St. Petersburg and Leningrad region
Abstract
In the article evaluated the performance of the secretory immune saliva, 109 people of different ages (from 20 to 90 years), residing in St. Petersburg and Leningrad region do not have diseases of the salivary glands. The content in saliva immunoglobulins IgA, IgM, IgG and secretory IgA, and pro-inflammatory (IL -1β, interleukin-6, interleukin-8, tumor necrosis factor-α) and anti-inflammatory (interleukin-1 receptor antagonist, interleukin-4, interleukin-10) cytokines by ELISA. The study established that the level of sIgA in saliva increases with age, reaching maximum values in a group of elderly people, but to people senile age content of sIgA in saliva dropped. In patients of elderly and senile age there are changes in the content of cytokines in saliva: elevated levels of proinflammatory IL-1β and TNFα and anti-IL-10, with a simultaneous decrease of IL-8 (the main chemotactic factor for neutrophils). These changes may cause an imbalance in the local immune response to the pathogen and development of both autoimmune and inflammatory diseases of the oral cavity.
About the Authors
V. V. Lobeyko
Military medical academy
Russian Federation
Russian Federation
A. K. Iordanishvili
Institute of bioregulation andgerontolorgii
Russian Federation
Russian Federation
M. E. Malyshev
Saint-Peterburg I.I. Dzhanelidze research Institute of emergency
Russian Federation
Russian Federation
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Review
For citations:
Lobeyko V.V., Iordanishvili A.K., Malyshev M.E. Markers of saliva secretory immunity of persons of different age, lives in St. Petersburg and Leningrad region. Kuban Scientific Medical Bulletin. 2015;(1):74-79. (In Russ.)
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