Current view of the inhibitor protein cyclin-dependent kinase р16, р27 and their role in the cell cycle
Abstract
Violations of the cell cycle have their own characteristics in the skin lesions. The greatest attention is paid to the research of cancers, whereas benign tumors of the skin insufficiently studied. The article presents data on the characteristics of protein expression of cyclin dependent kinase inhibitor p16, p27, and their role in the cell cycle and oncogenesis.
About the Authors
A. K. Aleksandrova
I.M. Sechenov First Moskow State Medical University
Russian Federation
Russian Federation
V. A. Smolynnikova
I.M. Sechenov First Moskow State Medical University
Russian Federation
Russian Federation
References
1. Bishop J. M. // Cell. - 1991. - V. 64. - Р. 235-248.
2. Levine A. J. // An. rev. biochem. - 1993. - V. 62. -Р. 623-651.
3. Rabbits T. H. // Nature. - 1994 - V. 72. - P. 143-149.
4. Morgan David. The cell cycle: principals of control. -London: New science press LTD, 2007.
5. Morgan D. O. // An. rev. cell dev. biol. - 1997. - V. 13. -P. 261-291.
6. Sherr C. J. // Science. - 1996. - V. 274. - P. 1672-1677.
7. Serrano M., Lee H., Chin L., Cordon-Cardo C., Beach D., DePinho RA. Role of the INK4a locus in tumor suppression and cell mortality // Cell. - 1996. - V. 85. - P. 27.
8. Rayess H., Wang M. B., Srivatsan E. S. Cellular senescence and tumor suppressor gene p16 // Int. j. cancer - 2012. -V. 130 (8). - P. 171-174.
9. Rosso A. A, Tong L., Lee J. O., Jeffrey P. D., Pavletich N. P. Struktural basis for inhibition of the ciklin-dependent kinase Cdk6 by the tumour suppressor p16/INK4A // Nature. - 1998. - V. 395. - P. 237-243.
10. Liggett W. H., Sidransky D. Role of the p16 tumor suppressor gene in cancer // J. clin. oncol. - 1998. - V. 16 (3). -P. 1197-1206.
11. Cioffi-Lavina M., Chapman-Fredricks J., Gomez-Fernandez C., Ganjei-Azar P., Manoharan M., Jorda M. P16 expression in squamous cell carcinomas of cervix and bladder // Appl. immunohistochem. mol. morphol. - 2010. - V. 18 (4). - P. 344-347.
12. Hafner C., Vogt T. Seborrheic keratosis // J. dtsch. dermatol. ges. - 2008. - V. 6 (8). - P. 664-677.
13. Wolff K., Goldsmith L. A., et al. Fitzpatricks dermatology in general medicine, seventh edition // McGraw-hill medical. - 2012.
14. Liu Y., Sanoff H. K., Cho H., Burd C. E., Torrice C., Ibrahim J. G., Thomas N. E., Sharpless N. E. Expression of p16(INK4a) Кубанский научный медицинский вестник № 1 (156) 2016 УДК 616.314.17-08:615.2]-059.2 Кубанский научный медицинский вестник № 1 (156) 2016 in peripheral blood T-cells is a biomarker of human aging // Aging cel. - 2009. - V. 8 (4). - P. 439-448.
15. Roussel M. F. The INK4 family of cell cycle inhibitors in cancer // Oncogene. - 1999. - V. 18 (38). - P. 5311-5312.
16. Nakamura S., Nishioka K. Enhanced expression of p16 in seborrhoeic keratosis; a lesion of accumulated senescent epidermal cells in G1 arrest // Br. j. dermatol. - 2003. - Sep. V. 149 (3). - P. 560-565.
17. Bruecks A. K., Kalia S., Trotter M. J. Overexpression of p27KIP1 in seborrheic keratosis // J. cutan. med. surg. - 2007. -Sep.-oct. V. 11 (5). - P. 174-178.
18. Wu Y. H.1, Hsiao P. F., Chen C. K. Seborrheic keratosis with bowenoid transformation: The immunohistochemical features and its association with human papillomavirus infection // Am. j. dermatopathol. - 2015. - V. 17. - P. 45-48.
19. Mitrea D. M., Yoon M. K., Ou L., Kriwacki R. W. Disorderfunction relationships for the cell cycle regulatory proteins p21 and p27 // Biol. chem. - 2012. - V. 393 ( 4). - P. 259-274.
20. Sanchez-Garcia I. // An. rev. genet. - 1997. -V. 31. - P. 429-453.
21. Dyson N., Baiman A. Oncogenes and cell proliferation // Current ooinion in genetics and development. - 1999. - V. 9. -P. 11-14.
22. Pellegata N. S., Quintanilla-Martinez L., Siggelkow H., Samson E., Bink K., Höfler H., Fend F., Graw J., Atkinson M. J. Germ-line mutations in p27Kip1 cause a multiple endocrine neoplasia syndrome in rats and humans // Proc. natl. acad. sci. USA. - 2006. - V. 103. - P. 15558-15563.
23. Lodish Harvey, et al. Molecular cell biology/ 6th. - New York city: W. H. Freeman and Company, 2008.
24. Li M., Cheng R., Shi M., Liu J., Zhang G., Liu Q., Yu H., Yao Z. Analyses of FLG mutation frequency and filaggrin expression in isolated ichthyosis vulgaris (IV) and atopic dermatitis-associated IV // Br. j. dermatol. - 2013. - V. 168 (6). - P. 1335-1338.
Review
For citations:
Aleksandrova A.K., Smolynnikova V.A. Current view of the inhibitor protein cyclin-dependent kinase р16, р27 and their role in the cell cycle. Kuban Scientific Medical Bulletin. 2016;(1):7-9. (In Russ.)
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