Local cytokine status with laboratory animals in various periods after intraocular shape memory implant administration in experimental ophthalmology

Abstract

Experimental estimation of pro- and anti-inflammatory cytokines balance in aqueous eye chamber liquid in case of intraocular implantation of drainage material made of nickelid titanium and intraocular application of a solid retention suture TH-10. Investigation of aqueous eye chamber liquid sampled on the 3rd, 7th and 30th days and in 3 months and in 1,5 year after intraocular implantation with nickelid titanium TH-10 used as a drainage and fixative device have been studied during experiment with 26 mature rabbits. The control group consisted of 6 intact rabbits as well as of 5 rabbits for whom perforating hypotensive surgical interference without drainage device implantation have been administered in various periods of monitoring. The opposite nature of cytokines balance changes and proportion of its pro- and anti-inflammatory element in the dynamics after intraocular implantation of a nickelid titanium and solid suture TH-10, which shows positive anti-inflammatory influence of materials made of nickelid titanium basis, that is manifested in significant reduction of anti-inflammatory component of cytokines balance and shows its maximum in the utmost tardy periods of monitoring, as well in clinically unresponsive postoperative course with animals of experimental group compared to the group of comparison.