EVALUATION OF THE EXPRESSION OF TRANSCRIPTION, NEOANGIOGENESIS AND APOPTOSIS FACTORS IN CASE OF POSTOPERATIVE COMPLICATIONS IN PATIENTS WITH DIFFERENT PROGRESSION OF ORAL MUCOSA CANCER
https://doi.org/10.25207/1608-6228-2017-1-64-68
Abstract
While studying the expression of transcription, neoangiogenesis and apoptosis factors in the tumour tissue and oral fluid of 141 patients with oral mucosa cancer T1-3N0-2M0, it was shown that oral mucosa cancer progression combined with postoperative purulent inflammatory complications were associated with a high level of transcription factors, enhanced translocation of hypoxia-inducible factor-1б in the core, high expression of vascular endothelial growth factor and activation of apoptosis in the tumour tissue. The revealed changes in the underlying disease progression have a reasonably greater severity.
About the Authors
V. I. KONONENKO
Rostov Research Institute of Oncology
Russian Federation
Rostov-on-Don, 14 Line, 63, tel. 8 (632) 300-30-05
Russian Federation
Rostov-on-Don, 14 Line, 63, tel. 8 (632) 300-30-05
O. I. KIT
Rostov Research Institute of Oncology
Russian Federation
Rostov-on-Don, 14 Line, 63, tel. 8 (632) 300-30-05
Russian Federation
Rostov-on-Don, 14 Line, 63, tel. 8 (632) 300-30-05
E. F. KOMAROVA
Rostov Research Institute of Oncology
Russian Federation
Rostov-on-Don, 14 Line, 63, tel. 8 (632) 300-30-05
Russian Federation
Rostov-on-Don, 14 Line, 63, tel. 8 (632) 300-30-05
A. Yu. MAKSIMOV
Rostov Research Institute of Oncology
Russian Federation
Rostov-on-Don, 14 Line, 63, tel. 8 (632) 300-30-05
Russian Federation
Rostov-on-Don, 14 Line, 63, tel. 8 (632) 300-30-05
V. V. POZDNYAKOVA
Rostov Research Institute of Oncology
Russian Federation
Rostov-on-Don, 14 Line, 63, tel. 8 (632) 300-30-05
Russian Federation
Rostov-on-Don, 14 Line, 63, tel. 8 (632) 300-30-05
I. A. NOVIKOVA
Rostov Research Institute of Oncology
Russian Federation
Rostov-on-Don, 14 Line, 63, tel. 8 (632) 300-30-05
Russian Federation
Rostov-on-Don, 14 Line, 63, tel. 8 (632) 300-30-05
A. A. DEMIDOVA
Rostov Research Institute of Oncology
Russian Federation
Rostov-on-Don, 14 Line, 63, tel. 8 (632) 300-30-05
Russian Federation
Rostov-on-Don, 14 Line, 63, tel. 8 (632) 300-30-05
References
1. Кононенко В. И., Кит О. И., Комарова Е. Ф., Максимов А. Ю. Состояние факторов врожденной иммунной защиты ротовой полости, транскрипционной активности опухолевых клеток у больных раком слизистой оболочки полости рта с гнойно- септическими осложнениями // Стоматология. – 2015. – Т. 94. – № 6. – С.7.
2. Пачес А. И. Опухоли головы и шеи. Клиническое руководство. // Издательский дом «Практическая медицина». – 2013. – 278 с.
3. Спирина Л.В., Чойнзонов Е.Л., Кондакова И.В., Шишкин Д.А., Чижевская С.Ю. Экспрессия транскрипционных факторов NF-kB и HIF-1 в плоскоклеточных карциномах головы и шеи: связь с прогнозом заболевания/ // Вопросы онкологии. – 2013. – № 5. – С.575–579.
4. Huang C., Sun Z., Sun Y., Chen X. et al. Association of increased ligand cyclophilin A and receptor CD147 with hypoxia, angiogenesis, metastasis and prognosis of tongue squamous cell carcinoma. // Histopathology. – 2012. – Vol. 60. – P.793-803.
5. Kang F.W., Gao Y., Que L., Sun J., Wang Z.L. Hypoxiainducible factor-1α overexpression indicates poor clinical outcomes in tongue squamous cell carcinoma./ // Exp. ther. med. – 2013. – V.5. – P.112–118.
6. Liang X.H., Zheng M., Jiang J.A., Zhu G.Q., Yang J., Tang Y.L. Hypoxia – inducible factor-1 alpha, in association with TWIST2 and SNIP1, is a critical prognostic factor in atients with tongue squamous cell carcinoma // Oral. oncol. – 2011. – V.47. – P. 92–97.
7. Margaritescu C., Pirici, D., Stоngг, A. et al. VEGF expression and angiogenesis in oral squamous cell carcinoma: an immunohistochemical and morphometric study // Clin. Exp. Med. – 2010. – Vol. 10. – P. 209.
8. Mohamed K.M., Le A., Duong H., Wu Y., Zhang Q., Messadi D.V. Correlation between VEGF and HIF-1б expression in human oral squamous cell carcinoma // Exp. mol. pathol. – 2004. – V.76. – P.143-152
9. Perez-Sayans M., Suбrez-Peсaranda J.M., Pilar G.D., Barros-Angueira F. Hypoxia-inducible factors in OSCC //Cancer letters. – 2011. – Vol. 313, № 1. – P.1–8.
10. Shang Z.J., Li J.R., Li Z.B. Up-regulation of serum and tissue vascular endothelial growth factor correlates with angiogenesis and prognosis of oral squamous cell carcinoma // J. Oral. maxillofac. surg. – 2007. – Vol.65. – P.17–21.
11. Siriwardena B.S., Tilakaratne A., Amaratunga E.A., Tilakaratne W.M. Demographic, aetiological and survival differences of oral squamous cell carcinoma in the young and the old in Sri Lanka // Oral Oncologyl. – 2006. – Vol. 42. – P. 831–6.
12. Smith BD, Smith GL, Carter D, Sasaki CT, Haffty BG Prognostic significance of vascular endothelial growth factor protein levels in oral and oropharyngeal squamous cell carcinoma. // J Clin Oncol. – 2000. – № 18. – P. 2046–2052.
13. Uden P., Kenneth N.S., Rocha S. Regulation of hypoxiainducible factor-1 alpha by NF- kappaB // Biochem. J. – 2008. – Vol. 412(3). – P. 477–484.
Review
For citations:
KONONENKO V.I., KIT O.I., KOMAROVA E.F., MAKSIMOV A.Yu., POZDNYAKOVA V.V., NOVIKOVA I.A., DEMIDOVA A.A. EVALUATION OF THE EXPRESSION OF TRANSCRIPTION, NEOANGIOGENESIS AND APOPTOSIS FACTORS IN CASE OF POSTOPERATIVE COMPLICATIONS IN PATIENTS WITH DIFFERENT PROGRESSION OF ORAL MUCOSA CANCER. Kuban Scientific Medical Bulletin. 2017;1(1):64-68. (In Russ.) https://doi.org/10.25207/1608-6228-2017-1-64-68
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