COL1A1 GENE SP1 POLYMORPHISM AND OSTEOPOROSIS RISK IN POSTMENOPAUSAL WOMEN
https://doi.org/10.25207/1608-6228-2017-1-90-94
Abstract
483 postmenopausal women took part in survey. It was established that GG genotype and G allele of COL1A1 gene 1546 (6252) G>T [Sp1 S>s] polymorphism provide protective effect for osteoporotic changes development at L1-L4 lumbar vertebrae, forearm distal department, left and right femurs proximal departments, including femoral neck. GT genotype and T allele of above-stated polymorphism are postmenopausal osteoporosis predictors in various sites of skeleton. The obtained data can be used for detection of predisposition to osteoporosis development at postmenopausal women and treatment-and-prophylactic actions efficiency rising.
About the Author
E. A. MAYLYAN
Donetsk National Medical University named after M. Gorky
Russian Federation
Russian Federation
Department of Clinical Immunology, Allergology and Endocrinology
283003, Donetsk, Illicha Ave., 16; tel. +38-095-578-72-27
References
1. Зябліцев С. В., Ларін О. С., Зябліцев Д. С., Чернобривцев П. А. Визначення ролі поліморфізму Sp1 (rs1800012) гена COL1A1 при постменопаузальному остеопорозі // Клінічна ендокринологія та ендокринна хірургія. – 2016. – Т. 53, № 1. – С. 47–52.
2. Майлян Э. А. Мультифакторность этиопатогенеза остеопороза и роль генов канонического WNT-сигнального пути // Остеопороз и остеопатии. – 2015. – № 2. – С. 15–19.
3. Майлян Э. А., Майлян Д. Э. Основы молекулярной генетики и генетические факторы риска заболеваний женщин // Медицинский вестник Юга России. – 2016. – № 1. – С. 33–40.
4. Хусаинова Р. И., Селезнева Л. И., Валиев Р. Р., Хуснутдинова Э. К. Изучение молекулярно-генетических основ развития постменопаузального остеопороза в Волго-Уральском регионе // Медицинская генетика. – 2009. – № 5. – С. 12–19.
5. Dehghan M., Pourahmad-Jaktaji R. Sp1 binding site polymorphism of a collagen gene (rs1800012) in women aged 45 and over and its association with bone density // Turk. j. med. sci. – 2015. – Vol. 45, № 3. – Р. 644–650.
6. Dytfeld J., Marcinkowska M., Drwęska-Matelska N., Michalak M., Horst-Sikorska W., Słomski R. Association analysis of the COL1A1 polymorphism with bone mineral density and prevalent fractures in Polish postmenopausal women with osteoporosis // Arch. med. sci. – 2016. – Vol. 12, № 2. – P. 288–294.
7. Falcón-Ramírez E., Hidalgo-Bravo A., Barredo-Prieto B. A., Pineda-Gómez E., Valdés-Flores M. Association of the COL1A1 gene polymorphisms in Mexican postmenopausal women with fracture or with low bone mineral density at the hip // Aging clin. exp. res. – 2016. – Vol. 28, № 3. – Р. 567–571.
8. Jin H., Evangelou E., Ioannidis J. P., Ralston S. H. Polymorphisms in the 5' flank of COL1A1 gene and osteoporosis: meta-analysis of published studies // Osteoporos. int. – 2011. – Vol. 22, № 3. – P. 911–921.
9. Kurt-Sirin O., Yilmaz-Aydogan H., Uyar M., Seyhan M. F., Isbir T., Can A. Combined effects of collagen type I alpha1 (COL1A1) Sp1 polymorphism and osteoporosis risk factors on bone mineral density in Turkish postmenopausal women // Gene. – 2014. – Vol. 540, № 2. – Р. 226–231.
10. Majchrzycki M., Bartkowiak-Wieczorek J., Wolski H., Drews K., Bogacz A., Czerny B., Zagrodnik-Ułan E., Seremak-Mrozikiewicz A. Polymorphisms of collagen 1A1 (COL1A1) gene and their relation to bone mineral density in postmenopausal women // Ginekol. Pol. – 2015. – Vol. 86, № 12. – P. 907–914.
11. Rodriguez S., Gaunt T. R., Day I. N. Hardy-Weinberg equilibrium testing of biological ascertainment for Mendelian randomization studies // Am. j. epidemiol. – 2009. – Vol. 169, № 4. – Р. 505–514.
12. Rojano-Mejía D., Coral-Vázquez R. M., Espinosa L. C., López-Medina G., Aguirre-García M. C., Coronel A., Canto P. JAG1 and COL1A1 polymorphisms and haplotypes in relation to bone mineral density variations in postmenopausal Mexican-Mestizo Women // Age (Dordr.). – 2013. – Vol. 35, № 2. – Р. 471–478.
13. Urano T., Inoue S. Genetics of osteoporosis. Biochem. Biophys // Res. commun. – 2014. – Vol. 452, № 2. – Р. 287–293.
14. Zhang L. Q., Liu H., Huang X. F. Relation of JAGGED 1 and collagen type 1 alpha 1 polymorphisms with bone mineral density in Chinese postmenopausal women // Int. j. clin. exp. pathol. – 2014. – Vol. 7, № 10. – Р. 7142–7147.
Review
For citations:
MAYLYAN E.A. COL1A1 GENE SP1 POLYMORPHISM AND OSTEOPOROSIS RISK IN POSTMENOPAUSAL WOMEN. Kuban Scientific Medical Bulletin. 2017;1(1):90-94. (In Russ.) https://doi.org/10.25207/1608-6228-2017-1-90-94
Views:
430
Email this article 