LABORATORY AND GENETIC PREDICTION OF THE RISK OF ATRIAL FIBRILLATION IN PATIENTS WITH CORONARY HEART DISEASE
https://doi.org/10.25207/1608-6228-2017-1-106-109
Abstract
The paper studied the frequency of polymorphisms of hemostasis in patients with coronary heart disease, living in the Krasnodar region. Of the 13 patients with atrial fibrillation documented confirmed, 11 patients revealed mutations of genes of the hemostatic system (84.61 %), while 10 patients out of 11 had a mutation MTRR mutation (90.9 %), and met mutations in polygenic 10 cases (90.9 %). It is shown that the most common mutation MTRR gene, PAI, VII factor and beta fibrin often cause arrhythmias in patients enhance remodeling of the left ventricle, especially in polygenic mutations.
About the Authors
D. I. PANCHENKO
FGBOU IN Kuban State Medical University, Russian Ministry of Health
Russian Federation
Russian Federation
Department of Internal Medicine Propaedeutics
350063, Krasnodar, Sedin str., 4; tel. +7 (861) 268-36-84
A. S. ADAMCHIK
FGBOU IN Kuban State Medical University, Russian Ministry of Health
Russian Federation
Russian Federation
Department of Internal Medicine Propaedeutics
350063, Krasnodar, Sedin str., 4; tel. +7 (861) 268-36-84
References
1. Баранов В. С. Генетические основы предрасположенности к некоторым частым мультифакториальным заболеваниям // Медицинская генетика. – 2004. – Т. 3. – С.102– 112.
2. Баркаган З. С., Костюченко Г. И., Котовщикова, Е. Ф. Гипергомоцистеинемия как самостоятельный фактор риска поражений и тромбирования кровеносных сосудов // Ангиология и сосудистая хирургия. – 2002. – № 1. – С. 65–71.
3. Шевела А. И., Севостьянова К.С., Новикова Я.В., Воронина Е.Н. Основные тенденции распределения протромботических полиморфизмов генов у пациентов с флеботромбозами г. Новосибирска // Экология человека 2010. – № 7. – С.36–41.
4. Ioannidis, I. P. Genetic associations: false or true? // Trend Mol. Med. – 2003. – V.9. – № 4. – P.136–138.
5. Kucukarabaci B., Gunes H. V., Ozdemir G. et al. Investigation of Association between Plasminogen Activator Inhibitor Type-1 (PAI-1) Gene 4G/5G Polymorphism Frequency and Plasma PAI-1 Enzyme Activity in Patients with Acute Stroke // Genetic Testing. – 2008. – № 12: 443–451.
6. Miao C. H., Leytus, S. P., Chung D. W., Davie E. W. Liverspecific expression of the gene coding for human factor X, a blood coagulation factor //J Biol Chem. – 1992; 267: 11: 7395–7401.
7. WHO Global InfoBase. URL: http://infobase.wno.int.
Review
For citations:
PANCHENKO D.I., ADAMCHIK A.S. LABORATORY AND GENETIC PREDICTION OF THE RISK OF ATRIAL FIBRILLATION IN PATIENTS WITH CORONARY HEART DISEASE. Kuban Scientific Medical Bulletin. 2017;1(1):106-109. (In Russ.) https://doi.org/10.25207/1608-6228-2017-1-106-109
Views:
300
Email this article 