INFLUENCE OF THE COMPOUND SS-68 ON THE ELECTROPHYSIOLOGICAL EFFECTS OF ADRENOMIMETICS IN RAT RIGHT ATRIUM
https://doi.org/10.25207/1608-6228-2017-2-24-29
Abstract
The influence of compound SS-68, known for its marked antiarrhythmic properties, on the intension of electrophysiological effects of α1- и β- adrenoreceptors stimulation was studied in right atrial preparations from rat. Activation of α1-adrenoreceptors by methoxamine (3×10-5М) led to prominent prolongation of action potentials without significant changes in their rhythm. SS-68 attenuated this effect with IC50 = 5,27×10-6М. The standard α1-blocker prazosine appeared to be more effective (IC50 = 2×10-7М). The activation of β-adrenoreceptors by isoproterenol (3×10-7М) led to drastic acceleration of sinus rhythm. However, only the highest tested concentration of SS-68 (3×10-5М) reduced this effect, while the conventional β-blocker atenolol effectively inhibited it with IC50 = 3,95×10-6М.
About the Authors
S. K. BOGUS
Kuban state medical university
Russian Federation
Russian Federation
Department of pharmacology
Russia, 350063, Krasnodar, Sedina str., 4; tel. +7-928-429-21-22
D. V. ABRAMOCHKIN
Lomonosov Mockow state university
Russian Federation
Russian Federation
2department of human and animal physiology
Russia, 119991, Moscow, Leninskie Gory, 1; tel. +7-916-603-05-02
A. V. ZELENSKAYA
Kuban state medical university
Russian Federation
Russian Federation
Department of pharmacology
Russia, 350063, Krasnodar, Sedina str., 4; tel. +7-928-429-21-22
K. F. SUZDALEV
Southem Federal university
Russian Federation
Russian Federation
department of natural and high molecular compounds chemistry
Russia, 344090, Rostov on Don, Zorge str., 7; tel. +7-918-865-71-00
P. A. GALENKO-YAROSHEVSKY
Kuban state medical university
Russian Federation
Russian Federation
Department of pharmacology
Russia, 350063, Krasnodar, Sedina str., 4; tel. +7-928-429-21-22
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Review
For citations:
BOGUS S.K., ABRAMOCHKIN D.V., ZELENSKAYA A.V., SUZDALEV K.F., GALENKO-YAROSHEVSKY P.A. INFLUENCE OF THE COMPOUND SS-68 ON THE ELECTROPHYSIOLOGICAL EFFECTS OF ADRENOMIMETICS IN RAT RIGHT ATRIUM. Kuban Scientific Medical Bulletin. 2017;1(2):24-29. (In Russ.) https://doi.org/10.25207/1608-6228-2017-2-24-29
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