DISSOLUTION TEST IN QUALITY ASSESSMENT OF TABLETS CONTAINING 11-DEOXYMISOPROSTOL
https://doi.org/10.25207/1608-6228-2018-25-1-129-132
Abstract
Aim. Development of the dissolution test method of 11-deoxymisoprostol tablets.
Materials and methods. The research was carried out on a "paddle apparatus". The media dissolution temperature is 37±0,5 degrees, the stirring rate is 50 rpm, the sampling time is 45 minutes, the dissolution media volume is 500 ml. The method of quantitative determination of 11-deoxymisoprostol in sample solution – HPLC with UV-detection, reverse phase chromatography. Chromatograph "Shimadzu Prominence LC-20" (Japan) with a matrix photodiode detector SPD20, column Discovery C18 (5 μm; 150 mm x 4.6 mm), mobile phase: water-acetonitrile (50:50), isocratic elution, detection at a wavelength of 195 nm.
Results. All tested tablet samples meet the requirements of the State Pharmacopoeia in terms of "Dissolution test".
Conclusion. A dissolution test method of 11-deoxyimisoprostol tablets has been developed.
About the Authors
A. A. FEDOTOVA
Federal State Budgetary Educational Institution of Higher Education "Bashkir State Medical University", Ministry of Healthcare of the Russian Federation.
Russian Federation
Russian Federation
Pushkin str., 96/98, Ufa, 450008.
A. G. YALKAEV
Federal State Budgetary Educational Institution of Higher Education "Bashkir State Medical University", Ministry of Healthcare of the Russian Federation.
Russian Federation
Pushkin str., 96/98, Ufa, 450008.
Russian Federation
Pushkin str., 96/98, Ufa, 450008.
V. A. KATAEV
Federal State Budgetary Educational Institution of Higher Education "Bashkir State Medical University", Ministry of Healthcare of the Russian Federation.
Russian Federation
Pushkin str., 96/98, Ufa, 450008.
Russian Federation
Pushkin str., 96/98, Ufa, 450008.
R. A. KHALIKOV
Federal State Budgetary Educational Institution of Higher Education "Bashkir State Medical University", Ministry of Healthcare of the Russian Federation.
Russian Federation
Pushkin str., 96/98, Ufa, 450008.
Russian Federation
Pushkin str., 96/98, Ufa, 450008.
F. Kh. KILDIYAROV
Federal State Budgetary Educational Institution of Higher Education "Bashkir State Medical University", Ministry of Healthcare of the Russian Federation.
Russian Federation
Pushkin str., 96/98, Ufa, 450008.
Russian Federation
Pushkin str., 96/98, Ufa, 450008.
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Review
For citations:
FEDOTOVA A.A., YALKAEV A.G., KATAEV V.A., KHALIKOV R.A., KILDIYAROV F.Kh. DISSOLUTION TEST IN QUALITY ASSESSMENT OF TABLETS CONTAINING 11-DEOXYMISOPROSTOL. Kuban Scientific Medical Bulletin. 2018;25(1):129-132. (In Russ.) https://doi.org/10.25207/1608-6228-2018-25-1-129-132
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