Vascular endothelial dysfunction and comorbid conditions in bronchial asthma

Abstract

We have examined 35 patients with bronchial asthma (BA), 35 patients with ischemic heart disease (IHD), 35 patients with arterial hypertension (AH), 40 patients with a combination of BA+IHD and 40 patients with a combination of BA+AH. To assess the state of vascular endothelium in the laser Doppler flowmetry supplemented with iontophoretic samples, we calculated the coefficient of endothelial function. it has been proved that the comorbid combination of BA and IHD is significantly unfavorable regarding the severity of vascular endothelial dysfunction, both compared with mononozology (BA) and compared with the combination of BA+AH. The attachment of AH significantly worsens the condition of the vascular endothelium in patients with BA. Endothelial dysfunction may act as a predisposing factor for IHD in patients with BA.