PROSPECTS FOR THE DEVELOPMENT OF REGENERATIVE TECHNOLOGIES. CURRENT KNOWLEDGE OF PLATELET RICH PLASMA AND THE POSSIBILITY OF ITS APPLICATION IN TREATMENT OF COMPLICATED UROLOGICAL DESEASES
https://doi.org/10.25207/1608-6228-2018-25-3-155-161
Abstract
Currently, the most actual problem in daily work of a surgeon is to get satisfactory results of the surgery, and to decrease the quantity of different complications, such as: recurrence of diseases, inflammatory and infection damage of operating wounds.
The most difficult for surgery treatment are urological diseases associated with the decrease of tissue vascularization, which leads to common fibrosis and the prevalence of soft tissue scarring, consequences of the radiation therapy.
Impaired wound healing is usually associated with lack of adequate blood supply, decrease of regenerative properties, increase of pro-inflammatory mechanisms. Platelet rich plasma is able to produce a lot of different growth factors, which stimulate neoangiogenesis, cytokines and сhemokines secretion, initialization of inflammatory cascade. These features lead to activation of regenerative mechanisms and growth of new blood vessels. In the present time, several forms of platelet rich plasma with different biological activity have been studied. The methods of its preparation and activation have been described. In this work the modern information of platelet rich plasma will be described in details.
About the Authors
V. L. MEDVEDEV
Federal State Budgetary Educational Institution of Higher Education ‘Kuban State Medical University’ of the Ministry of Healthcare of the Russian Federation;
Federal State Budgetary Educational Institution of Higher Education ‘Rostov State Medical University’ of the Ministry of Healthcare of the Russian Federation, Department of Urology;
State Budgetary Healthcare Institution ‘Research Institute, Regional Clinic Hospital №1’, Department of Urology
Russian Federation
Russian Federation
Sedina str., 4, Krasnodar, Russia, 350063;
Nahichevanskiy str., 29, Rostov-on-Don, Russia, 344022;
1 Maya str., 167, Krasnodar, Russia, 350086.
A. M. OPOLSKIY
Federal State Budgetary Educational Institution of Higher Education ‘Rostov State Medical University’ of the Ministry of Healthcare of the Russian Federation, Department of Urology;
State Budgetary Healthcare Institution ‘Research Institute, Regional Clinic Hospital №1’, Department of Urology
Russian Federation
Russian Federation
Nahichevanskiy str., 29, Rostov-on-Don, Russia, 344022;
1 Maya str., 167, Krasnodar, Russia, 350086.
M. I. KOGAN
Federal State Budgetary Educational Institution of Higher Education ‘Rostov State Medical University’ of the Ministry of Healthcare of the Russian Federation, Department of Urology;
Russian Federation
Nahichevanskiy str., 29, Rostov-on-Don, Russia, 344022
Russian Federation
Nahichevanskiy str., 29, Rostov-on-Don, Russia, 344022
References
1. Marx R.E., Carlson E.R., Eichstaedt R. et al: Platelet rich plasma: Growth factor enhancementfor bone grafts. Oral Surg.1998, 85:638,
2. Whitman D.H., Berry R.L., Green D.M. Platelet gel: an autologus alternative to fibrin glue with applications in oral and maxillofacialsurgery. J Oral Maxillofac Surg. 1997; 55: 1294-9.
3. Marx R.E. The biology of platelet-rich plasma. J Oral Maxillofac Surg. 2001; 59: 1120.
4. Haynesworth S.E., Kadiyala S., Liang L.N. et al: Platelet rich plasma stimulates stem cell chemotaxis, proliferation and potentiates osteogenic differentiation. The Spine Journal. 2002; 2(5): 68. DOI: 10.1016/s1529-9430(02)00313-3
5. Weibrich G., Hansen T., Kleis W., Buch R., Hitzler W.E., Effect of platelet concentration in platelet-rich plasma on peri-implant bone regeneration, Bone, 2004; 34: 665-671. DOI:10.1016/j.bone.2003.12.010
6. Behera P., Patel S., Shetty V. Orthobiologics and platelet rich plasma. Indian J Orthop. 2014 Jan; 48(1): 1-9. DOI:10.4103/0019-5413.125477
7. Xuetao X., Changqing Z., Rocky S Tuan., Biology of platelet-rich plasma and its clinical application in cartilage repair. Arthritis Res Ther. 2014; 16(1): 204. DOI:10.1186/ar4493
8. Anitua E., Sánchez M., Orive G., Andía I. The potential impact of the preparation rich in growth factors (PRGF) in different medical fields. Biomaterials. 2007 Nov; 28(31): 4551-60. DOI:10.1016/j.biomaterials.2007.06.037
9. Mishra A., Harmon K., Woodall J. et.al. Sports Medicine Applications of Platelet Rich Plasma. Current Pharmaceutical Biotechnology, 2012 Jun; 13(7): 1185-95. DOI:10.2174/138920112800624283
10. Moojen D.J., Everts P.A., Schure R.M. et al. Antimicrobial activity of platelet-leukocyte gel against Staphylococcus aureus. J Orthop Res. 2008 Mar; 26(3): 404-10. DOI:10.1002/jor.20519
11. Amable P.R., Vieira Carias R.B., Telles Teixeira M.V. et al. Platelet-rich plasma preparation for regenerative medicine: optimization and quantification of cytokines and growth factors, Stem Cell Res Ther. 2013, 4(3): 67. DOI:10.1186/scrt218
12. Antoniades H.N., Galanopoulos T., Neville-Golden J., Kiritsy C.P., Lynch S.E. Expression of growth factor and receptor mRNA in skin epithelial cells following acute cutaneous injury. Am. J. Pathol. 1993; 142: 1099-110.
13. Galliera E., Corsi M.M., Banfi G. Platelet rich plasma therapy: inflammatory molecules involved in tissue healing. J. Biol Regul Homeost Agents. 2012 Apr-Jun; 26(2 Suppl.1): 35S-42S.
14. Marx R.E. Platelet-rich plasma (PRP): what is PRP and what is not PRP? Implant Dent. 2001; 10: 225-228. DOI:10.1097/00008505-200110000-00002
15. Padulo J., Oliva F., Frizziero A., Maffulli N. Basic principles and recommendations in clinical and field science research. Muscle, ligaments and tendons Journal. 2013; 4: 250-252. DOI:10.11138/mltj/2016.6.1.001
16. Hsu W.K, Mishra A., Rodeo S.R., Fu F., Terry M.A., Randelli P. et al., Platelet-rich plasma in orthopaedic applications: evidence-based recommendations for treatment. J. Am. Acad. Orthop. Surg. 2013; 21: 739-748. DOI:10.5435/00124635-201312000-00004
17. Eppley B.L., Pietrzak W.S., Blanton M. Platelet-rich plasma: a review of biology and applications in plastic surgery. Plast Reconstr Surg. 2006 Nov; 118(6): 147-159. DOI: 10.1097/01.prs.0000239606.92676.cf
18. Marx R.E., Platelet-Rich Plasma: Evidence to Support. J Oral Maxillofac Surg. 2004; 62: 489-496. DOI: 10.1016/j.joms.2004.05.205
19. David M. EhrenfestD., Andia I., Matthias A. Zumstein Classification of platelet concentrates (Platelet-Rich Plasma-PRP, Platelet-Rich Fibrin-PRF) for topical and infiltrative use in orthopedic and sports medicine: current consensus, clinical implications and perspectives. Muscles Ligaments Tendons J. 2014 Jan-Mar; 4(1): 3-9. DOI: 10.11138/mltj/2014.4.1.0013
20. Jeffrey M. DeLong, Russell R.P., Mazzocca A.D. PlateletRich Plasma: The PAW Classification System. The Journal of Arthroscopic & Related Surgery. 2012; 287: 998-1009. DOI: 10.1016/j.arthro.2012.04.148
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For citations:
MEDVEDEV V.L., OPOLSKIY A.M., KOGAN M.I. PROSPECTS FOR THE DEVELOPMENT OF REGENERATIVE TECHNOLOGIES. CURRENT KNOWLEDGE OF PLATELET RICH PLASMA AND THE POSSIBILITY OF ITS APPLICATION IN TREATMENT OF COMPLICATED UROLOGICAL DESEASES. Kuban Scientific Medical Bulletin. 2018;25(3):155-161. (In Russ.) https://doi.org/10.25207/1608-6228-2018-25-3-155-161
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