Effects of cytoflavin on biochemical indicators in patients with maxillofacial area phlegmons
https://doi.org/10.25207/1608-6228-2020-27-1-18-26
Abstract
Aim. To assess the effect of cytoflavin on the dynamics of the blood and oral fluid prooxidant-antioxidant system in patients with maxillofacial area phlegmons.
Materials and methods. 55 patients were included in the study. The patients were divided into three groups: control group (group 1, n = 20); comparison group (group 2, n = 15); patients with phlegmons of the maxillofacial area (group 3, n = 20). As part of therapy, the patients in group 3 were additionally receiving cytoflavin (10 ml cytoflavin in 200 ml saline solution, 1 time per day, for 6 days). The treatment and monitoring was performed over the period of 6 days, during which the blood and oral fluid indicators were estimated 4 times (day 1, 2, 4 and 6).
Results. Cytoflavin had a positive effect on the state of the prooxidant-antioxidant balance in patients with maxillofacial area phlegmons. In comparison with the control group, patients in group 3 demonstrated a lower content of oxidative modifi cation products and a higher antioxidant activity of blood plasma. Cytoflavin therapy also led to an increase in the activity of glutathione peroxidase and reductase, as well as an increase in the concentration of glutathione at the last stage of the therapy.
Conclusion. The obtained data indicate the potential of cytoflavin as part of complex metabolic therapy for patients with purulent inflammatory processes of the maxillofacial area.
About the Authors
Tatiana V. Gaivoronskaya
Kuban State Medical University
Russian Federation
Russian Federation
Dr. Sci. (Med.), Head of the Department of Surgical Dentistry and Maxillofacial Surgery,
Rashpilevskaya str., d. 31, Krasnodar, 350000;
Mitrofanа Sedina str., 4, Krasnodar, 350063
Oksana V. Shvets
Kuban State Medical University
Russian Federation
Russian Federation
Graduate Student, Department of Department of Surgical Dentistry and Maxillofacial Surgery,
Mitrofanа Sedina str., 4, Krasnodar, 350063
Svetlana K. Shafranova
Kuban State Medical University
Russian Federation
Russian Federation
Cand. Sci. (Med.), Ass. Prof., Department of Department of Surgical Dentistry and Maxillofacial Surgery,
Mitrofanа Sedina str., 4, Krasnodar, 350063
References
1. Durnovo E.A., Vysel’tseva Yu.V., Mishina N.V., Khomutinnikova N.E., Marochkina M.S. Peculiarities of clinico-immunological diagnostics of common inflammatory disease of the soft tissues in the maxillofacial region and their complications. Rossiiskii Stomatologicheskii Zhurnal. 2012; 3: 22–26 (In Russ., English abstract).
2. I 2. Durnovo E.A., Vysel’tseva Yu.V., Mishina N.V., Khomutinnikova N.E., Oleneva Yu.V., Katkova Yu.O., et al. Clinical immunological peculiarities of complicated course of odontogenic phlegmons of maxillofacial region. Stomatologiya. 2010; 89(2): 29–31 (In Russ., English abstract).
3. Kazaryan A.S., Gaivoronskaya T.V., Nedel’ko N.A. Dynamics of intensity of reactions free radicalis of oxidation at treatment sick odontogenis phlegmons of maxillofacial area with use antihipoxant and antioxidant therapies. Kubanskii Nauchnyi Meditsinskii Vestnik. 2008; 5(104): 71–74 (In Russ., English abstract).
4. Sipkin A.M., Davydov I.A., Akhtyamov D.V., Blagikh O.E. Odontogenic purulent-inflammatory diseases of maxillofacial area: modern view on treatment and rehabilitation. Klinicheskaya Stomatologiya. 2018; 2(86): 66–69 (In Russ., English abstract).
5. Olifirova О.S., Kozka A.A. Antioxidants in complex treatment of purulent-necrotic wounds. Dal’nevostochnyi Meditsinskii Zhurnal. 2015; 2: 21–23 (In Russ., English abstract).
6. Galimov O.V., Tuĭsin S.R. Application of combined bandaging material with antioxidant activity for suppurative diseases of soft tissues. Khirurgiya. Zhurnal imeni N.I. Pirogova. 2010; (3): 41–44 (In Russ., English abstract).
7. Kabanova А.А., Pohodenko-Chudakova I.О. Antioxidants in complex treatment of pyoinflammatory diseases in maxillofacial area. Problemy Zdorov’ya i Ekologii. 2010; 1: 27–31 (In Russ., English abstract).
8. Sipkin A.M., Blagikh O.E., Davidov I.A., Ahtyamov D.V., Chursinova Yu.V. Topical application of mitochondrial antioxidants in the complex treatment of patients with odontogenic purulent inflammation of the maxillofacial region. Clinical cases. Klinicheskaya Stomatologiya. 2019; 89(1): 71–75 (In Russ., English abstract).
9. Shafranova S.K., Gaivoronskaya T.V., Kazaryan A.S., Paramonova O.A. Dynamics of morphological characteristics of the wound process in patients with odontogenic fl egmons in antioxidant therapy. Kuban Scientifi c Medical Bulletin. 2018; 25(5): 111–115 (In Russ., English abstract). DOI: 10.25207/1608-6228-2018-25- 5-111-115
10. Markevich P.S., Danilenko S.J., Yankin A.V. The priority directions of use of Cytoflavin. Acta Biomedica Scientifi ca. 2010; 73(3): 109–113 (In Russ., English abstract).
11. Ilchenko L.Yu., Okovity S.B. Remaxol: mechanisms of action and application in real clinical practice. Part I. Arhiv Vnutrennej Mediciny. 2016; 6(2): 16–21 (In Russ., English abstract).
12. Valeev V.V., Kovalenko A.L., Talikova E.V., Zaplutanov V.A., Delvig-Kamenskaya T.Yu. Biological Functions of Succinate (a Review of Foreign Experimental Studies). Antibiotiki i Khimioterapiya. 2015; 60(9–10): 33–37 (In Russ., English abstract).
13. Pell V.R., Chouchani E.T., Frezza C., Murphy M.P., Krieg T. Succinate metabolism: a new therapeutic target for myocardial reperfusion injury. Cardiovasc. Res. 2016; 111(2): 134–141. DOI: 10.1093/cvr/cvw100
14. Tang X.L., Liu J.X., Li P., Dong W., Li L., Zheng Y.Q., et al. Protective effect of succinic acid on primary cardiomyocyte hypoxia/reoxygenation injury. Zhongguo Zhong Yao Za Zhi. 2013; 38(21): 3742–3746.
15. Bykov I.M., Popov K.A., Egorova I.A., Storozhuk A.P. Assessment of indicators of the thiol metabolism of blood plasma of patients with inflammatory diseases of the small pelvis organs at antioxidant correction. Medical News of the North Caucasus. 2018; 13(2): 402–406. DOI: 10.14300/mnnc.2018.13062
16. Bykov I.M., Basov A.A., Malyshko V.V., Dzhimak S.S., Fedosov S.R., Moiseev A.V. Dynamics of the pro-oxidant/antioxidant system parameters in wound discharge and plasma in experimental purulent wound during its technological liquid phase treatment. Bulletin of Experimental Biology and Medicine. 2017; 163(2): 237–241 (In Russ., English abstract).
17. Bykov I.M., Popov K.A., Tsymbalyuk I.Yu., Dzhimak S.S., Shashkov D.I., Malyshko V.V., et al. The metabolic correction of the experimental alloxan diabetes by means of the antioxidant remedies. Voprosy Pitaniya. 2017; 86(3): 68–76 (In Russ., English abstract).
18. Popov K.A., Bykov I.M., Tsymbalyuk I.Yu., Bykov M.I., Sidorenko A.N., Storozhuk P.G., et al. Changes in state of the thiol linkages of an antioxidant system during ischemia and reperfusion, against a background of vascular exclusion in the rat liver. Medical News of the North Caucasus. 2018; 13(3): 525– 529. DOI: 10.14300/mnnc.2018.13095
Review
For citations:
Gaivoronskaya T.V., Shvets O.V., Shafranova S.K. Effects of cytoflavin on biochemical indicators in patients with maxillofacial area phlegmons. Kuban Scientific Medical Bulletin. 2020;27(1):18-26. (In Russ.) https://doi.org/10.25207/1608-6228-2020-27-1-18-26
Views:
522
Email this article 