Preterm labour: an open problem in XXI century
https://doi.org/10.25207/1608-6228-2020-27-4-27-37
Abstract
Preterm labour (PL) is a relevant problem in maternal and child healthcare displaying a persistent trend. The risk of death is 25–35 times higher in premature infants than in normal children, whilst PL-associated stillbirth is 8–13 times more frequent over term labours. Severity of complications with prematurity is inversely proportional to the term of gestation. In general, PLs account for up to 70% of perinatal mortality. At the last FIGO Congress in 2018, PL was identified as an unsolved problem with no current treatment. Lack of scientific grounds for the PL aetiology and pathogenesis precludes practical success alike in prevention and treatment of this complication of pregnancy. In the bottom line, the past 60 years have not witnessed a global decline in the PL rate, it reaches to 9.5% of total births (with a slight variation depending on national commonwealth), and 15m premature infants are born annually. Two challenges currently face improvement of the PL perinatal outcomes: understanding the mechanism of PL and developing a strategy to render support at each stage of medical care to postpone, prevent the distress syndrome and sustain the foetus. The article tackles major issues in the diagnosis, treatment and prevention of preterm labour, aside with its impact on neonatal morbidity and mortality.
About the Authors
V. E. Radzinsky
RUDN University
Russian Federation
Russian Federation
Viktor E. Radzinsky — Honoured Worker of Science of the Russian Federation, Corresponding Member of the Russian Academy of Sciences, Dr. Sci. (Med.), Prof., Head of the Department of Obstetrics and Gynaecology with perinatology training
Miklukho-Maklaya str., 6, Moscow, 117198
A. A. Orazmuradov
RUDN University
Russian Federation
Russian Federation
Agamurad A. Orazmuradov — Dr. Sci. (Med.), Prof., Department of Obstetrics and Gynaecology with perinatology training
Miklukho-Maklaya str., 6, Moscow, 117198
tel.: +7 (903) 164-54-34
I. V. Savenkova
RUDN University
Russian Federation
Russian Federation
Irina V. Savenkova — Postgraduate Student, Department of Obstetrics and Gynaecology with perinatology training
Miklukho-Maklaya str., 6, Moscow, 117198
K. F. Damirova
RUDN University
Russian Federation
Russian Federation
Kemer F. Damirova — Postgraduate Student, Department of Obstetrics and Gynaecology with perinatology training
Miklukho-Maklaya str., 6, Moscow, 117198
H. Haddad
RUDN University
Russian Federation
Russian Federation
Halid Haddad — Clinical Resident, Department of Obstetrics and Gynaecology with perinatology training
Miklukho-Maklaya str., 6, Moscow, 117198
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Review
For citations:
Radzinsky V.E., Orazmuradov A.A., Savenkova I.V., Damirova K.F., Haddad H. Preterm labour: an open problem in XXI century. Kuban Scientific Medical Bulletin. 2020;27(4):27-37. (In Russ.) https://doi.org/10.25207/1608-6228-2020-27-4-27-37
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