The activity of NADPH-oxidase of neutrophilic leukocytes in patients with chronic generalized periodontitis in aggregate with iron - deficiency anemia
Abstract
In patients with chronic generalized periodontitis in aggregate with iron-deficiency anemia revealed dysfunction of neutrophilic leukocytes caused by decreased activity of iron-containing components of antibacterial systems, in particular of NADPH-oxidase. Dental treatment of these patients is ineffective without the use of iron preparations.
About the Authors
I. A. Slavinsky
Kuban state medical university
Russian Federation
Russian Federation
L. A. Skorikova
Kuban state medical university
Russian Federation
Russian Federation
O. V. Tsymbalov
Kuban state medical university
Russian Federation
Russian Federation
References
1. Герасимов И.Г. Неоднородность нейтрофилов в фагоцитозе и респираторном взрыве // Клин. лаб. диагностика. -2004. - № 6. - С. 34-36.
2. Грудянов А.И. Заболевания пародонта. - М.: МИА, 2009. - 336 с.
3. Сапрыкин В.П., Кузнецов С.Л. Морфологические варианты нейтрофильных гранулоцитов крови практически здоровых людей // Морфология. - 2001. - Т. 120. № 6. - С. 37-41.
4. Ambruso D.R., Cusack N., Thurman G. NADPH oxidase activity of neutrophil specific granules: requirements for cytosolic components and evidence of assembly during cell activation // Mol. genet. metab. - 2004. - V. 81. № 4. - P. 313-321.
5. Freudenstein-Dan A., Gold D., Fishelson Z. Killing of schistosomes by elastase and hydrogen peroxide: implications for leukocyte-mediated schistosome killing // J. parasitol. - 2003. -V. 89. № 6. - P. 1129-1135.
6. Mueller H.P. Periodontology. - 2004. - P. 256.
7. Rosen H., Crowley J.R., Heinecke J.W. Human neutrophils use the myeloperoxidase-hydrogen peroxide-chloride system to chlorinate but not nitrate bacterial proteins during phagocytosis // J. biol. chem. - 2002. - V. 277. № 34. - P. 463-468.
Review
For citations:
Slavinsky I.A., Skorikova L.A., Tsymbalov O.V. The activity of NADPH-oxidase of neutrophilic leukocytes in patients with chronic generalized periodontitis in aggregate with iron - deficiency anemia. Kuban Scientific Medical Bulletin. 2015;(1):111-114. (In Russ.)
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