Experimental substantiation of an opportunity of the use of vardenafil for pharmacological preconditioning in surgery
Abstract
The possibility of vardenafil using for pharmacological preconditioning in surgery is studied. Experiment was carried out on Wistar rats. The influence of vardenafil on the survival of pedicled isolated skin flap and the state of the microvasculature in the ischemic skeletal muscle was defined in comparison with the effect of distant ischemic preconditioning. It was revealed that vardenafil improves survival of pedicled isolated skin flap and stimulates angiogenesis in the ischemic leg muscles of rat.
About the Authors
I. M. Kolesnik
FPE Kursk state medical university
Russian Federation
Russian Federation
M. V. Pokrovskiy
Belgorod state national research university
Russian Federation
Russian Federation
V. A. Lasarenko
FPE Kursk state medical university
Russian Federation
Russian Federation
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Review
For citations:
Kolesnik I.M., Pokrovskiy M.V., Lasarenko V.A. Experimental substantiation of an opportunity of the use of vardenafil for pharmacological preconditioning in surgery. Kuban Scientific Medical Bulletin. 2015;(2):77-81. (In Russ.)
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