The level of VEGF-A in the lacrimal fluid of diabetic retinopathy
Abstract
The lacrimal fluid was investigated in 56 people (95 eyes) with type II diabetes, of which 11 (11 eyes) with no signs of diabetic retinopathy and 45 patients (84 eyes) suffering from diabetic retinopathy of varying severity. Investigation of VEGF-A (vascular endothelial growth factor A) in stimulated lacrimal fluid revealed its level in all patients. It was significantly higher in patients with diabetic retinopathy compared with data that have been obtained in patients with diabetes, but without signs of diabetic retinopathy. Statistically significant differences in the level of VEGF-A in patients with non-proliferative and proliferative retinopathy of 1-3 stages have not been identified. At the same time in patients with far-advanced retinopathy with marked variations of fatal retina and vitreous body (detachment expressed gliosis), but without evidence of neovascularization of the anterior eye, a significant decrease in the level of vasoproliferative factors has revealed.
About the Authors
Yu. A. Borzilova
SBEI HPE «Northwest state medical university named after I.I. Mechnikov» of Ministry of health of Russian Federation
Russian Federation
Russian Federation
L. A. Boldyreva
«The Rostov state medical university» of Ministry of health of Russian Federation
Russian Federation
Russian Federation
I. V. Shlyk
«The Rostov state medical university» of Ministry of health of Russian Federation
Russian Federation
Russian Federation
I. P. Shurygina
«The Rostov state medical university» of Ministry of health of Russian Federation
Russian Federation
Russian Federation
M. V. Gatcu
St. Petersburg branch of FSBI «IRTC» Eye Microsurgery» named after academician S.N. Fyodorov» of he Ministry of Health of Russian Federation
Russian Federation
Russian Federation
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Review
For citations:
Borzilova Yu.A., Boldyreva L.A., Shlyk I.V., Shurygina I.P., Gatcu M.V. The level of VEGF-A in the lacrimal fluid of diabetic retinopathy. Kuban Scientific Medical Bulletin. 2015;(6):16-18. (In Russ.)
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