Changes in expression of estrogen-regulatory genes in malignancy uterine tissues
Abstract
We investigated the relative expression of genes responsible for the estrogen reception and metabolism - CYP1A 1, CYP1A 2, CYP1B 1, CYP19A, ESR1, ESR2, GPER, STS, SULT1A and SULT1E1 - by real-time PCR in tumor and conditionally healthy uterine tissues of 27 female patients in Southern Russia aged 38-72 years with histologically confirmed diagnosis of uterine cancer. It is found that transcription activity of these genes during malignancy of uterine tissues depends of female patients age and the stage of tumor cells differentiation. It is potentially allow to use investigated genes as biomarkers of uterine tissues malignancy with considering age features of female patients and stages of cancer process development.
About the Authors
O. I. Kit
federal state budgetary institution «Rostov cancer research institute» the Ministry of health of the Russian Federation
Russian Federation
Russian Federation
D. I. Vodolazhsky
federal state budgetary institution «Rostov cancer research institute» the Ministry of health of the Russian Federation
Russian Federation
Russian Federation
D. S. Kutilin
federal state budgetary institution «Rostov cancer research institute» the Ministry of health of the Russian Federation
Russian Federation
Russian Federation
T. I. Moiseenko
federal state budgetary institution «Rostov cancer research institute» the Ministry of health of the Russian Federation
Russian Federation
Russian Federation
I. S. Nikitin
federal state budgetary institution «Rostov cancer research institute» the Ministry of health of the Russian Federation
Russian Federation
Russian Federation
E. M. Frantsiyants
federal state budgetary institution «Rostov cancer research institute» the Ministry of health of the Russian Federation
Russian Federation
Russian Federation
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Review
For citations:
Kit O.I., Vodolazhsky D.I., Kutilin D.S., Moiseenko T.I., Nikitin I.S., Frantsiyants E.M. Changes in expression of estrogen-regulatory genes in malignancy uterine tissues. Kuban Scientific Medical Bulletin. 2016;(2):84-90. (In Russ.)
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