Immune response features in children with chronic constipation
Abstract
In the article the results of examination of some immune characteristics, including some autoantibodies in 28 children with chronic constipation are represented. Increased levels of circulating immune complexes and increased spontaneous NST test were the most common immune laboratory findings. ANCA were found in 18 patients. There were no correlation between the type of constipation (dolichosigmoid, anal athresia, functional constipation), severety and character of disbiosis and ANCA rates. Thus, in most cases revealed immune disorders may indicate chronic inflammation in the bowl associated with chronic constipation. Children with increased ANCA rates seems have the higher risk of autoimmune disorders in future
Keywords
хронический запор,
иммунитет,
аутоантитела,
дети,
chronic constipation,
immunity,
autoantibodies,
children
About the Authors
O. V. Moskalets
Moscow regional research and clinical Institute (MONIKI)
Russian Federation
Russian Federation
V. I. Scherbina
Moscow regional research and clinical Institute (MONIKI)
Russian Federation
Russian Federation
References
1. Баранов А. А., Щербаков П. Л. Актуальные вопросы детской гастроэнтерологии // Вопросы современной педиатрии. - 2002. - Т. 1. № 1. - С. 12-16.
2. Гриневич В. Б., Захарченко М. М. Современные представления о значении кишечного микробиоценоза человека и способы коррекции его нарушений // Новые Санкт-Петербургские врач. ведомости. - 2003. - № 3. - С. 13-20.
3. Киргизов И. В., Ленюшкин А. И., Дударев В. А. Состояние системы гемостаза и иммунитета у детей с хроническим толстокишечным стазом // Детская хирургия. - 2005. - № 5. -С. 30-34.
4. Машков А. Е., Русанова Е. В., Филюшкин Ю. Н., Щербина В. И., Слесарев В. В. Дисбактериоз и его коррекция при хроническом толстокишечном стазе у детей с долихосигмой // Детская хирургия. - 2014. - № 2. - С. 7-10.
5. Цимбалова Е. Г., Потапов А. С., Баранов К. Н. Хронические запоры у детей // Вопросы соврем. педиатрии. - 2002. - № 1 (6). - С. 56.
6. Lembo A., Camilleri M. Chronic constipation // New. engl. j. med. - 2003. - V. 349. - P. 1360-1368.
7. Lunniss P. J., Gladman M. A., Benninga M. A., Rao S. S. Pathophysiology of rectal evacuatory function // Neurogastroenterol. motil. - 2009. - V. 21 (s2). - P. 31-44.
8. Schultz H. From infection to autoimmunity: a new model for induction of ANCA against the bactericidal/permeability increasing protein (BPI) // Autoimmun. rev. - 2000 - V. 6 (4). -P. 223-227.
9. Tariq S. H. Constipation in Long-term care // J. am. med. dir. assotc. - 2007. - V. 8. - P. 209-218.
10. Woodward M. N., Foley P., Cusick E. L. Colostomy for treatment of functional constiopation in children: a preliminary report // J. pediatr. gastroenterol. nutr. - 2004. - № 38. -P. 75-78.
Review
For citations:
Moskalets O.V., Scherbina V.I. Immune response features in children with chronic constipation. Kuban Scientific Medical Bulletin. 2016;(2):119-121. (In Russ.)
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