COMPARATIVE ANALYSIS IMMUNOTROPIC EFFECTS IN VITRO DERINAT AND SYNTHETIC TLR9 AGONIST ON RECEPTOR FUNCTION OF NEUTROPHILIC GRANULOCYTES AND MONOCYTES IN NORMAL AND INFECTIOUS PROCESS
Abstract
Comparative evaluation of character of the expression of TLR9 and CD11b receptors by neutrophilic granulocytes and monocytes whole blood under the influence of Derinat and synthetic TLR9 ligand in healthy individuals and in acute infectious diseases of viral and bacterial origin has been studied. It has been shown that the unidirectional effects of study drugs relate changes in the number of neutrophils, carrying TLR9, and MFI CD289 in all groups, and monocytes only in groups with infectious process. Differently directed effects identified in relation to expression of molecules CD11b monocytes in all groups, and neutrophils in a group of healthy controls.
About the Authors
T. V. Rusinova
ФГБОУ ВО «Кубанский государственный медицинский университет» МЗ РФ
Russian Federation
Russian Federation
G. A. Chudilova
ФГБОУ ВО «Кубанский государственный медицинский университет» МЗ РФ
Russian Federation
Russian Federation
N. V. Kolesnikova
ФГБОУ ВО «Кубанский государственный медицинский университет» МЗ РФ
Russian Federation
Russian Federation
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Review
For citations:
Rusinova T.V., Chudilova G.A., Kolesnikova N.V. COMPARATIVE ANALYSIS IMMUNOTROPIC EFFECTS IN VITRO DERINAT AND SYNTHETIC TLR9 AGONIST ON RECEPTOR FUNCTION OF NEUTROPHILIC GRANULOCYTES AND MONOCYTES IN NORMAL AND INFECTIOUS PROCESS. Kuban Scientific Medical Bulletin. 2016;(5):94-97. (In Russ.)
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