CURRENT UNDERSTANDING OF THE ROLE OF EPITHELIAL-MESENCHYMAL TRANSITION IN THE PROGRESSION OF CHRONIC KIDNEY DISEASE
Abstract
This article provides an overview of the currently acquired information concerning the phenomenon of epithelialmesenchymal transition and its role in the formation of interstitial kidney fibrosis and the mechanisms of its development and possible points of application to produce a therapeutic effect. Particularly interesting in this respect was the transforming growth factor-ß apparently plays a key role in induction of epithelial-mesenchymal transition.
About the Authors
V. E. Potapov
Rostov State Medical University
Russian Federation
Russian Federation
E. A. Sinelnik
Rostov State Medical University
Russian Federation
Russian Federation
M. A. Akimenko
Rostov State Medical University
Russian Federation
Russian Federation
D. G. Pasechnik
Rostov State Medical University
Russian Federation
Russian Federation
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Review
For citations:
Potapov V.E., Sinelnik E.A., Akimenko M.A., Pasechnik D.G. CURRENT UNDERSTANDING OF THE ROLE OF EPITHELIAL-MESENCHYMAL TRANSITION IN THE PROGRESSION OF CHRONIC KIDNEY DISEASE. Kuban Scientific Medical Bulletin. 2016;(6):104-109. (In Russ.)
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