PREVALENCE OF POLYMORPHIC VARIANTS OF GENES HLA SYSTEM IN HEALTHY DONORS OF KRASNODAR REGION
https://doi.org/10.25207/1608-6228-2014-7-129-132
Abstract
Polymorphism studies major histocompatibility complex human (HLA-system) in the world, held from mid-60s, when serotyping methods revealed that in different populations are determined by different sets of options HLA-antigens. Genes of class II HLA-system determines a significant portion of the genetic predisposition to the development of the majority of diseases associated with the immune system. In the analysis of allelic polymorphism of the genes HLA-DQA1, HLA-DRB1, HLA-DRB1 found that among healthy donors Krasnodar in absolute terms more common alleles DQA1*0501, DQA1* 0201, DQB1* 0301, DQB1* 0601/8, DRB1 *01 DRB1* 15. Compare the population do not have significant differences and can be used as control groups in studies aimed at understanding the contribution of genes HLA II class for the development of diseases in the russian group. The results indicate the presence in the population of the Krasnodar territory is not only the «classical» alleles, but found only in Russia and in the region.
About the Authors
A. I. Tlif
GboU VPo KubGMU Minsravsocravitiya Rossii; Children’s regional clinic
Russian Federation
Russian Federation
350063, Krasnodar, Sedina, str., 4; 350007, Krasnodar, ploshehad Pobegy, 1
E. I. Kondratyeva
GboU VPo KubGMU Minsravsocravitiya Rossii
Russian Federation
Russian Federation
350063, Krasnodar, Sedina, str., 4
N. V. Tarasenko
NII medical genetics RAMN
Russian Federation
Russian Federation
634050 Tomsk, str. Ushayki naberegnaya, 10
М. Ya. Zobenko
GboU VPo KubGMU Minsravsocravitiya Rossii
Russian Federation
Russian Federation
350063, Krasnodar, Sedina, str., 4
A. A. T. Kodenev
GbUZ «blood transfusion station» of the Ministry of health of the Krasnodar territory
Russian Federation
Russian Federation
350040, Krasnodar, str. Dimitrova, 166
L. R. Gysaryk
GboU VPo KubGMU Minsravsocravitiya Rossii
Russian Federation
Russian Federation
350063, Krasnodar, Sedina, str., 4
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Review
For citations:
Tlif A.I., Kondratyeva E.I., Tarasenko N.V., Zobenko М.Ya., Kodenev A.A., Gysaryk L.R. PREVALENCE OF POLYMORPHIC VARIANTS OF GENES HLA SYSTEM IN HEALTHY DONORS OF KRASNODAR REGION. Kuban Scientific Medical Bulletin. 2014;(7):129-132. (In Russ.) https://doi.org/10.25207/1608-6228-2014-7-129-132
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