COMPARATIVE EFFECTIVENESS OF TWO SCHEDULES OF GYNESTRIL ADMINISTRATION IN TREATMENT OF UTERINE FIBROIDS
https://doi.org/10.25207/1608-6228-2017-24-4-115-121
Abstract
Modern options of uterine fibroids pharmacotherapy allow for individual selection of therapy.
Aim. To compare the effectiveness of uterine fibroids treatment with administration of mifepristone (Gynestril) on the basis of a differentiated approach to the assignment of two treatment schedules in various dosages: 25 mg or 50 mg per day for three months.
Materials and methods. A prospective comparative study was conducted at the clinical bases of Department of Obstetrics and Gynecology with the Course of Perinatology of the Peoples’ Friendship University of Russia (Moscow) and the Department of Obstetrics, Gynecology and Perinatology of the Kuban State Medical University (Krasnodar). 160 women with uterine myoma were enrolled in the clinical groups. Randomization was carried out by a double-blind method using envelopes.
Results. Administration of mifepristone (Gynestril) at a dosage of 50 mg per day for 12 weeks and 25 mg per day for 24 weeks has comparable efficacy.
Conclusion. Due to the assessment of subjective and objective criteria of drug tolerance, an individual dose selection of mifepristone is possible without compromising the achievement of the therapeutic effect.
About the Authors
V. E. Radzinsky
Peoples’ Friendship University of Russia
Russian Federation
Russian Federation
Department of Obstetrics and Gynecology with the Course of Perinatology
117198, Moscow, Miklukho-Maklaya str., 8
I. M. Ordiyants
Peoples’ Friendship University of Russia
Russian Federation
Russian Federation
Department of Obstetrics and Gynecology with the Course of Perinatology
117198, Moscow, Miklukho-Maklaya str., 8
V. A. Khorolsky
Kuban State Medical University
Russian Federation
Russian Federation
Department of Obstetrics, Gynecology and Perinatology
Corresponding author: Vadim A. Khorolsky
350063, Krasnodar, Sedina str. 4; tel. +7(988)2486199
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Review
For citations:
Radzinsky V.E., Ordiyants I.M., Khorolsky V.A. COMPARATIVE EFFECTIVENESS OF TWO SCHEDULES OF GYNESTRIL ADMINISTRATION IN TREATMENT OF UTERINE FIBROIDS. Kuban Scientific Medical Bulletin. 2017;(4):115-121. (In Russ.) https://doi.org/10.25207/1608-6228-2017-24-4-115-121
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