CLINICAL AND IMMUNOLOGICAL CHANGES IN TREATMENT OF ADENOMYOSIS IN PATIENTS WITH INFERTILITY
https://doi.org/10.25207/1608-6228-2017-24-5-37-44
Abstract
Aim. The aim of this study was to asses changes of adhesion molecules (L-selectin, neopterin and interleukin-6) in patients with adenomyosis-related infertility during the therapy.
Materials and methods. 49 patients with infertility caused by adenomyosis were examined and divided into 3 clinical groups: 1 group – 26 patients (35,1%) and 2 group – 23 patients (31,1%) with adenomyosis-associated infertility; 3 group (control) – 25 patients (33,8%). Adhesion molecules detection was performed by enzyme immunoassay (EIA). Visual evaluation scale was used for estimating of clinical aspects of adenomyosis.
Results. The diagnostic utility of L-selectin for monitoring the adenomyosis therapy effectiveness was shown. The difference between L-selectin levels before and after treatment was statistically significant, the correlation coefficient (R) reached 0,584. The gestagens application is preferable due to reliable normalization of L-selectin levels and decrease in intensity of algomenorrhea (in the 1st group – 1,3 times less, than in 2nd group) and dyspareunia (in the 1st group – 2,2 times less, than in the 2nd group) on visual evaluation scale.
Conclusions. Adenomyosis not accompanied by a significant increase in the production of systematic inflammatory response markers (neopterin and IL-6), the increase of adhesion molecules (L-selectin) indicates the imbalance of endothelial-thrombocyte-leukocyte interaction.
About the Authors
L. Yu. KARAKHALIS
Federal State Budgetary Educational Institution of Higher Education Kuban State Medical University of the Ministry of Healthcare of the Russian Federation
Russian Federation
Russian Federation
Sedina str., 4, Krasnodar, Russia, 350063
tel.: +7 (861) 222-05-43; +7-988-244-40-44
A. R. JHIGALENKO
Federal State Budgetary Educational Institution of Higher Education Kuban State Medical University of the Ministry of Healthcare of the Russian Federation
Russian Federation
Sedina str., 4, Krasnodar, Russia, 350063
Russian Federation
Sedina str., 4, Krasnodar, Russia, 350063
G. A. PENJHOYAN
Federal State Budgetary Educational Institution of Higher Education Kuban State Medical University of the Ministry of Healthcare of the Russian Federation
Russian Federation
Sedina str., 4, Krasnodar, Russia, 350063
Russian Federation
Sedina str., 4, Krasnodar, Russia, 350063
N. V. KOLESNIKOVA
Federal State Budgetary Educational Institution of Higher Education Kuban State Medical University of the Ministry of Healthcare of the Russian Federation
Russian Federation
Sedina str., 4, Krasnodar, Russia, 350063
Russian Federation
Sedina str., 4, Krasnodar, Russia, 350063
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For citations:
KARAKHALIS L.Yu., JHIGALENKO A.R., PENJHOYAN G.A., KOLESNIKOVA N.V. CLINICAL AND IMMUNOLOGICAL CHANGES IN TREATMENT OF ADENOMYOSIS IN PATIENTS WITH INFERTILITY. Kuban Scientific Medical Bulletin. 2017;(5):37-44. (In Russ.) https://doi.org/10.25207/1608-6228-2017-24-5-37-44
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