DIMEPHOSPHON EFFECTS ON SKIN MICROHAEMODYNAMICS
https://doi.org/10.25207/1608-6228-2017-24-5-90-95
Abstract
Aim. To demonstrate basic mechanisms of dimephosphon operation on skin microhaemodynamics.
Materials and methods. The study of dimephosphon effect on blood microcirculation of skin in outbred male rats included registration of perfusion index, mean square deviation, variation coefficient; determination of the amplitude of blood flow oscillations in different frequency range (by laser doppler flowmetry method).
Results. Dimephosphon stimulates oscillatory and non-oscillatory skin microhaemodynamic indiсes indicating the increase of peripheral tissues perfusion and blood flow modulation in microvessels due to endothelium functional activity increase, peripheral resistance decrease, increase of blood flow to the nutritive microvessel channel and venous outflow improvement.
Conclusion. Vasoactive properties of dimephosphon are manifested in its ability to affect vascular and extravascular regulatory processes of blood microcirculation of skin. Microvessel endothelium and its metabolic activity associated with NO release are the most sensitive to dimephosphon effect. The ability to increase endothelium NO production is the basic mechanism of dimephosphon vasodilatory action.
About the Authors
E. N. CHUYAN
Crimean Federal University Named After V.I. Vernadsky
Russian Federation
Russian Federation
Acad. Vernadsky Av., 4, Simperopol, Republic of the Crimea, Russia, 295007
tel.: 8(978) 792-80-75
M. Y. RAVAYEVA
Crimean Federal University Named After V.I. Vernadsky
Russian Federation
Acad. Vernadsky Av., 4, Simperopol, Republic of the Crimea, Russia, 295007
Russian Federation
Acad. Vernadsky Av., 4, Simperopol, Republic of the Crimea, Russia, 295007
D. A. NEFEDOV
Krasnodar Branch of FSBI “ISTC “Eye Microsurgery” named after acad. S.N. Fedorov, Ministry of Health Care of Russia
Russian Federation
Krasnyh Partisan St., 6, Krasnodar, Russia, 350000
Russian Federation
Krasnyh Partisan St., 6, Krasnodar, Russia, 350000
A. V. ZELENSKAYA
Federal State Budgetary Educational Institution of Higher Education Kuban State Medical University of the Ministry of Healthcare of the Russian Federation
Russian Federation
Sedin St., 4, Krsnodar, Russia, 350063
Russian Federation
Sedin St., 4, Krsnodar, Russia, 350063
P. A. GALENKO-YAROSHEVSKY
Federal State Budgetary Educational Institution of Higher Education Kuban State Medical University of the Ministry of Healthcare of the Russian Federation
Russian Federation
Sedin St., 4, Krsnodar, Russia, 350063
Russian Federation
Sedin St., 4, Krsnodar, Russia, 350063
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Review
For citations:
CHUYAN E.N., RAVAYEVA M.Y., NEFEDOV D.A., ZELENSKAYA A.V., GALENKO-YAROSHEVSKY P.A. DIMEPHOSPHON EFFECTS ON SKIN MICROHAEMODYNAMICS. Kuban Scientific Medical Bulletin. 2017;(5):90-95. (In Russ.) https://doi.org/10.25207/1608-6228-2017-24-5-90-95
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