Cytokine profile in infants with megaureter complicated by pyelonephritis

Abstract

Cytokines is a new class of endogenous polypeptide mediators of intercellular interactions which regulate the immune system and affect the inflammatory reaction. The works devoted to the research of cytokine profile in children with various forms of megaurether, complicated by pyelonephritis, are not so common in the literature. We conducted research on definition of serumal levels сytokines at children of early age with a megaureter complicated by secondary pyelonephritis. All the patients were divided into 3 groups: I group - obstructive megaurether (n=8); II group - refluxing megaurether (n=12); III group - control, with no signs of urodynamics (n=15). We determined the serum levels of the following cytokines - the factor of swelling necrosis - alpha (TNF-α,) interleukin-6(IL-6), soluble receptor of the factor of swelling necrosis TNF-1 (CTNF-R1) and interleukin-8 (IL-8). The probable immunological basis in development of defeat of kidneys is defined at an obstructive megaureter.