COMPARABLE PHARMACODYNAMICS OF TRADITIONAL AND RECTAL APPLICATION OF THE AMLODIPINE IN PATIENTS WITH ARTERIAL HYPERTENSION WITH HIGH RISK OF CEREBROVASCULAR COMPLICATIONS
Abstract
Evaluation of the antihypertensive efficiency of 10 mg amlodipin rectal suppositories monotherapy of grade 2 arterial hypertension with brachiocephalic artery atherosclerosis in comparison with 10 mg amlodipin tablets during 4 weeks was carried out. It was established that amlodipin rectal suppositopies significant decrease systolic and diastolic arterial pressure and normalize its variability. Also linear rate asymmetry of carotid arterial blood flow essential decreases that indicates increase of brain perfusion. Rising of daily hypotensive activity uniformity after application of amlodipin rectal dosage form in comparison with tablet was determined. Side reactions and undesirable effects throughout amlodipin use for both dosage forms wasn't noted.
About the Authors
I. L. Kechin
Zaporozhye state medical university
Russian Federation
Russian Federation
AL ZEDAN Fadi
Zaporozhye state medical university; Zaporozhye state medical university
Russian Federation
Russian Federation
V. V. Gladyshev
Zaporozhye state medical university; Zaporozhye state medical university
Russian Federation
Russian Federation
S. I. Kechyn
Imperial college
Russian Federation
Russian Federation
References
1. Гладишев В. В. Виготовлення супозиторіїв з амлодипіном в умовах аптеки / В. В. Гладишев, Фаді Ал Зедан, І. Л. Кечин, C. І. Кечин // !нформ. лист МОЗ України. - 2012. - Вип. 6 по пробл. «Фармація». - № 187. - 4 с.
2. Фаді Ал Зедан. Розробка й біофармацевтичні дослідження супозиторіїв з амлодипіном / Ал Зедан Фаді, В. В. Гладишев, Б. С. Бурлака, І. Л. Кечин // Медична хімія. - 2011. - Т. 13. № 2 (47). - С. 72-75.
3. Фади Ал Зедан. Исследование гранулометрического состава амлодипина и его влияния на биофармацевтические свойства ректальних суппозиториев / Ал Зедан Фади, С. А. Гладышева, Б. С. Бурлака // Запорожский медицинский журнал. - 2011. -№ 6 (69). - С. 110-112.
4. Фади Ал Зедан. Изучение микробиологической чистоты ректальных суппозиториев с амлодипином / Ал Зедан Фади, Н. Л. Колычева, В. В. Гладышев // Сучасні досягнення фармацевтичної технології: Мат. III наук. - практ. конф. з міжн. участ. - Харків, 2012. - С. 181.
5. Ольбинская Л. И. Мониторирование артериального давления / Л. И. Ольбинская, А. И. Мартынов, Б. А. Ханаев. - М.: Медицина, 1998. - 99 с.
6. Asmi M. N. A practical guide to echocardiography / M. N. Asmi, M. J. Walsh. - London, 1995. - 258 p.
7. Combination therapy versus monotherapy in reducing blood pressure: meta-analysis on 11,000 participants from 42 trials / D. S. Wald, M. Law, J. K. Morris (et al.) // Amer. j. med. - 2009. -V. 122. № 5. - P. 290-300.
8. Guidelines for the Management of Arterial Hypertension / G. Mancia, G. de Baker, R. Givkova (et al.) // J. hypertension. - 2007. -V. 25. № 4. - P. 1105-1877.
9. Murdoch D. Amlodipine. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic use in cardiovascular disease / D. Murdoch, R. C. Heel // Drugs. - 1991. - № 41. - Р. 478-505.
10. Prevention of stroke and myocardial inhfarction by amlodipine and angiotensin receptor blockers: a quantitative overview / J. G. Wang, Y. Li, S. S. Franklin (et al.) // Hypertension. - 2007. -№ 50. - P. 181-188.
11. The ALLHAT officers and coordinators for the ALLHAT collaborative reaseach groop. Major outcomes in high-risk hypertensive patients randomized to ACE inhibitor or calcium-channel blocker vs diuretic // JAMA. - 2002. - V. 288. № 5. - P. 2981-2997.
12. U. S. Food and drug administration (fda), department of health and human services, food and drug administration center for drug evaluation and research (CDER), center for biologics evaluation and research (CBER): guidance for industry: population pharmacokinetics. - February 1999.
Review
For citations:
Kechin I.L., Fadi A.Z., Gladyshev V.V., Kechyn S.I. COMPARABLE PHARMACODYNAMICS OF TRADITIONAL AND RECTAL APPLICATION OF THE AMLODIPINE IN PATIENTS WITH ARTERIAL HYPERTENSION WITH HIGH RISK OF CEREBROVASCULAR COMPLICATIONS. Kuban Scientific Medical Bulletin. 2014;(1):101-106. (In Russ.)
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