STUDY OF INDOLE SS-68 DERIVATIVE IMPACT ON THE PRIMARY GENERALIZED CONVULSIONS INDUCED BY MAXIMAL ELECTRIC SHOCK, THIOSEMICARBAZIDE AND PILICARPINE
https://doi.org/10.25207/1608-6228-2017-24-3-17-21
Abstract
Aim. Study of SS-68 impact on primary generalized convulsions in basic estimation tests of anticonvulsant action of agents.
Material and methods. Study of the SS-68 impact on primary generalized convulsions included an estimation of anticonvulsant action with maximal electric shock, thiosemicarbazide and pilocarpine antagonism tests performed on white outbred male mice and rats.
Results. SS-68 compound possesses dosage dependent anticonvulsant action in maximal electric shock test indicating its ability to prevent death of 100% animals and its activity in thiosemicarbazide and pilocarpine antagonism tests as well. In the maximal electric shock test SS-68 surpassed sodium valproate in its anticolvulsant activity.
Conclusion. Neurotransmitter systems of the brain such as GABA, cholinergic and amino acid stimulant system as well as K+, Na+ and Ca2+ channels of neurons shall be the most possible molecular targets of SS-68 anticonvulsant action. Higher activity of SS-68 comparing with sodium valproate in the maximal electric shock test (increasing GABA content in central nervous system) can be related with its wide range of neurotropic action.
About the Authors
S. K. BOGUS
FSBEI HE KUBSMU of Health Care of Russia
Russian Federation
Russian Federation
Department of Pharmacology
350063, 4, Sedina St., Krasnodar. Tel. 8(861)262-34-99
I. G. COVALEV
FSBRI “Zakusov Research Institute of Pharmacology”
Russian Federation
125315, 8, Baltiyskaya St., Moscow
Russian Federation
125315, 8, Baltiyskaya St., Moscow
O. N. GULEVSKAYA
FSBEI HE KUBSMU of Health Care of Russia
Russian Federation
Russian Federation
Department of Pharmacology
350063, 4, Sedina St., Krasnodar. Tel. 8(861)262-34-99
K. F. SUZDALEV
Southern Federal University
Russian Federation
Russian Federation
Chemical Faculty, Natural and High-molecular Compound Department
344090, 7, Zorge St., Rostov-on-Don. Tel. 8 (918) 856-71-00
P. A. GALENKO-YAROSHEVSKY
FSBEI HE KUBSMU of Health Care of Russia
Russian Federation
Russian Federation
Department of Pharmacology
350063, 4, Sedina St., Krasnodar. Tel. 8(861)262-34-99
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Review
For citations:
BOGUS S.K., COVALEV I.G., GULEVSKAYA O.N., SUZDALEV K.F., GALENKO-YAROSHEVSKY P.A. STUDY OF INDOLE SS-68 DERIVATIVE IMPACT ON THE PRIMARY GENERALIZED CONVULSIONS INDUCED BY MAXIMAL ELECTRIC SHOCK, THIOSEMICARBAZIDE AND PILICARPINE. Kuban Scientific Medical Bulletin. 2017;(3):17-21. (In Russ.) https://doi.org/10.25207/1608-6228-2017-24-3-17-21
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