EFFECTIVENESS OF OZONE THERAPY IN REHABILITATION OF NEWBORNS AFTER INTRAUTERINE HYPOXIA
https://doi.org/10.25207/1608-6228-2017-24-5-45-49
Abstract
Aim. To estimate efficiency of inhalation ozone therapy at rehabilitation of newborns who had suffered from intrauterine hypoxia.
Materials and methods. The complex clinical laboratory research of the antioxidant status of 150 newborns was conducted. The control group included 30 almost healthy newborns whose mothers had no somatic diseases and were characterized by physiological gestation course. The group of comparison was presented by 45 newborns whose mothers had secondary chronic placental insufficiency and received drug treatment without the course of ozone therapy. 75 newborns whose mothers received ozone-air mixture inhalations along with traditional therapy entered into clinical group. The erythrocytes of newborns’ dark blood taken right after the birth were chosen as a material for the research. The activity of superoxide dismutases (SOD), catalases, glutathione peroxidases (GPO), glutathione reductase (GSR), glucose-6-phosphate dehydrogenase (G6PD), as well as concentration of the restored glutathione (GSH) were assayed.
Results. It was established that the compensatory and adaptive reactions providing elimination of the reasons of oxidizing stress development due to the stimulating influence of ozone on activity of antioxidant protection enzymes were formed in newborns of clinical group.
Conclusion. In this regard, the offered scheme of the ozone therapy can be recommended for a complex rehabilitation of pregnant women with the chronic secondary placental insufficiency against the background of cardiovascular diseases.
About the Authors
Z. I. MIKASHINOVICH
Federal State Budgetary Educational Institution of Higher Education "Rostov State Medical University", Ministry of Healthcare of the Russian Federation
Russian Federation
per. Nakhichevansky, d 29, Rostov-on-Don, Russia, 344022
Russian Federation
per. Nakhichevansky, d 29, Rostov-on-Don, Russia, 344022
I. A. LOGINOV
Federal State Budgetary Educational Institution of Higher Education "Rostov State Medical University", Ministry of Healthcare of the Russian Federation
Russian Federation
per. Nakhichevansky, d 29, Rostov-on-Don, Russia, 344022
Russian Federation
per. Nakhichevansky, d 29, Rostov-on-Don, Russia, 344022
A. A. BORSHCHEVA
Federal State Budgetary Educational Institution of Higher Education "Rostov State Medical University", Ministry of Healthcare of the Russian Federation
Russian Federation
Russian Federation
per. Nakhichevansky, d 29, Rostov-on-Don, Russia, 344022
phone:+7 (918) 554-01-83; Russia, 344082, Rostov-on-don, Bratskiy per., d. 48, kv. 13
References
1. Агеева Л.И., Александрова Г.А., Зайченко Н.М. и др. Здравоохранение в России: 2015. Статистический сборник/ Росстат. М., 2015: 174. [Ageeva L. I., Alexandrova G. A., Zaychenko N. M. et and. Health care in Russia: 2015. Statistical collection / Rosstat. M, 2015: 174. (In Russ.)].
2. Радзинский В.Е. Акушерская агрессия. М.: Издательство журнала Status Praesens, 2011: 688. [Radzinsky V. E. Obstetric aggression. M.: Publishing house of the Status Praesens magazine, 2011. 688 p. (In Russ.)].
3. Радзинский В.Е. Акушерская агрессия, v. 2.0. М.: Издательство журнала Status Praesens, 2017. 872 с. [Radzinsky V. E. Obstetric aggression, v. 2.0. M.: Publishing house of the Status Praesens magazine, 2017: 872. (In Russ.)].
4. Микашинович З.И., Олемпиева Е.В., Шлык С.В. и др. Метаболические аспекты внутриутробной гипоксии плода при сердечнососудистой патологии у беременных. Ростов-на-Дону: ГОУ ВПО «РостГМУ Росздрава», 2008: 158. [Mikashinovich Z. I., Olempiyeva E. V., Shlyk S. V., Loginov I. A. Metabolic aspects of a pre-natal hypoxia of a fruit at cardiovascular pathology at pregnant women. Rostov-on-Don: GOU VPO «RostGMU Roszdrav», 2008: 158. (In Russ.)].
5. Радзинский В.Е., Смалько П.Л. Биохимия плацентарной недостаточности. М.: Издательство РУДН, 2001. 273 с. [Radzinsky V. E., Smalko P. L. Biokhimiya of placentary insufficiency. M.: Publishing house RUDN, 2001: 273. (In Russ.)]
6. Стрижаков А.Н., Тимохина Е.В., Игнатко И.В. и др. Патофизиология плода и плаценты. М.: ГЭОТАР-Медиа, 2015: 176. [ (In Russ.)]
7. Формирование и патология плаценты // Под ред. В.И. Краснопольского. М.: ОАО «Издательство «Медицина», 2007: 112. [Placenta: formation and pathology / Ed by V.I. Krasnopolsky. Moscow: Meditsina Publishers, 2007: 112. (In Russ.)].
8. Новикова С.В., Туманова В.А., Логутова Л.С. и др. Компенсаторные механизмы развития плода в условиях плацентарной недостаточности // Под ред. В.И. Краснопольского. М.: Издательство «Медкнига», 2008: 298. [Novikova S. V., Tumanov V. A., Logutova L. S., et and. Compensatory mechanisms of development of a fruit in the conditions of placentary insufficiency // Under the editorship of V. I. Krasnopolsky. M.: Publishing house «Medkniga», 2008: 298. (In Russ.)].
9. Олемпиева Е.В., Микашинович З.И. Молекулярные механизмы развития окислительного стресса при осложненном течении беременности. Клиническая лабораторная диагностика. 2008; 10: 17-19. [ Olempiyeva E. V., Mikashinovich Z. I. Molecular mechanisms of development of an oxidizing stress at the complicated course of pregnancy. Clinical laboratory diagnostics. 2008; 10: 17-19. (In Russ.)].
10. Абрамченко В.В. Антиоксиданты и антигипоксанты в акушерстве. СПб.: Издательство ДЕАН, 2001: 400. [Abramchenko V. V. Antioxidants and antigipoksant in obstetrics. SPb.: DEAN publishing house, 2001: 400. (In Russ.)].
11. Олемпиева Е.В., Микашинович З.И., Шаповалова Е.И. Клинико-биохимический мониторинг хронической фетоплацентарной недостаточности. Вестник РУДН. 2008. №7. С. 424-427. [Olempiyeva E.V., Mikashinovich Z.I., Shapovalova E.I. Kliniko- biokhimichesky monitoring of chronic fetoplatsentarny insufficiency. RUDN bulletin. 2008; 7: 424-427. (In Russ.)].
12. Олемпиева Е.В., Коваленко Т.Д., Логинов И.А. Особенности перестройки метаболизма газотранспортной функции крови у беременных при применении медицинского озона в акушерской практике. Вопросы курортологии, физиотерапии и лечебной физической культуры. 2011; 6: 33-35. [Olempiyeva E. V., Kovalenko T. D., Loginov I.A. Features of reorganization of metabolism of gas transmission function of blood at pregnant women at use of medical ozone in obstetric practice. Questions of balneology, physical therapy and medical physical culture. 2011; 6: 33-35. (In Russ.)].
Review
For citations:
MIKASHINOVICH Z.I., LOGINOV I.A., BORSHCHEVA A.A. EFFECTIVENESS OF OZONE THERAPY IN REHABILITATION OF NEWBORNS AFTER INTRAUTERINE HYPOXIA. Kuban Scientific Medical Bulletin. 2017;(5):45-49. (In Russ.) https://doi.org/10.25207/1608-6228-2017-24-5-45-49
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