THREE-DIMENSIONAL ECHOGRAPHIC EVALUATION OF CHORION VASCULARIZATION IN 1st TRIMESTER OF GESTATION IN WOMEN WITN THROMBOFILIA
https://doi.org/10.25207/1608-6228-2018-25-6-19-25
Abstract
Aim. Determine the threshold values of quantitative indices of chorionic volume flow in pregnant women with thrombophilia in the first trimester of pregnancy for the prediction of miscarriage and evaluate the effectiveness of anticoagulant therapy.
Materials and methods. Ultrasound examination of the embryo and extraembryonic structures with volume reconstruction of the chorion and determination of quantitative indices using VOCAL program − vascularization index (VI), flow index (FI), vascularization flow index (VFI) in women with thrombophilia from 7th to 10th of the week of gestation.
Results. The analysis of the quantitative parameters VI, FI and VFI in pregnant women in the first trimester showed high reliability (p<0.001) in the value of VI and VFI in pregnant women with thrombophilia without treatment and in the pregnant control group, as well as in pregnant women with thrombophilia before and after anticoagulant therapy. Among the most informative parameters for assessing the chorion vascularization in predicting miscarriage VFI≤7,80 has highest value for negative outcome. Index VI due to the very high specificity (SP = 82.6%) better more informative for predicting a favorable outcome.
Conclusion. The use of the proposed method allows us to identify a risk group for predicting miscarriage in the first trimester in pregnant women with thrombophilia and promptly prescribe anticoagulant therapy and evaluate its efficiency.
About the Authors
M. A. AsriyantsRussian Federation
Sedina str., 4, Krasnodar, 350063.
O. V. Astafieva
Russian Federation
Sedina str., 4, Krasnodar, 350063.
V. G. Shcherbina
Russian Federation
Sedina str., 4, Krasnodar, 350063.
References
1. Kukharchik Yu.V., Gutikova L.V. Modern methods of diagnostics of recurrent early pregnancy loss. Educational Establishment "Grodno State Medical University", Grodno, Belarus. 2012; 4(40): 23-25. (In Russ.).
2. Zaynetdinova L.F., Kurenkov E.L., Nigametzyanova G.R. Comparison of anamnestic data of women with different forms of non-developing pregnancy. Human. Sport. Medicine. 2015; 2: 52-57. (In Russ). DOI: 10.14529/ ozfk150209.
3. Pfeffer P.L., Pearton D.J. Trophoblast development. Reproduction (cambridge, england). 2012; 143: 231-246.
4. Ozolinya L.A., Lapina I.A., Nesterova A.O. Thrombophilia in Obstetrics and Gynecology: a Literature Review. Bulletin of RSMU. 2014; 4: 80-85. (In Russ.).
5. Pestrikova T.Yu., Porubova I.P. Hereditary thrombophilia in women with infertility, join the programme assisted reproductive technology. Far East Medical Journal. 2014; 1: 119-122. (In Russ.).
6. Kaneva F.M., Frolov A.L., Akhmetova V.G., Khusnutdinova E.K., Gilmanov A.Zh. The characteristics of hemostasis condition in women with non-carrying of pregnancy. Russian clinical laboratory diagnostics. 2012; 8: 37-41. (In Russ.).
7. Soares M.J., Chakraborty D., Renaud S.J., Kubota K., Bu P., Konno T., Rumi M.A.K. Regulatory pathways controlling the endovascular invasive trophoblast cell lineage. Journal of reproduction and development. 2012; 58: 283-287.
8. Cui Y., Wang W., Lou J., Srinivasan D.K., Peng J., Chen S., Wu S., Wu Q., Dong B., Liu M., Fang C., Liu Z., Dong L., Zhou Y., Cheng W., Huang X. Role of corin in trophoblast invasion and uterine spiral artery remodelling in pregnancy. Nature. 2012; 484: 246-250.
9. Fоmina M.P. 3d doppler ultrasound of placental blood flow in the prediction of a missed miscarriage. Bulletin of Peoples’ Friendship University of Russia. Series medical. 2013; 5: 44-50. (In Russ.).
10. Kryukova, N. I. Early prediction of placental insufficiency in pregnant women of late reproductive age. Mother and Child in Kuzbass. 2012; 1: 44-48. (In Russ.).
11. Chaika, V.K. Features of the chorion blood volume flow and Doppler blood flow characteristics in the uterine arteries in pregnant women with the threat of interruption in the first trimester against the background of hypoprogesteronemia. Medical and social problems of the family. 2012; 17(3): 13-22. (In Russ.).
Review
For citations:
Asriyants M.A., Astafieva O.V., Shcherbina V.G. THREE-DIMENSIONAL ECHOGRAPHIC EVALUATION OF CHORION VASCULARIZATION IN 1st TRIMESTER OF GESTATION IN WOMEN WITN THROMBOFILIA. Kuban Scientific Medical Bulletin. 2018;25(6):19-25. https://doi.org/10.25207/1608-6228-2018-25-6-19-25
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