A wide range of rotating nickel-titanium instruments on the dental market where manufacturers provide only exemplary resource mechanical tools conventionally dividing them into reusable and disposable, thus, does not give advice on operation time and clinical recommendations depending on system complexity root canal, cry a lot of questions. The paper discusses the results of experimental and clinical research cycle fatigue machine endodontic NiTi instruments. Dental phantom «Model for determining the fatigue strength of mechanical endodontic instruments in root canal preparation of teeth» to determine the cyclic durability of mechanical endodontic instruments reasonably choose endodontic nickel-titanium instruments of a certain size and taper depending on the angle of the root canal bending teeth in the clinic, thereby warning possible tool breakage risks in the processing of root canal during treatment.

Article is devoted to clinicoradiological evaluation of quality of endodontic treatment of destructive forms of chronic apical periodontitis as a result of the application of the material for filling root canals in the treatment of granulomatous and granulating forms of chronic periodontitis. This material was used in the treatment of 86 teeth in 46 patients aged 18-65 years in clinic. It was established that the material is allowed to reliably obturated root canal, to stop inflammation in the periodontal stimulate repair processes in the periapical tissues. This has been confirmed in long-term period on the basis of X-ray cone beam computed tomography in accordance with the scale of Hounsfield. The first radiographic appearance of the beginning of reparative regeneration of bone tissue in the main group appeared on 32,8±0,5 days. The same factors appeared on 49,7±0,4 days in control group. Bone defect restoration around the hearth of destruction in the main group took, on average, 64,8±0,5, against 98,7±0,3 days in the control group. Methods of cone beam computed tomography allows the remote period after endodontic treatment to dynamically control the state of the bone-destructive foci of chronic apical periodontitis (granulating and granulomatous pathological forms) and define the rate of regeneration of bone tissue. It allows you to objectively evaluate the degree of bone regeneration in the destruction of the hearth.

The article presents the results of studies of metabolic indicators of oral liquid in patients with a wide range of somatic illnesses that reflecting the functional state of the prooxidant-antioxidant system. During the studies established that most increase in activity of oxidation processes in the background of decrease in activity of all enzymes of antiradical protection was observed in patients with diabetes mellitus type 2. Also a significant increase in FRO was observed in patients with chronic obstructive pulmonary disease, while they have identified imbalance in the functioning of enzyme systems and the highest amplitude changes in the activity of enzymes of antiradical protection. We also established the activation of free radical processes in patients of other groups, but less pronounced on the background of a minor changes in the activity of enzymes. The obtained data demonstrate the development of oxidative stress at the local level in the oral fluid which is probably a reflection of the systemic metabolic changes under examined somatic pathologies and presents prospect of studying oral fluid in the laboratory diagnosis of oxidative metabolism disorders.

Periodontal diseases are currently one of the most important issues in dentistry. The aim of our work was to study the clinical efficacy of osteoplastic material «Bio-Gene» in the treatment of chronic periodontitis and its influence on periodontal tissue microcirculation. Application of osteoplastic preparation «Bio-Gene» in the surgical treatment of chronic periodontitis demonstrates a pronounced therapeutic effect and improvement of microcirculation. It can be recommended to a wide dental practice, and apply the laser Doppler flowmetry for the complete information in the clinical setting of the state of microcirculation in periodontal tissues non-invasive method.

Laboratory and diagnostic methods were used to perform quantitative assessment of natural microbial colonization in buccal epithelium in children (adolescents) aged 10-15 years with an optimal functional occlusion and malocclusion, and resistance of their buccal epithelial cells to artificial microbial colonization was studied as well. It was found that patients with dentoalveolar abnormalities characterized with morphological and functional disorders of varying degrees, showed dysbiotic changes in the mucosal epithelium, reflecting the severity of destabilizing processes in the oral homeostasis, and selective decrement in colonization resistance of mucous membranes due to the changes in the adhesive properties of the epithelium.

Result evaluation of complex treatment is very important at the final stage of rehabilitation of the 17-24-year-old patient with a unilateral cleft lip and palate (UCLP). During this period, it can be relatively easy to assess the defects and mistakes of treatment at previous stages, and to fix themif it is possible. Possibility of occlusion correction increases after a thorough analysis of the previous stages of complex rehabilitation of disabled children with UCLP. This increases the doctor motivation to medical history survey of the child and to a more accurate registration of objective data. This creates optimal conditions for the planning of further orthodontic and orthopedic treatment and comparing the results to the moment of rational prosthetics.

In the present study we investigated the clinical and immunological evaluation of inclusion into medical complex in phlegmon of the maxillofacial region leukinferon immunomodulatory drug. The study included 100 patients with phlegmon of the maxillofacial region, randomized into 2 groups: I group consisted of 50 people who received conventional treatment; II group consisted of 50 people, in a comprehensive treatment that was included leukinferon. The data on the marked immunomodulatory effect on neutrophil granulocytes leukinferon system, as well as cell-mediated immunity. These effects provide a rapid withdrawal of patients from the state of secondary immune deficiency. Clinically, patients of group II marked a more effective relief of endogenous intoxication, shortening wound cleansing, shortening imposition of secondary sutures and overall duration of treatment in the hospital compared with patients in group I.

There is a high level of intensity and prevalence of dental hard tissue diseases in children with neuropsychiatric disorders. Taking into account the difficulty and specificity in the treatment of this category of children, in particular, the impossibility of full cavity necrectomy, the problem of caries complications after treatment is relevant. For high quality tooth decontamination before filling, we suggested to use the bactericidal properties of the laser beam (810 nm), because the creation of «sterile» cavity is one of the most important components of a favorable prognosis of treatment. The proposed method of treatment is effective due to the full bactericidal effect, reduces the risk of complications and can serve as an alternative to the previously proposed methods for the treatment of acute decompensated form of caries.

The prevalence of periodontal diseases of varying severity affects more than 90% of the adult population, and the problem of increasing the effectiveness of its treatment is very important. One of the promising methods of treatment is antibiotic therapy with the use of probiotic microorganisms and antioxidants. The contomitant use effectiveness of antibacterial BTC-therapy, Linex probiotics® and Xylax forte®, antioxidant ubixion (coenzim Q 10) for microbiocenosis gingival pockets' sanation was investigated on 60 patients with inveterate severe generalized periodontitis. It was found that pathogenic microflora volume decreased in 21,3±0,7(p<0,05) and treatment efficacy increased in 4,9±0,3 (p <0,05) times.

This article discusses the various aspects of bacterial contamination before and after treatment of chronic periodontitis and the choice of drug for the temporary investment of the root canal. As a result of the study revealed the presence of a bacterial pathogen in the root canal at the time of filling a permanent, that is a risk factor for apical periodontitis. Analysis of radiological and microbiological data for 24 months, lead to the conclusion that the paste for the temporary filling of root canal for the treatment of chronic apical periodontitis of the components calcium hydroxide, ciprofloxacin, minocycline, metronidozol, mixed with 2% chlorhexidine solution bigluconate well tolerated It has no side effects and contraindications. The data obtained allow to recommend the proposed paste for effective treatment of destructive forms of chronic periodontitis.

The frequency of occurrence is studied. The characteristic of the main dentoalveolar anomalies at recruits (entrants) and cadets of the highest military educational institutions taking into account features of medical examination of citizens at initial statement on the military account and military draft is submitted. Defects of work of the military-medical commissions of the young people who are carrying out examination preparing for entering in the HMEI are shown. The existing difficulties in ensuring the orthodontic help in conditions of military service are noted. The conclusion is drawn on need of the solution of problems of examination of young people at initial statement on the military account and military draft. It's drawn in connection with dentoalveolar anomalies which are available for them which demand specification, as in the medical, and legal plan.

The results of adipose tissue autotransplantation in patients with different etiology of local facial soft tissue deficiency were estimated. The basic group (BG, n=105) was treated with vascular stromal cell fraction (VSCF) enriched fat, and control group (CG, n=98) with pure fat. The better outcomes after unitary operation (2,0±0,1 against 1,4±0,1 according to GAIS ratings; p<0,01) and smaller quantity of procedures for optimum aesthetic result (1,7±0,1 against 2,1±0,1 for one patient; p<0,01) were observed in BG at comparison with CG. On МРI data it is shown VSCF has a strong influence on the dynamic re-modelling processes in transferred adipose tissue what promotes adipocites survival and tissue regeneration. Thus, results of our study indicate superior efficiency of the suggested cell-assisted surgery technology in comparison with traditional liportansfer.

The article presents the results of estimation of efficiency of complex treatment of diseases of the mucous membranes of the oral cavity in individuals with low, medium, high degrees of contamination of the stomach Helicobacter pylori structure of Helicobacter pylori-associated diseases of the mucous membranes of the oral cavity, assessment of the state of local immunity of oral cavity in this category of patients. The proposed scheme of general and local treatment of diseases of the mucous membranes of the oral cavity for these patients, the main stages of which should be: normalization of the microbial landscape of the mucous membranes of the oral cavity and mucous membranes of the gastrointestinal tract, restoration of acid-base balance of the oral cavity; prevention of reinfection of the mucous membranes of the oral cavity and gastrointestinal tract Helicobacter pylori.

Dental morbidity remains high, and has no tendency to stabilize. In our country it is being actively targeted study of the incidence of dental professionals hazardous industries, the aim of which is to determine the impact of production factors on the dentition system. Prevalence of stomatologic diseases at health workers of clinic of Rostov state medical university is studied and extent of etiological influence of production factors in development of the taped pathology is estimated. It is established that the stomatologic case rate is registered at employees of clinic with harmful working conditions more often, it is characterized by a variety of nosological forms and activity of pathological processes. Changes of firm tissues of teeth differ in intensity of carious disturbances and larger spread of not carious pathology, and diseases of tissues of a parodont are characterized by more serious current.

Questions of diagnosis and treatment of diseases of the salivary glands extensively researched the leading clinics of maxillofacial surgery and dentistry dental universities and medical academies. Features of a microcrystallization of oral liquid at adults of the different age groups having various chronic diseases of sialadens are studied. In work it is surveyed 246 (115 men and 134 women) aged from 25 till 82 years suffering from a chronic sialadenitis (sialodochitis), sialolithic illness (sialolithiasis), reactive and dystrophic diseases of sialadens (sialoses), radial and medicamental sialoadenopathia, and also good-quality and malignant neoplasms of sialadens. Dependence of crystallographic indicators of the saliva, both from a type of pathology of sialadens, and from age and the level of a comorbidity of adults is established.

The high prevalence and increasing the intensity of the main dental diseases in women during pregnancy is a big social problem. The effect of enhancing production of hormones during pregnancy affects the dentition, which increases the risk of dental disease. A major role in local immunity play an antimicrobial peptides, for regulating inflammatory processes and initiate an immune response. The present study investigates the dynamics of antimicrobial peptides in dental pathology in pregnant women. Pregnant women suffering from dental caries, a marker of activity of the process of local factors is lactoferrin. Patients with periodontitis mild to moderate increase in joint lactoferrin and C-reactive protein levels in saliva have been an indicator of high studied pathogenetic significance of dental disease in pregnancy.

Research of the cytokines level as the peptides molecules, that regulates individual development, physiological functions and organism protective reactions, gives the information about cells functional activities. Today we know age specialties of cytokines level among healthy children, that shows its strong connection with the immune and endocrine systems regulation development and functioning. Cytokines play important role in development of the inflammation processes including oral cavity mucosa inflammation, while its system contents depends on clinical manifestation of this face pathology. This investigation aims at studying the blood cytokines level in children of different age groups with congenital cleft lip and palate on different stages of surgical treatment.

Physiological basis of biofeedback is quantitatively measured flow of information that can be compared and matched with the current state of the human body at successive time intervals. This impact assessment is carried out in neuronal structures by comparing the received signals with references in the short-term and working memory. The result is a state of matching or mismatch, resulting in the consolidation of certain functional system or reconfiguring. This allows the patient to learn self-regulation and modification investigated or regulated physiological function. Application of the method of phonetic oscilloscope provides for the possibility of both visual and sound control zvukoproiznoshenija, can be used to normalize the latter, and, consequently, be regarded as «adaptive biofeedback biofeedback».

Currently, dentistry is developing by leaps and bounds. With a huge number of new diagnostic and treatment methods, to a dentist there is a problem proper, reasoned choice. No exceptions are and diseases of the oral mucosa. Increasing interest on the diagnosis of the microvasculature acquires laser Doppler flowmetry. Since inflammatory-destructive diseases of the oral mucosa is necessary to provide not only local therapeutic treatment, namely to work on one of the causes of this disease. In this paper we evaluated the microcirculation in patients with oral lichen planus by laser Doppler flowmetry. These data show not only the deterioration of the microcirculation in the hearth direct inflammation, but not altered in clinically mucosa symmetrical areas.

Currently, dental implantation has taken a leading position in the complex treatment of various dental diseases as the main and the most progressive method of restoring the quality of life of patients. Work is devoted to studying of implants survival at 29 patients of specialized unit of multi-speciality hospital. 68 zygomatic implants and 137 root dental implants were set up to these patients. Implants were set up to get stomatologic rehabilitation of patients with the acquired adentia of jaws. The comparative assessment of survival of zygomatic and dental implants was carried out, the period of observation was 36 months. The assessment of survival of root dental implants at all patients operated for the reporting period of time was carried also out.

The article analyzes the results of dental examination of employees to hazardous and normal working conditions at the company Atomenergomash based on the previous organization of dental care; provided clear evidence of the effectiveness of outpatient care workers in terms of reduction in the dental treatment needs. It was found that the dispensary method of dental care with an annual treatment of dental and periodontal provides a significant reduction in the intensity of dental diseases and the need for dental treatment of patients with hazardous working conditions of workers. At clinical examination prevails therapeutic and preventive effects on periodontium. The need for replacement of dental hard tissue defects and endodontic treatment 2 times less, replacing the seals and audit root canal - 4 times.

The authors present the results of the study of hospital morbidity of different nosological forms of maxillofacial pathology in the adult population of the Krasnodar region in 2015 in the sex and age distribution. In the structure of pathology inflammatory diseases (65.2%), neoplasms (18.8%) and injuries (15.1%) predominate. Hospital incidence of various forms of maxillofacial pathology in male population was significantly higher than that of women's (331,6 and 212,3 per 100 thousand population respectively). In the age group 18-29 the highest value of this indicator - 338,6 per 100 thousand population - has been determined.

The morphological and functional abnormalities in the tooth-jaw-facial area combined with various parodontopatii. This complicates the diagnosis, treatment and prediction of treatment outcomes. Often such a complicating factor is the clinical hypertrophic gingivitis. 13teen-agers with distal deep overbite accompanied by hyperplastic juvenile gingivitis, were orthodontically treated by non-removable technique Stright Wire Technique. Periodontic treatment included BTL-therapy by diode laser «Latus» and gingivectomy by СО₂-laser «Opus Duo», USA. There was stated a topico-morhphometric facial skill improvement after orthodontic apparatus periodontic status amelioration after laser therapy treatment, that promoted curing results stability together with favorable forecast of post-treatment period.

It is known that the laser emission in the red and infrared (IR) at therapeutic doses on the molecular level stimulates the redox processes, increases the rate of protein synthesis, enzymes, membrane potential changes at the cellular level, increases the proliferative activity. The present study evaluated the effect of a semiconductor laser on the activity of alkaline phosphatase in uncomplicated bone fracture of the lower jaw and traumatic osteomyelitis. The study was conducted on 170 Wistar rats. Total generated 5 groups. The animals were irradiated by an infrared laser, the exposure was 10 minutes. Detected laser stimulating effect on the enzyme activity of bone pathology for modeling bone, which provides a favorable clinical effect of the treatment.

For many years, is searching for new effective agents for the treatment of periodontal disease, improving methods of their administration directly into the affected tissue. Proposed methods of treatment should have a sustained impact on periodontal tissue. The article presents the results of a study on the development of methods of application of medical adhesive composition and the study of its efficacy in complex treatment of inflammatory periodontal diseases using non-removable prosthetic dental implants. Analysis of clinical and laboratory studies have shown that medical adhesive composition based cyanacrylate and miramistin antimicrobial effect and stimulates the healing process of periodontal tissue.

Periodontitis - is a multifactorial disease of the tooth supporting-holding unit caused by microbial plaque. In patients with chronic generalized periodontitis in conjunction with iron deficiency anemia standard dental treatment is not effective in most cases. To achieve long-term and stable remission in these patients can only be combined comprehensive periodontal treatment, including subsequent maintenance therapy, and treatment of iron deficiency anemia. Dispensary observation of patients should be carried out at least 1 time in 3 months with control of basic periodontal indices and the correction level of oral hygiene. In some cases, it is recommended to reduce the interval between visits.

The results of the research in enzyme link of the antioxidant system as well as the activity of acid and alkaline phosphatase and amylase in mouth liquid of children from two age groups (8-12 years and 13-17 years) with parodentium disorders against the background of psychoneurologic disorders are presented in this article. The similar changes are detected in both groups, ex. the increase in activity of antiradical protection enzymes, phosphatases and the decrease in activity of amylase. The received data demonstrate the possibilities for laboratory severity assessment of the pathological process in oral cavity and of the effectiveness of ongoing therapy. Another prospective area is the development of screening research of the mouth liquid's metabolic status which enables the prevention of parodentium pathology and of its complications in high-risk patients including children with psychoneurologic disorders.

Prevalence of chronic inflammatory periodontal disease indicates the feasibility of improving the methods of diagnosis and therapy. Background diseases accompanied by disorders of blood supply to the periodontal, can seriously affect how the formation, and the severity of the disease in the tissues of dentition. The article presents the results studying of the clinical course of periodontal inflammatory diseases in 130 patients at the age of 25-44 years with a variety of background conditions in blood pressure (50 - with arterial hypotension, 42 - with hypertension, 38 - with normal blood pressure) The data show a significant contribution of hemodynamic disturbances in the formation and severity of the clinical course of chronic periodontitis in patients with pathology of systemic hemodynamics.

In order to identify prognostic criteria of the effectiveness of treatment of ovarian cancer on the material of 59 patients a retrospective comparison of results of preoperative ultrasound in the B-mode; colour, power and spectral Doppler mapping in relapse-free subgroup and at relapse was conducted. It was found that the negative prognostic criteria are: tumor volume more than 100 cm³, fuzzy rough outlines, central or mixed blood flow with neovascularization by hypervascular type, highspeed blood flow indicators (Vps>50 cm/s), low values of hemodynamic indices (RI<0.40, PI<0.90). The development of the doppler-defined arteriovenous shunts with signs of turbulent or mixed (arterial and venous) blood flow in tumors is a highly informative unfavorable prognostic sign.

Study of gum disease and salivary glands often involves the study of mast cells, which are known to belong to a group of cellular factors innate immunity. The purpose of this investigation was to determine characteristics of the cytoplasmic biopolymers of the mast cells in gums and large salivary glands in human being during 23 solar cycle with the help of histochemical staining. The material was taken from men, who got dead during road accident. With the help of the investigation results can make the conclusion, that characteristics of the gingival and large salivary glands mast cells have seasonal character. And characteristics of the mast cells of the gingiva and parotid glands , besides seasonal character, have chronobiological component that is under the influence of the solar cycle maximum phase.

The regularity of the splenic flexure mobilization during operations for rectal cancer is called in question. To assess if the splenic flexure mobilization during rectum resection has an impact on early postoperative complications rate, mortality and the number of lymph nodes examined. Prospective comparative study. 940 patients underwent a selective surgery for colorectal adenocarcinoma T_1-4N_0-2M_0-1 during 2003-2014. Patients were divided into two groups: with the splenic flexure mobilization (n = 359), and without splenic flexure mobilization (n = 581). The early postoperative complications rate did not have statistically significant difference. Postoperative mortality had statistically insignificant difference (1,1% vs. 2,9%, p = 0.06). The number of examined lymph nodes increases if the splenic flexure mobilization is performed (13±7,3 vs. 10,6 ± 6,6, p <0.001). The splenic flexure mobilization has no impact on the postoperative complications rate, anastomotic leakage rate and postoperative mortality. The number of examined lymph nodes is not sufficient in case of splenic flexure mobilization withholding and that may cause understaging.

A comparative study of the effect of various drugs on experimental purulent wound healing by evaluating the time and the number of neutrophils and fibroblasts in smears at 1, 4, 8, 12 and 14 days from the date of the formation of purulent wounds. Solutions at a specially designed silver nan cluster, whose effectiveness was compared with the effectiveness of officinal solution of silver and treatment under the ointment patch. Revealed acceleration of healing of experimental wounds festering 1,9 days under the influence of the developed solutions of silver nanoparticles in comparison with the use of bandages and ointment by 4,4 days in comparison with the use of officinal solution of silver.