In this paper presents an experimental study of the effect of biologically active supplementation with antioxidant complex composition, sodium dichloroacetate and water with reduced deuterium content in the development and course of an allergic reaction in ovalbumin immunized rats. The development of experimental immediate hypersensitivity accompanied by increase of total IgE production to 5,8 times, and the imbalance of the cytokine, with a predominance of Th2-cytokine and decreased activity of Th1-lymphocytes. The studied biologically active supplement has proved its antioxidant properties, when using it was observed activation of catalase and glutathionereductase in ovalbumin-immunized rats but positive effect on cytokine and immunoglobulin status is not provided. Rats injections of sodium dichloroacetate and water with reduced deuterium content have an immunomodulatory effects that canceled imbalance of IL4/IFNγ relation with the normalization of IgE production. This is significant for possibility of correction of immunological disturbances in atopy by targeted displacement Th1 / Th2 balance using immunomodulator pathogenesis action.

The problem of treatment of cervical pregnancy refers to the topical issues of modern gynecology. Existing methods of radical surgical treatment leads to permanent loss of reproductive function of patients. The development of endovascular surgery techniques has allowed to minimize the amount of surgical intervention and preserve the reproductive potential of patients. During the work process was analyzed the experience of the treatment of cervical pregnancy with selective embolization of the uterine arteries at the base of the gynecological department of 2nd Regional Clinical Hospital. These results allow us to recommend this method for the treatment of this form of ectopic pregnancy gynecological hospitals.

The presence in the gastric mucosa herpesvirus infection in chronic erosive gastritis associated with Helicobacter pylori, can cause pathological processes, leading to exacerbation of the disease. The use of cycloferon on the background of eradication therapy can reduce the frequency of exacerbations of the disease and prolong remission.

Is carried out the analysis of the frequency of the development of different agents of pyoinflammatory complications in patients with the nefrologicheskimi diseases from the department of anasteziologo – resuscitation of Regional Clinical Hospital № 1 within the period s 2013 on 2015 the yr. In the time of a study it was identified 902 the culture of the agents more than 30 species. Among them gram-negative bacteria composed 42,1 %, gram-positive – 38,8 % and 19,1 % from all agents there were yeasts of the genus Candida. More frequent than others were separated the enterococcuses: 171 strains of Enterococcus faecalis, 150 of strains E. faecium and 148 cultures Klebsiella pneumoniae.

Estimate the efficiency of using L-Lysine Aescinat preparation in classical trigeminal neuralgia (TN) complex therapy. 38 patients with classical TN were examined. The number of male patients was 6, and the number of female patients was 32. All the patients were divided into two groups. The first group consisted of 17 patients taking L-Lysine Aescinat in the course of conventional complex therapy. The second group consisted of 21 patients receiving conventional complex therapy without taking L-Lysine Aescinat. Revealed statistically significant decrease of indicators such as the degree of pain to the visual analogue scale (VAS), pain episodes, severity of trigeminal pain syndrome Barrow Neurological Institute (BNI) in the compared groups. The introduction of L-Lysine Aescinat into classical trigeminal neuralgia (TN) complex therapy statistically reduces the frequency of pain episodes and improves indices such as pain severity and BNI score.

The influence of compound SS-68, known for its marked antiarrhythmic properties, on the intension of electrophysiological effects of α1- и β- adrenoreceptors stimulation was studied in right atrial preparations from rat. Activation of α1-adrenoreceptors by methoxamine (3×10-5М) led to prominent prolongation of action potentials without significant changes in their rhythm. SS-68 attenuated this effect with IC50 = 5,27×10-6М. The standard α1-blocker prazosine appeared to be more effective (IC50 = 2×10-7М). The activation of β-adrenoreceptors by isoproterenol (3×10-7М) led to drastic acceleration of sinus rhythm. However, only the highest tested concentration of SS-68 (3×10-5М) reduced this effect, while the conventional β-blocker atenolol effectively inhibited it with IC50 = 3,95×10-6М.

The article discusses the study of effect of exogenous glucosamine hydrochloride and chondroitin sulfate on the synthesis of nucleic acids in experimental gingivitis. Experimental model of gingivitis were formed at 40 white Wistar rats, were formed: the control and main groups, further investigated the periodontium in 20 intact animals. Evaluation of the effect of exogenous glucosamine hydrochloride and chondroitin sulfate on the synthesis of nucleic acids in experimental gingivitis conducted at the level of morpho-functional activity of fibroblasts, which was judged by the degree of dispersion of the chromatin. The study found a positive effect of exogenous glucosamine hydrochloride and chondroitin sulfate on the course of experimental gingivitis, which is manifested by increasing the morphofunctional activity of fibroblasts.

The goal of the work was to evaluate anesthesia according to the central hemodynamic, oxygen, acid-base, temperature homeostasis, neuromuscular conduction monitoring the depth of anesthesia and recovery postanesthesia consciousness. The research was performed in 102 patients who underwent major abdominal surgery under combined anesthesia with sevoflurane and ropivacaine. All patients were divided into 4 groups depending on the characteristics induced dynamics of constant potential. Anesthesia in patients with high reactivity and areactivity cardiovascular and respiratory systems characterized by unstable hemodynamic status and the need for the use of vasopressors. Anesthesia in patients with optimal and low reactivity characterized by hemodynamic stability.

The paper presents the results of development of the syrup of lime flowers heart-shaped. The proposed technological scheme of production. Defined critical process parameters in the production of syrup of lime: pH, temperature, number of revolutions of the stirrer microbiological purity. The determination of microbiological purity and the study of the organoleptic properties of the obtained syrup lime.

Research goal was an evaluation of survival and electroencephalographic (EEG) indices in rats with experimental cerebral ischaemia (ECI) during the preventive application of cerebroprotective drugs: nootropics (piracetam (300 mg/ kg/day) and vinpocetine (5 mg/kg/day)) in combination with melaxen (0,25 mg/kg/day). Global CI was modelled by left and right common carotid arteries (CCA) ligation. It was founded that preventive combined application of vinpocetine and melaxen reduced significantly (about 2.5 times (р≤0,01)) rats lethality and influence of circulatory ischemia adverse effects on survived experimental animals brain functional state. Only in the rats receiving these drugs were registered frequency ranges close to the baseline, specifically, theta (θ)-rhythm was dominated over delta (Δ)-activity, indicating waking state of the rats’ brain. The results obtained can be used in clinical practice for prevention and treatment of ischemic brain diseases.

With the help of common hystologic methods in comparative aspect the thickness of some layers of walls of spleen and portal vein in normal condition and at syndrome of portal hypertension at children and adults. Studying of hystotopography and hystometrii of veins in age aspects showed not only peculiarities of formation, but patterns of age pathomorphologic changes of some parts of the walls. At portal hypertension the increase or decrease of thickness of muscle layer of both veins in digital measurement have inadequate character in separate parts of the wall. Especially in the portal vein system.

Thе unifiеd tесhniquе оf spеktrоfоtоmеtriсhеsky dеfinitiоn оf а аbасаvir in substаnсе аnd tаblеts diffеring in usе аs аn еxаmplе оf sulfоsаliсyliс асidсоmpаrisоn is dеvеlоpеd. Оptimum соnditiоns оf dеfinitiоn аrе prоvеd: а соmpаrisоn sоlutiоn сhоiсе, sоlvеnt – 0,1M hydrосhlоriс асid sоlutiоn, аnаlytiсаl wаvеlеngth – 297 nm. Thе rесаlсulаtiоn соеffiсiеnt is dеfinеd. Thе rеlаtivе stаndаrd dеviаtiоn оf thе dеvеlоpеd tесhniquе fоr substаnсе mаdе nо mоrе thаn 0,009, fоr tаblеts nо mоrе thаn 0,033.

Examined three groups of children aged 6 to 17 years: the first 96 children with CCLP (congenital cleft of lip and/or palate), the second 112 children with neuropsychiatric disorders (NPD) and the third (control) 86 somatically healthy children. On the basis of the index of KPU + kp and KPU in children with CCLP and in children with NPD high rates of prevalence and intensity of dental caries were found compared with the control group. The highest rates of prevalence of dental caries were found in children with CCLP and intensity of dental caries in children with NPD that is the most prominent in the children with NPD at the age from 6 to 12 years old. In children with CCLP and in children with NPD, the level of oral hygiene has significantly worse values compared to the control, which suggests the possibility of preventing tooth decay through improving oral hygiene of the mouth. The lowest level of oral hygiene was observed in children with CCLP that is mediated by severe congenital pathology.

In modern herniology tension free technic of hernia repair is a leading, thanks mainly to fewer recurrences. However, hernia repair breaks anatomy and functionality of the anterior abdominal wall, which leads to a deterioration in the quality of life of patients. Objective: To analyze the quality of life of patients after hernia repair ventral hernias. Materials and Methods: The analysis of the results of surgical treatment of 199 patients with ventral hernias after hernia repair in 6 months. For the study used questionnaires quality of life using the SF-36 form. Results: characteristics of each operation, positive and negative, are reflected in the indices of physical and mental health of the survey. Conclusions: onlay, inlay methods of hernia repair are characterized by the best indicators of physical health in the late postoperative period. Methods sublayplastics have a greater impact on the health of the patient in the postoperative period. However, mental health indicators surpass a simple hernia repair techniques.

With the help of biometric studies of the jaw models, 75 children with congenital blindness of the hard palate during the period of the bite of the milk teeth before and after the conducted orthodontic treatment studied the dynamics of changes in the individual sizes of the dental arches of the upper, lower jaw, and also the hard palate. The result of the orthodontic treatment with capping expanding devices on the upper jaw to uranoplasty was an increase in the frontal-retromolar and transverse dimensions of the dental arches between the dairy canines and molars, as well as the width of the hard palate at the level of the dairy canines and second molars. Changes in the parameters of the dental arches of the lower jaw, as well as the height of the hard palate, were statistically not reliable.

According to the results of immunological, biochemical studies of blood serum and oral fluid in 92 children with autoimmune diabetes mellitus in the period of the mixed occlusion investigated the cellular, humoral links of immunity and established the balance of bone metabolism at various stages of compensation endocrinopathy. Data were compared with similar parameters 48 children of I–II health groups. The obtained results allow asserting that with increasing severity of disease in children with autoimmune diabetes mellitus there is a significant weakening of the recovery processes of bone tissue, the development of local immunodeficiency, depression of cellular immunity in the presence of pronounced immunometabolic disorders.

The aim of our research is to determine ways of improving the results of surgical treatment of gastroduodenal ulcer bleeding. A promising trend is to be recognized a surgical strategy based on the prediction of recurrence of bleeding. The results of therapy of 2365 patients with bleeding-forming ulcers of gastroduodenal zone, who have been taking steady-nary treatment in MBHI KCC HEMC Krasnodar from 2009 till 2016 years. The have been analysed recurrence of bleeding effect in hospital was registered in 419 cases (17,7 %). The main criteria for the choice of tactics of treatment of gastroduodenal ulcer bleeding are: the degree of stability of the hemostasis of the ulcer, the severity of the bleeding and degree of the "operation risk". Additional criteria include: location, size of ulcers and the criteria for the violation of hemostasis. Differential approach based on the prediction of recurrence of bleeding, will help to improve treatment and reduce postoperative mortality in gastroduodenal bleeding.

The paper analyzes the data of appendicular infiltrate and chronic appendicitis based on CT and morphological studies. Identified by CT criteria, characterized by chronic inflammation process in patients with appendicular infiltrate. The comparative characteristic morphological changes in the appendix in acute and chronic inflammation. The correlation of clinical, morphological and CT criteria in the groops studied. Necessity of surgical treatement was determined.

Sorbtions and biological active compounds are perspective drugs for treatment of the purulent wounds. Results of the wound healing with phytomineralsorbent are shown in this article. Relative characteristic of phytomyneralsorbent and Dexpanthenol (Russia, Pharmstandard) was done on purulent injury of rat. Simulation of a purulent wound was applied to the area between the shoulder blades of Wistar rats. Infection was carried out with a hospital strain of Escherichia coli. Wound dressings were performed by the investigated agents in doses of 1 mg on injury of the animal during all phases of injury healing (21 days). Evaluation of the wound healing effect was performed on histological sections with early hematoxylin-eosin stained and dynamic of increasing wound surface. The wound defect of rats, which was treated by phytomineralsorbent, was significantly less than control in 2 times. The depth of necrosis in the inflammatory phase of the wound process was up to 0,85 microns deep, which is 1,7 times less than in control group. Using Dexpanthenol was characterized by a suppuration reaction and the presence of microbes. Thus, the use of phytomineral containing agents promotes a better healing of a purulent wound in the acute phase of the wound process.

Clinical and social efficiency of three different treatments of supporting therapy of Asthma of 102 patients at the age of 18–22 with moderately severe disease without concomitant pathology has been correlated in a prospective way. Observation over the patients has been carried out during a year. Minimal clinical efficiency was obvious when inhalation corticosteroids were selectively used. The patients receiving the combination of inhalation corticosteroids and beta – 2-adrenoagonists have completely comparable clinical effectiveness. Expenses on the taking of fixed combinations of mentioned medicines exceed expenditures on their wandering combinations.

Developed optimal conditions of quantitative analysis of tablets "Grandaxinum" and tablets "Fenazepam", using the method high-performance liquid chromatography. We used microcolony liquid chromatograph "milichrom A-02", condition analysis: gradient elution in the system lithium perchlorate, perchloric acid, water and acetonitrile, gradient linear 3700 mkl from 5 to 70 % at a flow rate of 100 mkl/min and a temperature of 40º C. Аs a standard substances were used pharmaceutical substance tofizopama and phenazepam. Conducted a validation assessment of the proposed conditions. The method is characterized by good linearity with the correlation coefficient at 0.9984 for tofizopama and 0,9991 for phenazepam in the concentration range of 0.025 – 0.5 mg/ml. the relative error of determination by the developed technique does not
exceed of 1.94 %.

Indexes of bone tissue mineral density of various sites of skeleton at 483 postmenopausal women depending on genotype of TNFSF11 gene rs9594738 (C>T) polymorphism were studied. It was established that women, who had CT and a TT genotypes in comparison with CC genotype owners were characterized by significantly lowered (Р<0,001 – P=0,026) densitometry indexes in zone of L1-L4 lumbar vertebrae, left and right proximal femoral departments, including left and right femoral necks, and also forearm bones distal department. Results of this research can be used for development of detection criteria of predisposition to postmenopausal osteoporosis onset and for increase of treatment-and-prophylactic actions effectiveness.

The objective of the research work is to study the influence of altered calcium homeostasis on the hemodynamic effects of zinc chloride. The experimental hypercalcaemiawas created in Wistar rats by intragastric administration of calcium chloride. Zinc chloride was administered intragastrically via a probe and subcutaneously, at a dose of 20 mg /kg daily for one month. At the end of the experiment the functional state of the cardiovascular system was investigated, the basic parameters of systemic hemodynamics were determined. The following parameters were determined: blood pressure – invasively (bloody way) by introducing a plastic catheter into the femoral artery. For measuring a minute volume of blood thermistor was inserted through the left common carotid artery to the aortic arch. Indications were recorded on the MX-04 monitor. Mean arterial pressure was calculated by a special formula, heart rate –by means of a surgical monitor; cardiac index, stroke index and the specific peripheral vascular resistance were calculated by special formulas. Studies have shown that in subcutaneous and intragastric administration changes in systemic hemodynamics in the form of hypertension was observed. In the experimental hypercalcaemia, induced by administration of calcium chloride, metal intragastric administration produced significantly less hypertensive reaction. In the group with subcutaneous administration of metal on the background of hypercalcaemia the changes were not pronounced.

The aim of the study was to determine the prevalence of chronic non- communicable diseases among glass fiber manufacturing workers to develop effective measures for the prevention. A total of 71 patients with occupational skin tumors were examined. Retrospective analysis of the medical records of these patients was performed. The results of the study showed that hyperkeratosis and skin cancer prevailed in the structure of occupational diseases. Priority concomitant chronic non-infectious disorders in workers with occupational skin tumors are diseases of the circulatory system. Multidirectional changes in a number of hematological parameters were found depending on the nosological form of occupational skin neoplasms. The results are the basis for the development of complex organizational and hygienic and medical preventive measures, aimed at maintaining the health of glass fiber manufacturing workers.

On the basis of a comprehensive study of the clinical and laboratory parameters of a comparative assessment of the effectiveness of operations subtotal hysterectomy with excision of muco-muscular cervical flap by using transvaginal mortsellyator and total hysterectomy about benign combined pathology of the cervix and uterine body. Depending on the extent of surgical treatment 2 groups of women were formed, who have had total hysterectomy and subtotal hysterectomy with excision of muco-muscular cervical flap by using transvaginal mortsellyator. As a result of further examination revealed the benefits of subtotal hysterectomy with excision of muco-muscular cervical flap: the duration of the operation, blood loss, and drop in hemoglobin levels after surgery. Preserving the anatomical relationship of the pelvic organ, saving ligament apparatus and cervical innervations save vaginal integrity, reduce the risk of complications in the form of descent and prolapse of the vaginal walls in the late postoperative period, which will undoubtedly improve the quality of life of women.

Сephalohematoma – one of the forms of birth trauma, which occurs in 1 % to 4 % according to different authors. It’s believed that cephalohematoma arises not only in obstructed labor, but in physiological childbirth too. Analysis of occurrence of cephalohematoma was held among 60 newborns. To decrease this pathology appointment of drugs, that affect blood clotting, must be more careful, and correction of complications of pregnancy and childbirth, must be in timely manner.

The authors analyzed the changes of functional and biochemical indices in young persons engaged in tube-casting plants and exposed to harmful physical and chemical factors. Some indices were deviated from their normal values 10–60 %. Signs of noise exposure to organs of hearing, disorders of hand-arm vibration sensitivity, retina angiopathy. Elevated IgE fraction, high oxidative stress, superoxidismutase activity reduction were revealed. The performed studies show a significance of functional and biochemical indices in young persons engaged in tube-casting plants since the indices reflect a development of preclinical pathologies which could lead to onset of occupational diseases in lack of proper preventive measures.

This article presents the organizacion of treatment for children with cerebral palsy with the botulinum toxin type A in large children’s therapeutic and prophylactic institutions in Krasnodar region. Such organization allows to cover the treatment of about 20 % of children with spastic forms of cerebral palsy, to ensure the purity of performance technique and to provide adequate rehabilitation.

44 students aged 18 to 21 years was estimated regulatory-adaptive status in the parameters of cardio-respiratory synchronism before and after the simulation of mental and emotional stress. On the dynamics of the regulatory-adaptive status was determined by the level of stress. For the simulation of stress used a sample from an arithmetic account, the deficit of time and distraction. All studied were divided by survey into two groups depending on the phase of the menstrual cycle. Each test before and after the test were evaluated regulatory-adaptive status. The subjects in the first (follicular) phase of the cycle made up the first group (27 students), and the second (luteal) – the second group (17 students). Most of the studied menstrual cycle was of 28-32 days. The obtained results show that in the second phase of the menstrual cycle the degree of stress was low, the index of the regulatory-adaptive status changed to 59.6 per cent in comparison with the original indicators. In the first phase was observed moderate degree of stress and the change in the index of the regulatory-adaptive status by 44.4 %.

Studied clinical – epidemiological features of current and the analysis of lethal cases at patients with cirrhoses of a liver various aetiologies owing to bleedings from varicose -the expanded veins of a gullet (VEVG) are studied. It is lead skrining the analysis of 310 cards of stationary supervision of patients with a cirrhoses of a liver various aetiologies and the retrospective analysis of 37 case records of patients died owing to a bleeding from VEVG, was on hospitalization in 2015 and 2016 in MBUZ KGK BSMP «Hospital of the first help». The group of risk is revealed at VEVG on a floor, age; the greatest degree VEVG at a bleeding, aetiologies a cirrhosis of a liver at a bleeding and indications for the emergency surgical help.

The aim of this work was to obtain data of the strength properties of structural ceramic materials used in the manufacture of non-metal constructions of dentures. As a method of ceramic processing was the selected method waterjet cutting. Was obtained for 10 samples Lacanau ceramic, hybrid and feldspatic ceramic. According to ISO 6872 conducted testing of samples for strength by the method of three-point bending. On the basis of your data we recommend that the materials exclusively for the manufacture of artificial crowns import and sale within the length of one tooth, such as inlays and veneers.

Retrospective analysis of the favorable course of pregnancy and childbirth of a woman with congenital pathology – achondroplasia. During pregnancy clinical and immunological studies, ultrasound scans, cardiotocography were held. Pregnancy ended by giving birth to a healthy newborn by caesarean section.

In recent decades, there is a trend towards growth and relatively high incidence of pancreatic cancer. Long-term results of surgical treatment remain unsatisfactory. However, in view of the progress of medical technology and the development of new surgical approaches to the treatment of pancreatic cancer, interest is the current state of the problem. This literature review focuses on the long-term outcomes of surgical treatment in patients with pancreatic cancer.

The review presents modern data on the pathogenic role of CC chemokine is CX3CL1 or fractalkine in the cascade of immune responses in various diseases. The material presented sistematizirovat the most significant results of the work of clinical diagnostic value fractalkine in pathological conditions. At the same time, in the literature very little information on clinical research studies of the content of chemokines in the serum in allergic skin diseases, the available data are inconsistent, and information about research of this kind in pediatric patients are not available. The authors draw attention to the possibility of using fractalkine as a marker of inflammatory activity and a prognostic factor for atopic dermatitis.

Over 1400 papers in foreign publications are dealing with the research of the biological activity of sodium dichloroacetate. Meanwhile in the domestic scientific literature the present review is the first one and has the purpose to unite and systematize the results of numerous studies of its effects in vitro on different cell lines and experimental models as well as on the whole organism with the broad spectrum of pathological conditions and disorders accompanied by the mitochondrial dysfunction. The mechanism of its effect is connected with the activation of the pyruvatdehydrogenase complex that causes the optimization of the oxygen consumption and the decrease in the acidification level of environment in normal cells in conditions of the tissue hypoxemia which enables us to label it as a metabolic cytoprotector. In atypical cells the result is present as the metabolic inversion with the intensification of free-radical processes as well as the activation of the caspase enzyme cascade, the activity decrease of proproliferative and proangiogenetic transcriptional factors which explains the positive effect in treatment of a whole number of tumours.