The article presents the results of the survey dentists on problems of endodontic treatment of teeth. The data obtained indicate a low level of knowledge of doctors, the use of inappropriate methods and materials for obturation of root canals. Lack of awareness of physicians, as well as extremely poor knowledge of anatomy of the maxillofacial region, casts doubt on the quality of education and requires a major adjustment curriculum as students and postgraduate level, including training cycles.

A correlation analysis to identify the relationship between markers of endothelial dysfunction (coefficient of endothelial function - EFC, type C natriuretic peptide, endothelin-1) and indicators reflecting the activity of inflammation (C - reactive protein, fractalkine) in patients with chronic obstructive pulmonary disease (COPD), bronchial asthma (BA), coronary heart disease (CHD), arterial hypertension (AH) and in patients with comorbidity (COPD+CHD, COPD+AH, BA+ CHD, BA+AH). It was revealed that at comorbid combinations COPD+AG, BA+AG basic mechanism of development of endothelial dysfunction is the activation of chemotactic inflammatory cascade with hyperproduction of fractalkine. C-reactive protein, fractalkine are diagnostic and prognostic markers defeat of endothelium in patients with combinations of COPD+ CHD, BA+CHD.

Depending on the nature of proliferative processes morphological forms isolated uterine fibroids: a simple and proliferating. Based on the study results of the morphological structure of fibroids received in the surgical treatment of patients of reproductive age was a retrospective analysis of sonographic parameters. Identifies parameters with the greatest diagnostic and prognostic value. Based on the data obtained mathematical model was developed that allows high sensitivity and specificity to determine the morphological type of uterine fibroids. That has been proven in a prospective study.

The aim of this work was studying of monocytes and granulocytes lipopolysaccharide (LPS)-connecting potential at Grave’s disease patients with various response type on endotoxin in interrelation with C(-159)T polymorphism of CD14 monocytes receptors. The antiendotoxin Ig G (anti-ET-IgG) blood concentrations were studied by ELISA for subdivided group patients according antibodies response to ET. The monocytes and granulocytes LPS-connecting potential were assessed by laser double staining flow cytometry. Genetic polymorphism defined by PCR. All patients with GD were divided into three groups. 1st group included 30 patients ET antibodies hyper- and normoresponders with CC allele combination; the 2nd group was made by 36 patients ET antibodies hyper- and normoresponders with pathological T allele; the 3d group included all ET antibodies hyporesponders (21 patients) who had pathological T allele. 33 healthy donors were investigated too. It was revealed that the monocytes and granulocytes LPS-connecting potential in the group normo-, hyper-and hyporesponders with a genotype, which contains T alel were higher than in group of patients without a mutation and in group of control. Thus patients with hyporesponder response, being combined with a genotype containing T alel in 159 positions of a gene of CD14 receptor, are more predisposed to endotoxin's pathological action.

On laboratory animals receded experimental model of hyperthyroidism. Work carded out on 46 white male rats of Wistar weighing 250-300 g. Laboratory animals administered daily L-thyroxine in a dose of 1,6 mg per 1 kg of body weight. Rats were taken out of the experience through 7, 14, 21, 28, 45, 60 and 90 days. To determine the level of thyroid hormone blood sampling was carried out from tail vein. Conducted macroscopic and microscopic examination of the liver. The experimental results showed that the daily administration of L-thyroxine observed increase in the level of thyroid hormones (T4, T3) in the blood and a decrease in thyroid stimulating hormone (TSH). Histological examination of the liver revealed diffuse hydropic and ballooning degeneration of hepatocytes, colliquative necrosis areas with the formation of cavities, diffuse perisinusoidal edema, lymphocytic infiltration. When stained with nitro acid silver identified nucleolar organizers. Marked increase in the number of nucleolar organizer regions in experimental thyrotoxicosis on the 28th day and the gradual reduction of the end of the experiment.

Mercury and cadmium poisoning leads to the development of a powerful oxidative stress was associated with increased concentrations of malondialdehyde and hydroperoxide. These changes combined with a decrease in catalase activity, indicating that inhibition of the action of the antioxidant defense mechanisms of the system. Application melaxen in chronic intoxication with heavy metal salts, has a pronounced antioxidant effect, which leads to a reduction of lipid peroxidation and the simultaneous increase in the activity of catalase.

Direct stimulation of the growth potential of orthodontic upper jaw during all periods of the formation of occlusion in children with unilateral cross-cutting cleft lip and palate makes it possible to restore the size and shape of the dental arches during the mixed dentition and to ensure stability of the results of complex treatment. Multi-faceted approach to the rehabilitation of children with orthodontic cleft lip and palate considering genetic determination to reduce dentoalveolar deformations due to congenital anomalies and surgical interventions.

The method of bacteriologic investigation employing the anaerobic cultivation technique, as well as the molecular-genetic method based on polymerase chain reaction, were used to detect the major parodontopathogenic species and to conduct quantitative evaluation of parodontopathogenic and residential microflora in gingival sulcus biofilm in children and adolescents (aged 7-14) with dentoalveolar anomalies. It has been shown that a proper indicator best reflecting the intensity of morphological and functional disturbances in case of dentoalveolar anomalies in children and adolescents, is an increase of parodontopathogene genetic markers in gingival fluid (Porphyromonas gingivalis, Actinobacillus actinomycetemcomitans, and Bacteroides forsythus).

The study involved 30 patients (25 females, 5 males) aged 34 to 55 years with a confirmed diagnosis of hypothyroidism, mean age 43,5 years, disease duration ranged from 1 year to 15 years (study group). TSH ranged from 5,15-99,27 mME/L (27,26±4,20 mME/L). In the blood of patients found to decrease the activity of catalase 2-2,5 times (p <0,05), SOD activity of superoxide dismutase (SOD) by 18-19%, the level of free SH-groups of erythrocytes and plasma total antioxidant activity by 2-2,5 times (p < 0,05). Maximum flash of chemiluminescence level average values, and area flash of chemiluminescence and TBA-active products as thiobarbituric number was higher in the control group 4, 3,3 and 3.1 times, respectively (p <0,05). TNF-alpha had mean values of 8,41±0,6 pg/ml, which is 40,2% higher than the upper limit reference values (0-6 pg/ml) and 150,3% higher than the average values of control group, IL-8 averaged 20,27±0,2 pg/ ml, which is 2 times the upper limit of the referent (0-10 pg/ml) and 3,5 times higher than the average values of the control group and IL-10 have average values 3,38±0,3 pg/ml, which corresponds to referent values (0-20 pg/ml), but less than 2,6 times the average values of the control group of healthy donors.

Carrying of a pregnancy in women with obesity is still actual at present. it is especially important during the realization of extracorporal fertilization. implementation of well-founded pregravidal preparation, intended for normalization of hormonal, biochemical tests and carbohydrate metabolism, promotes increasing the rate onset of pregnancy and it's carrying.

43 patients (9 male and 34 female) with diabetes mellitus of the second type with clinical hyperthyroidism at the age of 45-60 (the average age is 52,47±5,57 years) have been examined with the aim of studying the dependence between the thickness of intima-media complex of a common carotid artery and the level of expression of soluble adhesion molecules sICAM-1 and sVCAM-1. Statistically reliable correlation between the thickness of intima-media complex of a common carotid artery and the level of adhesion molecules sICAM-1 and sVCAM-1 (р<0,05) has been investigated. The obtained results show that the risk of cardio-vascular diseases is high for patients with diabetes mellitus of the second type with clinical hyperthyroidism and timely active preventive measures against atherosclerosis should be taken.

The article presents the clinical- differentiated criteria for selection of patients with borderline mental disorders related to the diagnostic category of ICD-10 F4 «Neurotic and somatoform disorders» for targeted comprehensive study of the quality of their lives based on nosology. Statistically represented diagnostic group in an amount of 402 's of patients in both absolute and percentages with regard to their place of residence and sex : rural - 143 (35,6%), including 43 men (30,1%), 100 women (69,9%), urban patients - 259 (64,4%), including men - 71 (27,4%), women - 188 (72,6%). Presented sample of patients with borderline mental disorders will be subject to the system analysis to identify demographic and health, socio-economic, professional production, and other factors that adversely affect the quality of life, with the development of recommendations to address them.

The prevalence of incidence and mortality from a bladder cancer in Krasnodar region during 2003-2012 was studied in this article on the basis of documents. The analysis of spatial distribution of incidence and mortality frequency from a bladder cancer on 44 municipalities of Krasnodar region is carried out by means of mapping and risk zones of bladder cancer cases are allocated. Recommendations about preventive actions carrying out in these zones are presented here.

A comparative analysis was carried out concerning the state of the system «lipid peroxidation - antioxidant protection» (POL-AOP) in mixed saliva of patients with chronic periodontitis of mild (n = 22), moderate (n = 20) and severe (n = 18) form at the background of hypothyroidism. As a result of the research it was found that at the background of hypothyroidism there develops an imbalance in the work of all parts of the local system of nonspecific defense of the body, especially at severe periodontitis. And reduction of key enzymes of the antiradical protection (superoxide dismutase and catalase) in mixed saliva is the leading biochemical change that is accompanied by increased inflammation in the periodontium. It is shown that the adaptation increase and AOP therapeutic effect in the shortest term after the use of mexidol is manifested by reducing lipid peroxidation processes, especially in patients with mild periodontitis. Effectiveness of the treatment of moderate and severe periodontitis using mexidol was significantly lower, in comparative aspect.

Article evaluates the influence of vitrectomy on the state of free radical oxidation and antioxidant protection in tissues of the eye. Attention is paid to the study of the role of free radical reactions during vitectomy. Despite the great progress that has been made over the past decade in understanding the molecular mechanisms of the development of vitreoretinal pathologe development of preventive measures to prevent the degenerative changes of the vitreous is in the very beginning of the development. Therefore the diverse, including pilot studies will help to expand our knowledge of the biochemical changes occuring and help to develop optimal preventive measures.

The pharmacoepidemiological study includes a review of the use of lipid-lowering drugs with the main indicators of consumption - defined daily dose (DDD) and prescribed daily dose (PDD). Pharmacoepidemiological analysis revealed that the pharmacotherapy of ischemic heart disease in a sample of patients studied mainly prescribers Tulip (atorvastatin) at daily doses of 10 and 20 mg, as well Atoris (atorvastatin) in a daily dose of 10 mg. The total cost of lipid-lowering therapy in 660 patients with ischemic heart disease in 2009-2010 amounted to 440,1 thousand rubles. Applied consumption indicators showed that the maximum DDD - at tulip, PDD - at simgal and simvakard. The maximum value of DDD - at tulip, PDD - at zocor.

The article presented the results of histological study of bioptates that were taken from different parts of gastrointestinal tract of 111 patients. The material was investigated after staining of the sections by means of histological methods that usually used for mucin selected revealing. The study demonstrated the histochemical and immunological marks of metaplasia transformation in dysplasia and adenocarcinoma for the esophagus, the stomach and the colon.

Russian Federation and Ukraine have various regulatory legal acts governing the registration of infectious and parasitic diseases and epidemiological surveillance in general. Due to adoption of the health standards of Russian Federation in Republic of Crimea in 2015, we can expect the increase of infectious and parasitic diseases in some nosology. But this process cannot be associated with worsening the epidemiological situation in Crimea; it may be the result of improving the quality of clinical, laboratory and epidemiological diagnosis. Accession the new region to the Russian Federation and the associated change in the health care system can provide valuable information that compares performance of selected elements of the two systems and use the data to improve them.

The article presents the results of the treatment of patients suffering from temporomandibular joint dysfunction with the use of the newly developed method of puncture vacuum-darsonvalization. Comprehensive treatment received 66 patients of 2 clinical groups. Objective evaluation of clinical data, as well as the dynamics of the recovery of the TMJ function were made based on the analysis of survey data, clinical examination and study of objective research methods developed by us with the inclusion of prognostic signs. The aim of the study was to improve the results of treatment of patients with TMJ disorder by analyzing prognostic markers and use of individual dental splints with puncture using vacuum-darsonvalization. The results of applied treatments of TMJ disfunctions using developed method of puncture vacuum-darsonvalization showed to be the most effective, allowing to obtain 97.1% of good results in long-term period.

The structure of mental disorders at recruits of the city of Krasnodar from 2011 to 2013 years is studied; comparison with Krasnodar region is carried out. Organic mental disorders prevail (59,4%), the second place is taken by personality disorder (18,0%), the third place is taken by mental retardation (8,3%). Timely identification and treatment of mental disorders causes low level of mental pathology among the persons exempted from an appeal on military service.

This article is devoted to correction of mineral density of bone (BMD) tissue by alphacalcidol (Alphadol-Ca) in patients with diseases of the gastrointestinal tract with osteopenic syndrome. It was shown a positive influence on the regulation of Ca²⁺ exchangeandbone mineralization.

Comparative assessment of cytokine profile status in aqueous chamber moisture with experimental rabbits while use of traditional suture material and nickelid titanium monolithic fibers with penetrating wounds of eye cornea has been done. It has been approved within the course of examinations (3, 7, 30 days) that use of conventional suture material does not influence on FNOα concentration; concentration of IL1β is certainly increases from the 3rd day of examinations and remains unchanged up to the end of monitoring; IL2 concentration probably significant increases to the 30th day of examination and concentration of IL10 increased in early period (on the 3rd day), is declining to the same level with noninvolved animals. in any period of examinations after suturing of eye cornea with nickelid titanium monolithic fibers of rabbits in experimental group, level of IL2, IL10, FNOα was fixed on the reference value level, except of obvious reduction of the latter (IL10, FNOα) in early periods of monitoring (3rd day). Herewith, certainly increased IL1β concentration that was studied dynamically, was less expressed compared to that appeared while use of conventional suture materials with postoperative rabbits. Analysis of the obtained data generally grounds advisability and preferable ness of use of suture material of nickelid titanium in cases of penetrating eye cornea wounds that has been confirmed by clinical data in this experiment.

Analysis of surgical treatment of 106 patients with ulcerative gastroduodenal hemorrhage arising in the presence of pyloroduodenal stenosis of varying severity. The patients were divided into 2 groups: 50 people, made a comparison group received traditional surgical treatment, and 56 people. A group of patients who received surgical treatment developed. It is shown that the application of a rational preoperative surgicaltion election tactics and postoperative therapy with the introduction of oxygen-containing solution intraenteric improve treatment outcomes.

Assessing the microvasculature (MV) in patients with arterial hypertension (AH) compared to the relatively healthy volunteers and in patients with different severity level kidney disease, by determining parameters of capillary blood flow using Doppler ultrasonic. 326 people examined, 34 of them were relatively healthy volunteers, 144 patients with hypertension, 148 patients with hypertension and concomitant renal disease. It is revealed that relatively healthy volunteers have normal microvasculature reaction in response to the test with an external action (cold test and reactive hyperemia test), and in patients with arterial hypertension this reaction is disrupted and appears as a slow and inadequate response of the microvasculature to stimuli. The comparison of the microvasculature in persons with normal and reduced GFR obtained that decreased GFR is accompanied by a deterioration in microcirculation both at rest and during functional tests. This can be used as a preclinical marker of kidney damage in hypertensive patients along with the calculated GFR.

The study of angiogenesis factors in patients with cardiovascular disease by determining the plasma concentration of endostatin and vascular growth factor (VEGF). 82 patients with cardiovascular disease (CVD) and 19 healthy volunteers were examined. Revealed that the level of endostatin is reliably higher among patients with high blood pressure (BP) than in relatively healthy persons. Established that the maximum values of VEGF were in patients with arterial hypertension (AH) and acute coronary syndrome (ACS) in history. The VEGF level was reliably lower in patients with hypertension only persons. Maximum values of endostatin were observed in patients who had undergone ACS.

In LLC «Health» examined 45 patients with inflammatory diseases of the pelvic organs and a confirmed diagnosis of «chronic endometritis». Age ranged from 21 to 39 years. All were randomly divided into two groups: control and basic. Following the examination of the control group patients underwent combined therapy based on the detected pathogens, followed by hormonal correction, and patients of the main group was assigned a combined therapy: integrated treatment with local injection of drugs into the uterus and pelvic organs with subsequent hormonal correction. After the regular menses in most patients in the control group experienced a relapse, and patients of the main group in 48% of cases observed recovery of reproductive function.

We investigated the intensity of barium sulfate stimulated luminol-dependent chemiluminescence (SLCL) blood after pre-incubation of blood samples with food dye tartrazine used at different concentrations in healthy donors and patients with asthmatic triad combined with tartrazine intolerance. Significant differences indicators SLCL blood from healthy donors and patients with intolerance to this dye allows us to use chemiluminescence method for the diagnosis of tartrazin intolerance.

This article presents the results of a survey of 40 women with physiological pregnancy cesarean delivery at the age of 21-40 years and 12 non-pregnant women. The level of content of adiponectin, resistin, insulin and glucose levels in the blood plasma by ELISA. Calculated BMI and HOMA-IR. The study found that multiparous women develop more severe insulin resistance, characterized by increasing levels of insulin, glucose, HOMA-IR compared with nulliparous. However, pregnancy is characterized by physiological changes in endocrine activity of adipose tissue, expressed in decreased level of adiponectin and resistin concentration is increased.

The study included 45 patients (90 eyes) with ocular surface changes type of dry eye syndrome, etiological prerequisite for the observed was a combination of chronic blepharitis infectious etiology phenomena dysfunction meybomian glands and chronic eye ischemic syndrome. Patients of the main group in addition to tear replacement therapy was performed non-invasive ultraviolet irradiation device «Ecosvet-1», therapeutic effect which is due to its anti-inflammatory and scalp-stimulating effect, as well as the ability to improve the state of the microcirculation of tear production organ. The device enables to achieve a more pronounced eliminating subjective symptoms, functional and objective evidence of the disease than isolated tear replacement therapy, and reduce the instillation of the preparation of artificial tears during the day.

A case of the patient 69-years with ichthyosis vulgaris, seborrheic keratosis and warts is described. Supervision by interestingly atypical picture of hereditary dermatosis at the patient with insulin resistance that can be considered as a provocative factor of development seborrheic keratosis and warts.

Usually old persons get sick such disease as hairy cell leukemia. However, case of adolescent disease by hairy cell leukemia has registered recently. The article is devoted to this case and describes methods of diagnosis and treatment.