The results of surgical treatment of 171 patients with infected pancreonecrosis. It was established that mini-invasive treatment under ultrasound gives the best results when pankreonekroticheskih abscesses and phlegmon containing predominantly liquid pus. In the presence of large seizures should perform cross-omento bursostomu.

This article is devoted to the search for new cyclic guanidine derivatives with hypoglycemic activity by means of in silico methods. The results of computer prediction of hypoglycemic effect for nine classes of these compounds were analyzed. Two perspective classes of cyclic guanidine derivatives have been identified. Planning in silico screening was performed and new unstudied substances were tested.

The purpose of this paper - to investigate the relationship of low levels of bilirubin (BR) with lipid profile and blood antioxidant status in men with coronary heart disease. Our research has shown that low levels of bilirubin is associated with atherogenic changes in lipid profile and decrease its antioxidant activity. In clinical practice, bilirubin can be used as an indicator of antioxidant status of the organism.

The article provides information about habits of the routes to the proximal humeral for people with different constitution. The clinical studies were made on 55 corpses, which were put in order of constitution, body mass and shoulder-elbow length. Results of studies have shown us that for people with normal body mass better to use anterior approach in a case of fracture with breaking of the proximal humerus, transdeltoid rout for people with transvers fractures of collum and low bone mineral density. As for people with subnormal body an anterior approach is more convenient than transdeltoid rout, and for patients with overweight and lipotrophy of the I degree selection of the rout depends on character of the fracture and optimal method of the osteosynthesis.

Direct stimulation of the growth potential of orthodontic upper jaw during all periods of the formation of occlusion in children with unilateral cross-cutting cleft lip and palate makes it possible to restore the size and shape of the dental arches during the mixed dentition and to ensure stability of the results of complex treatment. Multi-faceted approach to the rehabilitation of children with orthodontic cleft lip and palate considering to reduce dentoalveolar deformations due to congenital anomalies and surgical interventions.

Actual problems is correlation between the level of stress resistance and testosterone concentration in a blood was set: the more testosterone within normal limits, the higher is level of stress resistance. In 42 healthy men aged 25-40 years was identified testosterone concentration in a blood by metods electrochemiluminescence. The level of stress resistance was assessed by changes regulatory-adaptive status. The last was identified by filter samples cardio-respiratory synchronism in the initial state and the action of stress factor (arithmetic test score under time). The subject with an excellent regulatoryadaptive ability of the body and a decrease of 5-6% or less in their regulatory-adaptive state were included in the high level of stress resistance. The subjects with a 50% decrease in index regulatory-adaptive state in response to stress were included in the moderate stress resistance group. A decrease in index regulatory-adaptive state by more than 50% was the evidence of low stress resistance. It was that, hearing level stress resistance - testosterone concentration in a blood 8,38±0,12 ng/ml; moderate level stress resistance - testosterone concentration in a blood 5,73±0,04 ng/ml; low level stress resistance - testosterone concentration in a blood 3,64±0,04 ng/ml. The evaluation of stress according to previously conducted analysis of the testosterone concentration at inspection allows us to characterize the willingness of men to stress tolerance was shown and it may be included in the set of tests to recruit people in extreme professions.

The article presents the results of applying a combination of two antimicrobial agents for medical treatment and filling of root canals of teeth with periodontitis. A study of the nature of the microflora of root canals in 128 patients aged 25 to 54 years. In the treatment of periodontitis used a combination of trimethoprim/sulfamethoxazole (TMP/QMS) and its combination with metronidazole. Analysis of clinical observations have shown that the use of TDM/QMS and its combination with metronidazole in the treatment of periodontitis has a positive effect for 88,7% of patients.

It was carried out detailed clinical and follow-up examination of 347 patients of youthful age (16-25 years), with the episodic type of schizophrenia (F20 in ICD-10), hospitalized with manifest psychotic attacks in clinic of MHRC of the RAMS during the period from 2000 to 2013. A number of the key provisions, allowing to structure approaches to the organization and carrying out therapeutic actions at patients with first attacks of the youthful schizophrenia was formulated. The main tactics of purpose of antipsychotic therapy at various stages of a course of schizophrenia was described, besides, need of use of methods of mental correction and social rehabilitation as a part of complex treatment of patients of youthful age was proved.

In article results intraoperational researches sewed up perforation ulcers are described, the basic pathoanatomical structures above a stenosis parts of a duodenal gut and gastroduodenal transition are designated. The received data about pathomorphology sewed up ulcers testify to their huge morphological variety, necessity of an individual approach for surgical treatment sewed up perforation ulcers.

The study demonstrated that eight weeks after ovariectomy in female white Wistar rats endothelial dysfunction of bone microvasculature and deterioration of regional blood flow in bone develops, leading to the emergence of generalized osteoporosis. Nanoparticulated forms of losartan and resveratrol, possessing endothelioprotective action, effectively prevents the reduction of regional microcirculation in bone tissue, keeping it at the level of intact rats. It is allowed to maintain an adequate level of bone remodeling processes, which manifested in slowing of the thinning of bone trabeculae and preventing the occurrence of their microfractures.

The article presents the results of sociological research conducted by in which to analyze the level of satisfaction of their professional activities ophthalmologists state public health institutions and private health organizations of the city of Stavropol, rendering medical services in ophthalmological. Comparative analysis can identify problems, trends and main directions in enhancing the effectiveness and improving the organization of ophthalmic services.

Knowledge of the impact of dentures on abutment teeth and alveolar ridge to optimize the process of selecting the type of prosthesis, which in turn will improve the quality of life of patients in situations of border defects of the dentition.

As a result of the research it was revealed that pregnant women with bacterial vaginosis change indicators immunologists, feto-placental complex, leading to complications of pregnancy, development of hypoxia, intrauterine infection, high maternal and perinatal morbidity.

Significant development of the heart transplantation in clinical practice allowed implementing these types of surgery in most of the major cardiac clinics in the world. This happened because of the improvement of surgical techniques, artificial blood-circulation apparatuses and especially immunosuppression methods. It goes without saying, that these achievements raise the new questions. One of the most important one among them is the recovery of extracardiac regulation, especially the nerve regulatory effect on the transplanted heart. Six months after surgery we've examined 10 patients. Cardiorespiratory synchronism was not detected among all the patients, primary pacemaker in the sinoatrial region of the heart showed no reaction to the Danini-Aschner reflex. These facts showed no signs of the heart's functional reinnervation and recovery of mechanisms of the heart rhythmogenesis hierarchical organization. At the same time, changes in heart rate variability of these patients gave us the reason to assume a manifestation of the initial stages of incorporating the central nervous system influences to the heart rate. The spectral analysis of heart rate variability among these patients showed that TP ms² they amounted 152,45 ± 13,48; HF ms² - 59,85 ± 25,02 and VLF ms² - 74,55 ± 33,16.

In order to improve the existing incremental principle of determining the cardiac and respiratory rhythm synchronization (CRS) range the 'quick technique' of determining the index of regulatory-adaptive status (IRAS) of the human body has been proposed. In order to reduce the number of samples we proposed to apply the statistical forecast of regulatory and adaptive status (RAS) (from 'high' to 'low') on the basis of its least-consuming measurements or by fixing the CRS parameters. The following factors/arguments have been examined as the basis of the forecast: the minimum boundary of the synchronization range, duration of evolution synchronization at the minimum boundary, the following categories also have been taken into account: initial respiratory rate, initial heart rate, age, height, weight, gender, menstrual cycle phase, diastolic and systolic blood pressure values. Linear discriminant analysis and neural network (NN) classification techniques - multilayer perceptron and network of radial basis function type have been analyzed. Neural network classification has shown the best accuracy. Assessment of accuracy and confidence level of the forecast has been performed. On the basis of the NN-classification RAS level has been proposed curtailed incremental definition of IRAS technique: possible to complete the examination in 1 stage (probability 70%), 2 stages (probability 90%), or 3 (control) stages (samples), it is depending on the subject's observed RAS level.

This study analyses the changes of the cardiovascular system organs of 254 patients with stage 2 hypertension, 1-2 grade combined with rheumatoid arthritis (RA) in the initial state. After screening and obtaining written informed consent, the patients were divided into two groups: group 1 consisted of 142 patients in the stage of remission with both clinical and laboratory features, group 2 included 112 patients with severe symptoms (flare-ups). Myocardial structural changes exhibited by both groups of patients correspond with the common development of left ventricular (LV) hypertrophy, the increase in absolute and relative values of the morphometric parameters. Identified correlation confirms the negative impact of the degree of activity of RA on renal function, indicating a higher risk of cardiovascular complications in this group of patients.

30 patients with periodontitis have been involved in identification of index of regulatory-adaptive capacity status prior to treatment and after it, and from it they have determined regulatory-adaptive capacity of organisms. The more severe pain was the less regulatory-adaptive capacity of human body was. Regulatory-adaptive capacity has increased after remove of pain by treatment of periodontitis. Consequently, regulatory-adaptive capacity of organism can serve as an index for periodintitis treatment efficiency.

The article presents the results of experimental studies on the activity of acid lysosomal field of glycosidase inhibition (β-glucuronidase, β-glucosidase and β-N-acetylglucosaminidase) and their influence on the function of cells of the pulp in the conditions pulphyperthermia. Experimental study was conducted in 6 mongrel dogs. It is established that the temperature factor odontophoridae influences the activity of the acidic lysosomal field of glycosidase inhibition, significantly worsening the conditions for the functioning of the cells of the pulp of the tooth, which necessitates the use of activators zingiberone field of glycosidase inhibition and inhibitors aktivirovat field of glycosidase inhibition of dental pulp after odontophoridae.

The article presents an assessment of the effectiveness of the use of tea tree essential oil in therapy of patients with chronic gingivitis. The study involved 43 people who underwent clinical and laboratory examination. It has been determined that the use of tea tree essential oil in the treatment of patients with chronic gingivitis reduces the duration of therapy, the effectiveness of the rehabilitation of patients, which was significantly confirmed by the data as a clinical and laboratory examinations.

Surveyed 29 people aged 20-25 years, 19 of which have a insufficient of magnesium, osteoarticular symptoms undifferentiated dysplasia оf connective tissue, who have been diagnosed with insufficient of magnesium and 10 practically healthy persons. All surveyed were divided into 2 groups: the first group consisted of 19 people, and the second 10. Evaluation of quality of life (QOL) and its comparison groups. The marked decline in the quality of life in the group 1 compared to group 2 on a range of indicators (role functioning, pain, general health, vitality, physical health component).

Were studied reproductive health of 200 women aged from 18 to 48 years, of which 64 with fibroids, 33 - with fibroids in combination with adenomyosis and 103 - without fibroids and adenomyosis. Performed genotyping of six molecular genetic markers (SNPs-351A/G and -397 T/S ESRa gene, a polymorphic marker genes of tumor necrosis factor a receptor tumor necrosis factor 1-St and 2-nd type and lymphotoxin a) to study the role of family history in the formation of fibroids in the uterus in women. Women with genotypes GG, GA, AA polymorphism +36 A/G receptor tumor necrosis factor 1 and type GG polymorphism +250 G/A lymphotoxin a are increased risk of developing uterine fibroids and adenomyosis.

There is a complete range of services to patients with gynecological diseases at the stage of outpatient medical care is available. The article discusses the results of the assessment of problems and prospects of medical care provided to patients at the outpatient stage, by doctors of women's health clinics and their patients.

In this work comparative evaluation between the degree of the decrease of visual acuity and the data of morphometric research of the macular area (thickness of the central area of retina and the volume of the macular area) with the patients with macular edema developed against the backdrop of thrombosis of top temple branch of the central vein of retina was made. The data received make it possible to And the tactics of the future treatment and prophylaxis therapy of the patients with post-thrombotic retinopathy.

Surgical treatment is carried out 1998 patients with urgently complications of a cancer of a thick gut which during the period from 2001 to 2011 were treated in hospitals of Smolensk and the Smolensk region. Intestinal obstruction was observed in 1644 cases (82,3%), perforation of a tumor 208 (10,4%), bleeding of 146 (7,3%) (n = 146). From among all operated patients radical operations are executed at patients 1427 (71,4%). Radical surgery was carried out by the patient of advanced and senile age less than at persons of younger age. At men with the complicated cancer of a thick gut the bigger percent of radical operations in comparison with women is noted. Besides, the volume, and nature of operation depended on hospitalization terms from the moment of development of complication, weight of the general state, prevalence of malignant process and existence of the remote metastases.

The article represents the study results of regular adaptive possibilities in patients with (generalized anxiety disorder) GAD. The patients were divided into 3 groups according to the Hamilton anxiety scale. Patients with mild and moderate levels of anxiety had satisfactory regular adaptive possibilities, and bad possibilities in case of severe anxiety. Assessment of regular adaptive status reflects the severity of GAD.

On the basis of the study, 20 patients with chronic generalized periodontitis of moderate severity, 20 patients with single fractures in the body of the mandible and 20 volunteers with intact periodontium developed a new immunological indicator to differentiate between acute dental process from chronic and very dynamics of transformation, which adequately reflects the seriousness of the disease and effectiveness of treatment.

Based on the timing, material costs, depreciation of equipment, as well as the wages of doctors and nurses in accordance with the Presidential Decree of 7.05.2012 № 597 «On measures for implementation of the state social policy» calculated cost price of modern methods of treatment and prevention of dental diseases.

In this article offered a case of surgical treatment of recurrent varicose veins. The operation described in detail. We present short-term and long-term results. In this report clearly reflects the efficiency of the correction valve of femoral vein for recurrent varicose veins.

This article presents a literature review of today's challenging clinical problem of mental disorders in endocrinopathy. After an introduction to the topic describes a brief history of the development of psychoendocrinology and putative mechanisms of the pathogenesis of mental disorders caused by endocrine dysfunction. Outlines the main clinical forms of mental disorders, as well as analyzes the patterns of their clinical dynamics. Marked clinical manifestations caused by a non-specific impact of endocrine dysfunction, as well as the specific features of each individual endocrinopathy. In conclusion, describes an integrated approach for the treatment and rehabilitation of patients with these forms of pathology. Given the prevalence of endocrinopathies and frequent combinations thereof with mental disorders information on this issue is needed for professional doctors of all specialties.