The analysis of 127 patients with peptic ulcer disease and simultaneous combination of several complications (bleeding, perforation, stenosis, penetration). A method for determining the assessment of blood loss. The correlation analysis of the proposed method with the definition of VCB with Evans Blue. The correlation coefficient - 0,87. The high degree of correlation between the studied traits and bcc, Evans determined by the way we can recommend the proposed methodology for broad application in practice. It is important that the proposed signs to determine the severity of bleeding informative, do not require special equipment, it is easy to carry out at any time of the day repeatedly. Substantiates the surgeon during the tactics combined complications peptic ulcer.

It was presented that the indole SS-68 derivative (10^-6 and 10^-5 М) revealed the manifested antianginal action as well as the antiarrhythmic one in experiments on rats' isolated heart, at the same time it had no considerable influence on the contractile myocardium function by the normal perfusion level. The loss of coronary vascular resistance under the influence of SS-68 was considerably restrained by glibenclamid, the blocker of ATP-sensitive K⁺-ducts (I_KATP). The received data allowed us supposing the presence of I_KATP incitant properties in SS-68.

In this study linear and three-dimensional left ventricle characteristic de-pending on the level of C-terminal telopeptide of type I collagen of 112 ischemic chronic heart failure patients with preserved and reduced systolic function have been studied and analyzed. The dynamics of the main clinical symptoms, indicators of structural and functional heart status according doppler-echokardioskopy and the level of C-terminal telopeptide of type I collagen were evaluated. As a result of this work we revealed a connection between interstitial type I collagen degradation process and remodeling of the left ventricle in patients with chronic heart failure.

The article describes the experience of endoscopic ligation of esophageal varices in 338 patients with liver cirrhosis with portal hypertension from 2009 to 2016. In this paper we analyzed the stages of endoscopic ligation, ligated number of nodes in each patient, the effectiveness of ligation causes of failures.

There are proponents and opponents the theory of relation arterial and venous thrombosis. To clarify the relationship between adverse cardiovascular events and venous thromboembolism 1316 died persons autopsy reports were studied from 2009 to 2014. Arterial thrombotic were found in 375 people. The total number of deaths from venous thromboembolism (VTE) amounted to 178 patients, and the patients with arterial thrombosis frequency of VTE was 10 %. Patients with coronary, brachiocephalic and peripheral arterial thrombosis had an increased likelihood of VTE (OR, respectively, 32; 1,9; 1,4). The medical history of thrombotic events was studied, the frequency of VTE among them was also higher. Components of the metabolic syndrome should be called among the factors of VTE risk.

The search for new drugs have prekonditsioniruyuschimi properties is a promising direction of modern pharmacology. We investigated the role of prekonditsioniruyuschih properties of resveratrol and nicorandil in the correction of ADMA-like pre-eclampsia. Keeping resveratrol (2 mg/kg) and nicorandil (2x10 mg/kg) led to a marked correction of morphological and functional disorders arise in modeling experimental preeclampsia. Concomitant administration of a blocker of K⁺ ATP-channels -glibenclamide (50 mg/kg) with the test drugs practically eliminate protective effects of resveratrol and nicorandil. These data suggest a significant role prekonditsioniruyuschih properties of resveratrol and nicorandil in the implementation of the positive effects of the correction of morphological and functional disorders arise when modeling ADMA-like pre-eclampsia.

Currently, the question remains as to the appropriateness of percutaneous puncture-drainage, endoscopic and traditional surgery for acute destructive pancreatitis. The purpose of the work was to determine the management of patients, depending on ultrasonography and computed tomography of pathological changes of the pancreas The clinic treated 429 patients with acute pancreatitis. Of these destructive pancreatitis occurred in 96 (22,34 %) patients. 83 (86,46 %) patients underwent minimally invasive interventions (puncture and drainage under ultrasound navigation, laparoscopic drainage). The remaining 13 (13,54 %) patients underwent traditional intervention. The frequency of deaths was significantly lower in the group of patients with acute pancreatitis who underwent minimally invasive surgery. Selection surgical method in destructive pancreatitis should be determined on the basis of pathological changes to the pancreas and the surrounding tissue, detectable by ultrasound and computed tomography study. Optimal methods for the presence of liquid components are minimally invasive interventions under ultrasound navigation and laparoscopy.

The focus of the study was the general organization of crystal structures in the oral liquid in children (adolescents) aged 10-15, with optimal functional occlusion and dentofacial anomalies of varying severity. The item also offers a qualitative assessment of crystallograms as well as the respective quantitative processing of the crystallographic picture, which was done employing a specifically developed computer program. It was found that increased intensity of morphological and functional abnormalities in patients with malocclusion was accompanied with changes in quantitative (reduction of the radial area, protein-crystalline coefficient, structures formation intensity coefficient, combined with the increase of microcrystallization index) and qualitative (destructured crystals, oppression of crystallization sites, loss of stratification in the peripheral area) parameters of the oral liquid facies.

We performed a prospective analysis of endoscopic through the papillary interventions in our hospital from January 2008 to December 2012. The total number of patients was 1513 patients. Difficult cannulation cases marked by us in 607 patients (40,1 %). Men - 249 (41 %), women - 358 (59 %). The total number of completed through the papillary interventions in this group was 1887. We used almost the whole range of both diagnostic and therapeutic endoscopic through the papillary interventions used in biliary hypertension: endoscopic retrograde cholangiopancreatography (ERCP), endoscopic papillotomy (EPT), endoscopic mechanical lithotripsy and litho extraction (EMLE, EMLT) , nasobiliary drainage (NBD), biliary tract boogieing, biliary stenting, electrohydraulic lithotripsy (shock wave lithotripsy), biliary balloon dilatation. Our interventions were effective in 538 patients, which was 88,6 %. Ineffective our interventions were in 69 patients (11,4 %). Complications occurred in 33 patients (5,4 %).

Evaluation of the functional state of muscles is important in medico-biological provision of highly qualified athletes. Feature of swimming is a long-term training in water and physical training aimed at muscle development to overcome various distances in the shortest time. In the work carried out performance evaluation of anthropometry, physique, body composition and functional status of muscles of upper and lower extremities in athletes-swimmers. Systematic training for sport swimming increase muscle mass by 1,2 times, compared with persons not involved in sports, primarily due to the development of the muscles of the upper shoulder girdle and upper extremities and equal, but the specific distribution of fat mass in body composition. Have swimmers indices of aerobic capacity when working with the hands was higher in men 2,7, women have 3,3 times; for the feet of men and women is 2,3 times higher than in persons not involved in sports.

There was made analysis of the literature data, national and international consensus documents on various aspects of the diagnosis of thyroid nodules. For their differential diagnosis and assessment of malignancy risk, compression of the neck and mediastinum organs, development of functional autonomy it is used a wide arsenal of diagnostic methods. The leading method of determining the diagnostic tactics, is ultrasound. The use of ultrasound THIRADS classification allows to minimize the number of unwarranted needle biopsy without compromising the detection of malignancy in cancer risk groups. A differentiated approach to the choice of the diagnostic algorithm for each individual patient provides getting an accurate diagnosis, using minimum of time and resources, as the basis of choosing of the optimal treatment strategy.

We conducted a research of the following ways of the post-operative hypothyroidism treatment: CES-therapy, hormone replacement therapy with L-thyroxine and combination therapy including two previously suggested approaches. The usage of CES-therapy in postoperative hypothyroidism leads to a significant decrease of TSH, fT3 and fT4. On this background, signs of protein-synthetic failure are observed. The isolated usage of L-thyroxin leads to a significant increase in the content of fT4 with a decrease of TSH and close to normal values of fT3 while there are signs of an expressed activation of protein catabolism. It is shown that only a comprehensive application of CES-therapy and L-thyroxine leads to the increase of TSH concentration amid rising fT3 and fT4. Herewith there is an observation of protein-synthetic failure symptoms.

Work is executed on a clinical material of 118 patients, transferred the POP who has arisen as a result of scheduled (42) cases and emergency (76 cases) abdominal operations. It has been established, that pyoinflammatory complications after operation concerning the POP arise at 35,6 % of patients. The most informative method of diagnostics wounds complications at the POP was the US-control. Moderate increase of concentration of general antibodies IgA is revealed, IgM and IgG in 1,2-1,3 times norms at patients with the POP that is the major factor of forecasting and diagnostics of a progressing peritonitis and others PSC are higher. It is marked, that application of ways to take in full eventration and closings laparostomy improves results of treatment and reduces risk of occurrence of complications in the remote period.

One of the most main problems of medicine in 21th century is critical limb ischemia (CLI). From 500 to 1000 patients to 1 million of population have it, according many researches’ results. In our research we have made the analysis of two groups patients which had popliteal or calf arteries’ diseases. The first group was treated by balloon angioplasty, the second one was treated by therapeutical angiogenesis. The information, that were received during two years was analyzed. In the first group number of thrombosis was larger and a thrombosis was revealed in early stages. However, the amount of bad results was decreased and the term of patency was increased after a second operation. In the second group thrombosis of the stenotic artery of the tibia had place in later stages, what resulted in repeated therapeutic angiogenesis that was needed for evolving of microcirculation.

The article analyses bio-informational aspects in organization of reserve abilities of organism. The author gives an overview of the existing ideas about the role of bio-information in supporting vital resources of the organism and providing its existence while interacting with the environment. The article discusses the role of signal communication of organismic level in organization of adaptive reactions aimed at satisfying the needs of organism, including the formation of its functional reserves. Form the point of the theory of functional systems, it is logically grounded that functional reserves of organism can be considered as a dynamically self-regulating complex of informative elyinterrelated functional systems, whose multifaceted interaction provides the mobilization and recovery of the reserve abilities, in accordance with the vital needs of organism.

Experimental work conducted on Wistar rat line. Ischemia was simulated on the shin muscles of rats. Muscle ischaemia correction performed intragastric administration of pentoxifylline at a dose of 60 mg / kg of vardenafil dose of 0.9 mg / kg daily for 28 days and in combination vardenafil dose of 0.09 mg / kg of pentoxifylline and 30 mg / kg for 7 days. Results were evaluated 21 and 28 hours. The level of microcirculatory perfusion expressed in units. Correction of muscle ischemia combination of vardenafil and pentoxifylline in small doses for 7 days stimulates angiogenesis and improves blood circulation in the distal extremities in proportion to the average therapeutic dose of vardenafil 28 days.

The objective of study: to establish the possibility to identify the patients with cancer and its differential diagnosis with other tumor formation in the biopsies of uterus through visualizing glow in a high-frequency electric field. The Material and methods. There were 124 biopsies of uterus taken for histological analysis to observe malignant neoplasms and decide on the volume of surgical intervention. Visualization the glow of the biopsies of uterus was carried out in a high-frequency electric field. The results. According to histological analysis of 124 uterine biopsy samples 25 adenomyosis, 24 adenomatosis, 48 myomas and 27 uterine cancers were detected. Glow around the edges has been in high-frequency electric field in all studied biopsies. Inner glow was observed on the biopsy material, which there was a cancer tumor. The glow covered the entire area of cancer. The conclusion. These data about the luminous biopsies of the uterus in a high electric field can be the basis for creating endoscopic rapid method of uterine cancer of diagnosis.

Comparative evaluation of character of the expression of TLR9 and CD11b receptors by neutrophilic granulocytes and monocytes whole blood under the influence of Derinat and synthetic TLR9 ligand in healthy individuals and in acute infectious diseases of viral and bacterial origin has been studied. It has been shown that the unidirectional effects of study drugs relate changes in the number of neutrophils, carrying TLR9, and MFI CD289 in all groups, and monocytes only in groups with infectious process. Differently directed effects identified in relation to expression of molecules CD11b monocytes in all groups, and neutrophils in a group of healthy controls.

The study and treatment of 176 patients with postcholecystectomic syndrome that developed after removal of the gallbladder. According to information received cholecystectomy is the most traditional method of surgical treatment of traumatic, results and minilaparotomy cholecystectomy videolaparoscopic almost identical in the absence of contraindications should be recommended videolaparoscopic cholecystectomy. In 55.1 % of patients the cause of unsatisfactory results of cholecystectomy are diseases of non- hepatobiliary system. The availability and widespread adoption of the practice of minimally invasive surgery in biliary surgery often leads to unnecessary cholecystectomy, discrediting these advanced methods.

It was studied the state of hormonal levels in fertile and infertile patients with chronic prostatitis on a background of sexually transmitted infections (STIs). The study included 280 patients with chronic prostatitis, distributed into four groups: 70 fertile patients without STIs, 70 fertile patients with STIs, 70 infertile patients without STIs and 70 infertile patients with STIs. The control group consisted of 50 healthy men of reproductive age. It is revealed that in the group of infertile patients with chronic prostatitis with STIs, there are mixed changes in levels of sex hormones. In the group of fertile patients with chronic prostatitis a link between the level of sex hormones with the presence of STIs have been identified.

Local anesthesia is an integral component of medical procedures in today's children's dental practice. Enumeration of intraoral drugs containing anesthetics, for pediatric dentistry is extremely insufficient. Urgent is the development of children and of the dental gel containing trimekain, for application anesthesia. The purpose of this study was to study the adhesive properties of comparative gel compositions containing various combinations and trimekain potential of shaping. The studies revealed gel compositions with excellent adhesion characteristics, which can be recommended for further screening on the creation of children's dental gel trimecaine.

The article presents the main directions of the centers of health of the Republic Sakha (Yakutia). Emphasis is placed on ways to increase the level of activity centers in the area of prevention.

The aim of the study was to investigate the influence of allogeneic fibroblasts on during wound healing process in burn wound on the basis of cytology data. Achieved smear prints of burn in 14 victims of explosions of methane-coal mixture, which were treated in the Donetsk burn center in the period from 2009 to 2012. In the surgical treatment of these patients with extensive burns used cell culture allogeneic fibroblasts. It was found that the change of inflammatory type prints on the regenerator to the study site occurs at 7,14±0,61 days after escharectomy, the control - at 11,79±0,62 per day. Through the use of allogeneic fibroblasts after the escharectomy with deep dermal burns were able to prepare a wound to skin grafting 1,65 times faster when compared to standard methods of postoperative management of burn wounds.

In order to determine the amount of resection of the small intestine area child with necrotizing enterocolitis, the parameters of the emission in the high field section of healthy tissue biopsies were studied area with paranecrosis and necrosis of the small intestine. All biopsy specimens obtained edge emission (Kirlian effect). In areas paranecrosis and necrobiosis took place inside the fabric glow. At a later stage of necrosis inner glow disappeared. Brightness, wavelength range in the early stages of necrosis exceed those parameters when paranecrosis. It is the distinctive features in the assessment of small bowel segments.

We studied the correlation between quantitative and qualitative-governmental indicators for poisoning with ethanol on a background of alcoholic liver disease (110 cases). The positive and negative relation between the varying degree of alcohol content in the departments of venous and alkogolokislyayuschih activity of enzyme systems (AOFS) level alkogolemii and necro-inflammatory processes in the liver, morphological manifestations of poisoning with ethanol and the state AOFS. Revealed high negative correlation between the diameter of the portal vein, the number of blood vessels of medium caliber and the development of fibrosis.

Conducted comprehensive monitoring of pregnancy in 254 HIV-infected women of Krasnodar region with an average age at the time of taking the registration of pregnancy - 26,9 ± 0,3 years and gestational age 19,2 ± 0,5 weeks. The control group consisted of 116 pregnant women without HIV infection, randomized with a core group for age and pregnancy. In 220 (90,5 %) HIV-infected pregnant women diagnosed with latent CMV infection, primary - in 5 (2,1 %) and reactivate - in 18 (7,4 %). Equally often been infected with cytomegalovirus pregnant HIV-infected pregnant women without HIV infection (95,7 % and 96,5 %, Q≤0,5). Reactivate forms of CMV infection was significantly less often observed in pregnant women with HIV infection (7,1 % vs 27,6 %, Q≥0,5). The frequency of clinical forms of CMV infection compared with the age of HIV-infected pregnant women, with the duration and stage of HIV infection rates of HIV viral load and levels of CD4, anti-retroviral therapy, with the term of pregnancy, obstetric history. It was found that the incidence of CMV infection in pregnant women with HIV infection in process of a growing of patients, increasing the duration of HIV infection and the stage of its flow, more frequent multiplicity of pregnancy, reduce CD4+ T-lymphocytes, increase in HIV RNA. Reactivated forms of CMV infection was significantly more common in pregnant women with HIV infection at the lowest rates of CD4+ T-lymphocytes, maximal HIV viremia, delay in onset of perinatal antiretroviral prophylaxis. The frequency and variety of clinical forms of CMV infection in pregnant women with HIV infection do not depend on the well-being of obstetric history, as well as the number of co-ToRCH-infections.

The article presents the results of a content analysis of legislative and normative-legal documents of subjects of the SFD in the field of health and medicines to the orphan patients. The structure of the segment of the Federal Register of persons with rare diseases on SFD in accordance with ICD 10 and studied their age structure.

For the first time in the form of memorable dates in chronological order for the period from 1902 to 2014 years presents the main stages of development of specialized medical services Krasnodar psychiatric services available to residents of the city of Krasnodar, as their consumer.

Hailey-Hailey disease (HHD) is a rare cystic dermatosis, diagnosis and treatment are difficult. The article discusses the clinical features HHD in combination with multiple seborrheic keratosis (SK) on the background of insulin resistance of a 77 years old patient. Possible causes of the development of the SK are beeing discussed. The efficacy of topical and systemic antibiotic therapy was shown.

We report a case of recurrent parasagittal meningioma in a 61-year-old man. The disease was clinically manifested with general seizure and left hemiparesis. The result of the morphology was G1 meningioma. However, there were 2 recurrent tumors in the next 2 years. After the third surgery, the morphology shows atypical (G2) meningioma.

The article presents a clinical case with iatrogenic injury to the common bile duct after laparoscopic cholecystectomy and surgical treatment with the use of minimally invasive percutaneous techniques. The patient was admitted to the regional clinical hospital №2 of Krasnodar with iatrogenic injury to the common bile duct at ( 11 Bismush or (+1) Halperin), on the 3rd day after operation. Patient's health was hard, marked clinical manifestations a mechanical icterus syndrome and sys-temic inflammatory response syndrome. The patient performed ultrasound diagnosis of ab-dominal organs, laboratory blood tests. Patients showed signs of bile hypertension. We did per-cutaneous drainage of the bile ducts under the control of radiological methods as preoperative period. After 2 months, the patient made a planned reconstructive surgery - biliodigestive anas-tomosis Roux. There were not complications in the postoperative period. Literature review and difficulties of timely diagnosis, examination and minimally invasive treatment of these patients are showed.

Modern views of pathogenesis of tension type headache (TTH) have changed considerably over the past decades. The review presents the analysis of domestic and foreign sources reflects the base mechanisms of formation of TTH. The paper discusses the role of nervous, endocrinous, immune and vascular systems in forming of TTH. It shows that tension-type headache is a polygenic disease.

The problem of treatment of wounds accompanied mankind throughout its existence. The greatest challenge for physicians and patients are chronic wounds, especially among the elderly. The increase in life expectancy (from 65.34 to 70,76 l in the period from 2000 to 2013. Russia's average [26]) leads to an increase in older patients in hospital. According to the data of the City Hospital № 14 (St. Petersburg) the proportion of patients on surgical profile among patients treated was 46 %. This group is characterized by a wide concomitant somatic pathology. This requires the development of the most effective schemes and treatment aimed at reducing the length of hospitalization and improve the end-result of hospitalization. To do this, we had made a review of the literature on the treatment of wounds.

This article provides review of foreign literature on the problem of HPV-associated oropharyngeal cancer incidence. Epidemiological researches demonstrate increase of incidence of oropharyngeal squamous cell carcinoma (OPSCC) especially among white men of middle age. Such growth of oropharyngeal cancer incidence is associated with human papilloma virus type 16 (HPV 16). The p16 - protein expression is the marker of HPV DNA integration into human nuclear DNA. It is suggested that detection of tumor HPV-status can predict prognosis and develop preventive measures.