According to research statistics, the natural connection was established between diabetes and pathogenesis of the fundamental dental diseases. Disorders occurring in diabetes mellitus result in abnormal pregnancy and substantial deterioration of teeth and periodontal health. The rate of such dental pathology, as periodontal diseases and dental caries, increases and these diseases become more in diabetic pregnancy. Developing new methods of prevention and treatment of periodontal diseases and dental caries in pregnant women with diabetes mellitus remain an open problem in the modern stomatology.

Here, in this work, the peculiarities of secretion of steroid hormones have been researched in patients with gallstone disease depending on the course of the disease. It is suggested, that the lack of use of cholesterol for steroidogenesis leads to its precipitation in the composition of gallstones, increased cortisol is a limiting factor in inflammatory processes in the gall bladder. The increasing of testosterone synthesis may be considered as an antagonistic component of glucocorticoid regulation of lipid and protein metabolism.

The article presents the proper observing experience of lasting results of the endoscopic stenting in patients suffering from the malignant pathology of the biliopancreatoduodenal organs complicated by the bile duct obstruction. The functioning periods of different implant models have been analyzed in dependence of the tumour localization, the used materials and their implant configurations. Within the study it has been revealed that the service period of implants had significantly varied in patients having both the homogeneous pathology and implant characteristics. This was possible for us to substantiate the necessity of evaluation for the metabolic bile disorders, on basis of which it is possible to forecast the risks of lithogenesis and the service period for implants that by-turn allows us to optimize the algorithm of choosing an implant and also will leads to the increase in frequency of occurrences of their premature obstruction.

The article addresses the estimation of parameters of cellular and humoral immunity 130 white Wistar rats with experimentally reproduced by inflammation of periodontal tissues. The animals were experimentally simulated gingivitis, periodontitis, periodontal disease. Evaluation of the immune status of the rats showed that all parts of immunity change in varying degrees. The development of experimental inflammation of the periodontal tissues against the backdrop of changes in both cellular and humoral General immune status, is to reduce the content of total Mature T-lymphocytes (CD3+) and T-lymphocytes-helper cells (CD4+); increase of T-suppressors (CD8+) and decrease of the relative content of b-lymphocytes (CD20+). The use of glucosamine hydrochloride and chondroitin sulfate helps to normalize the cytokine profile leads to the relief of local inflammatory process, arising on a background of cytokine imbalance.

The students of medicine have been investigated for determination of their dental motivation level. A specially formulated questionnaire was used for this purpose. On the base of the students’ subjective opinions and preferences there were identified factors, influencing the level of motivation for dental treatment and preventive measures. It’s necessary to take into account psychophysiological characteristics and the age of the personality in dental motivation.

The paper shows the dependence of the degree of dysbiosis from the state of the local antioxidant defense system and local immune status in people with dysbacteriosis of the colon. There is a direct correlation of increasing degrees of severity of dysbacteriosis with the increase in the average number of gamma-interferon (γ-IFN), the cytokine index (CI), malonic dialdehyde (MDA) and an inverse correlation with the magnitude of the local antioxidant index (LAI). The definition of MDA, LAI, CI and γ-IFN in coprofiltrates can serve as additional methods of diagnostics of a dysbacteriosis and a selfassessment of microflora in the process of its correction.

The study describes the microbiological state of the patients with phlegmon of the maxillofacial scope. Most of the samples contained Staphylococcus aureus (52,63%). A lot of them produced beta-lactamase and were resistant to penicillin unprotected with inhibitors. Most effective antibiotics, tested during the study, were: azithromycin (90,24%), clindamycin (78,05%) and ciprofloxacin (75,61%).

There were examined 132 patients in the age of 29-77 years old. Morphological features of abnormal shape or position of gallbladder were detected at 26.9% of patients with undifferentiated connective tissue dysplasia, and this may contribute to the formation of gallstones.

The paper analyzes the results of diagnostics and comprehensive treatment offered to 47 patients (both sexes, the first period of mature age) with asymmetry of the dental arches and the same number of antimeres, in view of their individual parameters of the dentofacial region. For cases of full set of teeth the treatment was performed employing conventional orthodontic methods implying the use of removable devices of mechanical, functional and directing action, as well as non-removable equipment (edgewise technique). The comprehensive treatment tailored to the individual parameters of the dentofacial scope facilitated normalization of the shape of the dental arches and the occlusal relationships restoration.

The purpose of this work is to identify the relationship between concentration of progesterone in blood and stress healthy women. Material and methods. 52 healthy women aged 18 - 45 years were observed during the luteal phases of the menstrual cycle, undergoing examination in clinic “Yekaterininskaya”, in which ones progesterone was determined by immunochemiluminescent analysis of venous blood. Regulatory-adaptive status of the subjects was assessed by parameters of the sample cardiorespiratory synchronism before and after the stressor tests “Arithmetic account”. The level of stress resistance all observed the women were divided into three groups. In the high level of stress resistance - in the blood progesterone 7.0 - 21.0 ng / mL, with a moderate - 4.0 - 6.8 ng / ml and low - 1.7 ng - 3,8 / mL Conclusion. These data indicate that between kontsenentratsiey progesterone in the blood of healthy women and stress there is a connection: the more normative importance of progesterone in the blood, the higher the level of stress.

One of the main factors that reduce the period of use of fixed dentures is the reduction in the quality of the internal fit of the crowns to the tooth. Causes of invalid boundary clearance are different, in particular the violation of the art clinical and laboratory stages of prosthesis. Feature of orthopedic treatment is that the prosthesis is not a doctor, and a dental technician in the laboratory. In this link a doctor's office and laboratory is the impression prosthetic bed. One of the latest modern methods of obtaining the impression is the system volume intraoral scanning, allowing obtaining digital prints. The aim of this study was to study the internal fit of artificial crowns made on digital impressions obtained with intraoral scanner.

In the experiments on isolated circular segments of the thoracic aorta of a rat it has been proved that indole SS-66 derivative in 10-5 and 10-4 М concentrations can relax smooth muscle cells (SMS) due to its impact on the SMS potassium conduction thus facilitating their hyperpolarization. It results in the block of voltage-sensitive calcium channels, the decrease in calcium input and the SMS relaxing. Lack of the NO-synthase Nω-nitro-L-arginine blocker impact on this process indicates of the lack of the SS-68 impact on the processes connected with the endothelium-dependant SMS relaxation.

The results of study of characteristics of motives of activity, anxiety, depression, aggression and neurodynamical personality parameters in group of 72 healthy people and 148 patients with epilepsy with different effectiveness of modeling purposeful activity (test Gorbov-Shulte) are presented. The differences of these parameters in group of patients with different effectiveness of activity and quality of life was estimated. The higher level of anxiety, aggression and low level of social adaptation in group of patients with epilepsy determine approach of mobilizing pshychophysiological resources in realization of alternative biological models of activity which associated with higher frequency of seizures.

On the basis of the dental survey 2718 people (2432 men and 286 women) aged 18 to 27 years, of which 1112 men and 286 women contract servicemen (cadets of higher military educational institutions) and 1320 men - conscripts, set the frequency of occurrence of functional pathology mastication-speech apparatus - 9.9%. Temporomandibular joints pathology detected in 8.39% of the soldiers, masticatory muscles parafunction - at 6.73%. At conscripts, clinical signs of temporomandibular joints and masticatory muscles parafunction largely expressed than the military contract. In 52.79% of the soldiers had a combination of temporomandibular joints and masticatory muscles parafunction. It is noted that the prevention of and treatment of functional pathology of mastication, speech apparatus in young military personnel must provide during their clinical examination of occlusal rehabilitation, attraction to the treatment of clinical psychologist or therapist, as well as the regulation of the exercise.

In connection with the search for new treatments of acute odontogenic inflammatory diseases, the elaboration of easily reproducible, accurate models of this disease in rats is actual. In the experiment on rats, the model of acute apical periodontitis followed by histopathological research was reproduced. The computer radiovisiography was held on the 5th day. The sampling of jaw with an involved tooth was carried out on the 21st day of the experiment. On the computer radioviziogramme and obtained histological blocks the pattern of acute purulent periodontitis were verified. On the 21st day of our experiment in the adjacent to the tooth bone a clear pattern of osteomyelitis was revealed. The experimental model that was investigated is easily replicable, pathologically verified. Its course is accompanied by the elaboration of complications in the form of acute odontogenic osteomyelitis.

The aim of this paper is estimation aerobic and anaerobic working capacity of sportsmen under use of the complex program of metabolism optimization. Athletes of the main group (n=24) were tested on metabolism state with paid attention to antioxidant potential. These data were used for selection of individual complex of vitamins and antioxidants. In main group study of working capacity, including technologies of its estimation (veloergometry, gas analysis, investigation of maximal anaerobic power etc.) was executed before and after the course of this complex use. In control group (n=30) indicated testing was providing analogically. Our results have shown the positive action of directed optimization of the metabolism on parameters of aerobic and anaerobic physical capacity of sportsmen.

The aim of investignation. To study and to base scientifically the effectivity of clay therapy in the complex treatment of infertility on the phone of chronic non-specific salpingo-oophoritis in the patients, living in ecologically unfavorable areas. Materials and methods. Complex study of the main parameters of homeostasis was carried out in the 52 patients with chronic non-specific salpingo-oophoritis in the stage of remission, living in the ecologically unfavorable region of Vladikavkaz city. The treatment of the control group consisting of 25 patients was carried out by traditional medicamental therapy. The treatment of the main group (27 patients) was carried out with the use of clay «Tereklit» in 3 month after medicamental therapy. Results. The use of local curative clays of North Ossetia-Alania, supplies stable curative effect, allowing reliably fuller rehabilitation of reproductive health of patients.

The article presents an analysis of indicators of uteroplacental hemodynamics and outcomes of pregnancy of women with a threatened abortion in the early stages of pregnancy with the formation of a retrochorial hematoma. The increasing of the intensity of blood flow in the right uterine artery was found in pregnant women with retrochorial hematoma according to Doppler at 19-21 weeks of pregnancy. The blood flow appeared to be reduced in the left uterine artery at 19-21 weeks in pregnant women that occurred in 1 trimester retrochorial hematoma volume > 1 cm³. The analysis showed that pregnant women, who received dydrogesterone, and ones, who received micronized progesterone, had significantly elevated uteroplacental blood flow in the basin of the right uterine artery. There is significantly higher incidence of caesarean section in pregnant women who had the retrochorial hematoma volume >1 cm³ occurred in 1 trimester.

The article reflects the description of the modification method of manufacturing individual spoons and principles of functional impressions removal in patients and control group with complete loss of teeth in both jaws. A electromyografic (EMG) study of masseter and temporalis muscles in 38 patients in the comparative aspect. The obtained EMG results allow to assert that their qualitative characteristics are virtually identical to the description of the "norm". At the same time, given quantitative indicators vary significantly, and that is reflected in the improvement of the functional value of prostheses in patients of the main group a month after the prosthesis.

The article examines the existing methodical approaches to modeling of pathological conditions in pancreas, using the cryo-exposure on its tissue. Also the article analyzes a current concepts of pathophysiological processes underlying in local cryo-injuries of pancreas during of its experimental pathology modeling. The new concept of the role of ischemia -reperfusion injury of pancreas after cryotherapy on its tissue is proposed. Ischemic - reperfusion injury of the pancreas induced by deep cooling is considered as a trigger pathomorphological mechanism and identifying subsequent events and symptoms characteristic of acute pancreatitis.

The article presents preliminary results of the applications of the newly-developed collagen film coatings for the treatment of superficial burns. In all cases good tolerance was demonstrated with no side effects. Best results were achieved in case of the application of materials on early stages after receiving thermal injury.

This article provides an overview of the currently acquired information concerning the phenomenon of epithelialmesenchymal transition and its role in the formation of interstitial kidney fibrosis and the mechanisms of its development and possible points of application to produce a therapeutic effect. Particularly interesting in this respect was the transforming growth factor-ß apparently plays a key role in induction of epithelial-mesenchymal transition.

We have studied the levels of markers of collagen exchange 280 in infertile and fertile patients with chronic prostatitis. All patients were divided into 2 groups: group 1 - sterile (140 persons) and group 2 - fertile patients matched for age (140 people). The mean age of patients was 34 [22; 43]. The median disease duration was 6 [2; 4] years. The control group consisted of 50 healthy men of reproductive age. In the serum samples was carried out determining the level of transforming growth factor-β1 (TGF-β1), the level of C-terminal telopeptide of type I collagen (CTP) and carboxyterminal of propeptide of procollagen I (CAT). Revealed the effects of the fibrosis processes, as well as excess formation and degradation of collagen type 1 on the development of infertility in patients with chronic prostatitis. This conclusion was also confirmed by the results of the correlation analysis revealed the relationship between the presence of infertility and the level of TGF-β1 (r=0,61 p<0.001), CAT (r=0,64 p<0.001), CTP (r=0,31 p=0,021).

The fruits of Sophora japonica has long been successfully used as an antiseptic. However, despite the long period of application, the range of medicines produced from the fruit of Sophora japonica, has not changed and is still limited. One way to solve this problem is to implement a comprehensive recycling Sophora fruit. In this regard, the purpose was to study the possibilities of studies of complex processing them by the fruit of Sophora sequential extraction with extractants bipolar and antimicrobial activity of the resulting fractions with biologically active substances. It revealed that most rational for bipolar fractions of fruit of Sophora - potential drugs extractants use is as follows: 95% ethyl alcohol, 70% ethyl alcohol, purified water.

With the aim of increasing the effectiveness of early diagnostics and medical therapy of atrophic colpitis the valuation analysis of the kallikrein-kinin system and the activity of inducible NO-synthase in peripheral blood is carried out. 35 women (mean age 51±2.8 years) with moderate atrophy of the vagina was examined. A comparison group - 35 women (mean age 48 ± 3.6 years) without signs of atrophy and urogenital symptoms. The results of the study showed that in the serum of blood of women with symptoms of atrophic colpitis marked increase in the activity of kallikrein, decrease of prekallikrein level, inhibition of the inhibitory activity of α2-macroglobulin and recorded a sharp increase in the activity of inducible NO-synthase in clinical group of women that reflects the body's response on local disruption of the microcirculation. The results analysis testify about possibility of microcirculation local disturbances before clinical manifestations of the disease, that allow to diagnose of tissue degenerative changes in the shortest time with the use of additional laboratory method in the absence of clear clinical signs of the disease.

48 patients with various forms of chronic periodontitis before and after treatment were carried out sample cardiorespiratory synchronism, the index was calculated regulatory-adaptive status, as it was determined by the regulatory-adaptive capabilities of the organism. If any form of periodontal disease on the human body affects the pain factor. After his removal by the treatment of periodontitis regulatory and adaptive capacity increased. Thus, the regulatory and adaptive capacity of the body can serve as an indicator of the effectiveness of the treatment of periodontitis.

The work evaluated the regulatory-adaptive status in male students aged 18 to 21 years (60). The control group comprised persons of the same age, not specifically engaged in additional physical activity, but only in the framework of the curriculum (2 hours per week - 35 people). The main group consisted of students with enhanced physical activity, engaged in sports sections , with 25 people (volleyball, football, basketball, wrestling, track and field, swimming). The purpose of this study was to quantify the effect of exercise on the regulatory-adaptive status of the students. The results indicate a significant increase in regulatory-adaptive status in individuals with increased physical activity (index of the regulatoryadaptive status was made 104,16, and in the control group, 38.3 per). Increased physical activity in sports clubs has a positive effect on regulatory-adaptive status of the organism.

At 105 patients with paroxysmal and permanent form of atrial fibrillation against the background of coronary heart disease (CHD) and without CHD were studied concerning the levels of peroxidation products and protein-Lipid rows. The control group included 42 somatically healthy persons of Astrakhan region. In the course of studies there have been shown that the processes of peroxidation metabolism proteins and lipids in the blood of patients with paroxysmal and constant-atrial fibrillation characterized by a high frequency imbalance. The comparing of levels of products peroxidation proteins and lipids in patients with paroxysmal and persistent atrial fibrillation on a background of CHD and without CHD were detected with significant differences.

In experiments on anaesthetized cats in the sinoatrial node (SAN), located in induced high-frequency electric field, focus glow (FG) is visualized, which upon stimulation of the vagus nerve (VN) by periodic electrical impulses undergoes significant changes, characterized by FG weakening and its migration, the emergence of pacemaker cells odd pools (PCP); bradycardia and sinus arrhythmia are also observed. Intravenous indole SS-68 derivative (50 mkg/kg) injection which is included in III antiarrhythmic class and is M2 holinoblocator, causes the increase in the FG intensity, its returning to the original location, PCP combination, bradycardia relief and sinus arrhythmia arrest. Under vagal-cardiac synchronization (VCS), caused by VN volleys of electrical impulses stimulation, FG in SAN is intensified and increases its square. PCP are combining thus causing bradycardia. SS-68 (50 mkg/kg) intravenous injection does not cause visible changes in the SAN functional state. It is suggested that the lack of SS-68 activity under the experimental conditions is masked by the processes that occur in the SAN under VCS, that requires additional specific investigations.

Dynamics of disability of adult population owing to schizophrenia in the city of Krasnodar for 2000-2015 years and its correlation communications with indicators of activity of mental health service are considered in article. The greatest impact is exerted morbidness of schizophrenia of adult persons and active medical and preventive actions (augmentation coverage of patients with schizophrenia with hospitalization, decrease of stationary in a hospital among patients with schizophrenia, etc.). The obtained data can be used for planning of organizational medical actions and development of programs of medical and social rehabilitation.

The analysis of the frequency and character of clinical manifestations of herpes zoster in 287 HIV-infected pregnant women. The control group consisted of 116 pregnant women without HIV infection. It is shown that herpes zoster manifests only 1.0% of HIV-infected pregnant women, which was significantly less compared to pregnant HIV-negative (against 3,4%, Q = 0,5). Despite the fact that the clinical signs of herpes zoster occur in HIV-infected pregnant women against the background of immunodeficiency, herpes uncomplicated to moderate localized form, which may be related to anti-retroviral drugs.

The article is devoted to the peculiarities of diagnosis and treatment of fulminant myocarditis in young women. This clinical case confirms that etiopathogenetic complex therapy was implemented in a specialized Cardiac Intensive Care Department in conjunction with the necessary diagnostic and invasive procedures that are the optimal options for the diagnosis and treatment of patients with acute myocarditis.

The article contains, beginning with classical works and our own research, the information about various causes that lead to the occurrence of complications at various stages of prosthetics of the patients with fixed dentures. It gives the description of the complex of medical and orthopedic required protective measures aimed at leveling the side effects of medical manipulations during the production and use of metal-ceramic dentures. The advisability of the pulp vitality maintenance and the principles of its protection with minimal grinding of hard tooth tissue are underlined.

Though the biological activity of sodium dichloroacetate in medicine has been researched for the last forty-five years, our literature review is considered to be the first one in the domestic scientific literature and must draw the researchers' attention to this range of problems. During the clinic-experimental studies the effectiveness of sodium dichloroacetate as the cytoprotector in a number of pathological processes involving the mitochondrial dysfunction was researched as well as its antitumoral activity. The mechanism of its effect was associated with the activation of the pyruvate dehydrogenase complex and as a result of it the energy metabolism. In normal cells in the hypoxia conditions this leads to the optimization of oxygen consumption and the prevention of sulphur acidulation. In atypical cells this causes the metabolism inversion including the intensification of free-radical processes, the activation of caspase enzyme cascade, the activity lowering of proproliferative and proangiogenic transcriptional factors.