In the present research the changes in the enzyme link of the antioxidative system as well as in the content of reduced erythrocyte glutathione and the oral liquid in patients suffering from type II diabetes mellitus, bronchial asthma, chronic obstructive lungs disorder and comorbidities of the researched diseases have been disclosed. The regularities in changes of the biochemical indices on the systemic and the local level have been revealed. As a rule in patients suffering from the pathology comorbidities the more apparent metabolic disorders have been indicated. The most essential changes in the erythrocyte suspension have been revealed in patients suffering from all the pathologies found three. The activity of superoxide dismutase has increased by 29 %, of catalase by 65 %, of glutathione reductase by 2,4 times while the activity of glutathione peroxidase has decreased by 3,3 times. The glutathione concentration in the same patient group has been 19 % down from the control indices. In the oral liquid of the same group the activity of superoxide dismutase as well as the one of glutathione reductase has increased by 81 % and 83 % respectively. The activity of glutathione peroxidase has not changed, the activity of catalase has decreased by 9,2 times. In general, the indices of patients suffering from the comorbidities have been closer to the pathologies of the respiratory system which proves the conception of the leading role of oxidative disorders in such patients.

The study involved 360 patients and 112 obstetricians and gynecologists of the Rostov region. The survey method was used, thereafter statistical methods were applied. The level of awareness of patients about cervical screening, intraepithelial neoplasia of the cervix and the risk factors of its development is assessed as low. Experts wants to achieve two important goals through the use of medical decision-making support programs. The first and the most important of them is to improve the quality of early diagnosis of precancerous cervical disease. Computer programs can help to realize this desire through calculating of specific risk in numeral values. It can helps doctor in difficult clinical situation. The second potentially solvable problem is to improve patient’s compliance to treatment and examination after treatment.

The rapid implementation in practice of the method of intraosseous implantation greatly exacerbated the problem of bone tissue restoration after damage inflicted by dentists and put the choice of a reliable method of eliminating the existing bone defects. When jawbones atrophy observed morphological changes in the microcirculation vein, leading to disruption of metabolic processes in tissues and reduced their viability. As a result of conducted research we found that osteoplastic material Bio-Gene for reconstraction of the maxillary sinus bottom shows improvement of microcirculation that allows recommending it in broad dental practice, as well as laser doppler floumetry for full information in clinical conditions on the status of microcirculation in tissues of parodentium noninvasive technique.

Given the high rates of dental disease de children with neuropsychiatric disorders, there is a need to develop an algorithm to provide the necessary dental care. Embedded regulations "Multistep" represents "rehabilitation area" dental individualized care for children with neuropsychiatric disorders, in which the central place is occupied by the interaction of the child and the adult (the doctor and parents) in terms of medical and correctional environment, creating favorable conditions for the compensation of polymorphic disorders, dental adaptation full rehabilitation.

The results of the study cytoenzimechemical biologically research of neutrophilic granulocytes For an assessment of efficiency of medical manipulations after curettage of periodontal pockets Average degree weight of inflammatory process. Studying the dynamics of enzyme systems in peripheral blood neutrophils with a differentiated definition of cell populations hasn’t revealed a special difference of a cellular variety, a variation and an excess on the content and activity of enzymes oxidoreductases and hydrolases group in the structure of the cellular population which scatter data from predominances of cells with low activity to medium equilibration cellular pool with different functional activity. Asynchronous fluctuations enzyme systems affect the question of the pathogenesis of tissue induction and molecular mechanisms of differentiation process.

This paper analyzes the results of craniometrical and morphological studies of the temporomandibular joints of native products have been certified 58 skulls of people with physiological occlusion and a full set of permanent teeth, as well as with the included defects of dentition short-haul. The results of the research allow arguing that temporomandibular joint of an adult with physiological occlusion of the dentition has certain patterns, shapes and sizes, and clearly marked with the laws of the location of its structural elements.

The article presents first experience of balloon-assisted enteroscopy (BAE) for one year (from December 2015 to December 2016). The total number of patients was 19. In this group performed 28 balloon-assisted enteroscopy. Of these, 12 patients underwent oral BAE, 2 transanal and 14 combined. Diagnostic BAE was 18 and 10 operating. The article analyzes the main and concomitant diseases in this group of patients, the number and types of is operating and diagnostic interventions, their effectiveness. Analyzed further management of patients in the identification of surgical pathology. We present the most interesting clinical cases.

The display of the boundaries prosthetic bed is impossible without pushing the gingival margin. Manufacturers of dental materials today offer a wide variety of means for retraction: of yarns of different design and size, pastes, gels. Most often for these purposes, a retraction filament impregnated with various drug compounds. One of the new methods of taking impression is a system of digital three-dimensional scanning, allowing to obtain optical impressions. To study and analyze the quality of the retraction of the gingival margin using a variety of tools and methods to assess the magnitude of the horizontal and vertical retractions, you should use the system intraoral laser scanning. This article presents a technique for applying digital prints to explore the quality of the retraction of the gingival margin.

Results of clinical trial in article are presented. The conducted sociological survey of 100 doctors of stomatologistssurgeons (76 men and 24 women) aged from 29 to 45 years, an experience of professional activity not less than 3 years after completion of training in the internship or clinical internship working in municipal (30 people), departmental (24 people) and private dental clinics and offices (46 people) the motivational component to performance of an osteal plasty of jaws is studied, and also the factors constraining introduction of methods of an osteal plasty in municipal and departmental stomatologic out-patient and polyclinic authorities are established. It is established that in municipal, departmental and private out-patient and polyclinic authorities to surgical activity in this direction 73, 3 %, 79, 2 % and 95, 7 % of dentists that was caused generally by desire of salary increase, respectively or desire of professional body height, and also other factors, respectively. It is emphasized that only 14 % of doctors of stomatologists-surgeons gain necessary knowledge of questions of jaw osteal plasty when training (professional retraining, improvement, clinical internship) in HIGHER EDUCATION INSTITUTIONS. Need of updating of training programs and thematic plans on the chairs which are carrying out professional retraining, improvement and (or) training of dentists in clinical internship concerning a surgical dentistry and maxillofacial surgery is noted.

We analyzed ultrasound examination results in 231 patients retrospectively. The first control group included 30 patients. The second group consisted of 201 patients with focal alterations in thyroid gland. According to elastography results we performed fine-needle aspiration and cytology examination. Analyzing morphological outcomes we defined following groups: colloid goiter – 92, cellular goiter – 54, Hashimoto disease – 44, thyroid cancer – 11 patients. Rigidity index (kPa) in the control group was: Ме – 13,75, LQ-UQ – (11,63–15,97), minimal – maximal data – 6,17–22,2; Rigidity indexes of tissue nodes were distributed as follows: colloid goiter Ме – 15,33, LQ-UQ – (12,97–19,17), minimal – maximal data – 3,57–42,67; cellular goiter – 16,40, (12,87 – 19,1), (5, 57-34, 6); autoimmune thyroiditis- 24,77, (17,13–29,57), (10,13– 68,0); thyroid cancer – 48,78 (21,63–57,67), (13,67–60,0). Threshold level for malignant mass was 44,2 kPA. Diagnostic accuracy for Еmean date in the groupd with thyroid cancer was 84,2 %.

The aim of this study is to investigate the prognostic significance of the effect of the correction of modifiable risk factors (RF), cardio-vascular diseases (CVD) in the development of arterial hypertension (AH) using the methods of mathematical modeling.

Materials and methods. Surveyed population sample (2,189 people) of the adult population of rural areas of Krasnodar region (54.0 % women and 46.0 % men), mean age 47,72 ± 16,6 years (men – 46,27 ± 15,8 years, women – 48,95 ± 17,2 years). The study included patients with cardiovascular RF with the response 80, 1 % (n = 1006 people, of whom 43.2 % men and 48.3 % women, mean age 58,47 ± 13,7 years), who were re-examined every 3 years. Evaluation of anthropometric, clinical, laboratory, socio – demographic data. In order to correct cardiovascular RF, conducted in-depth preventive counseling (PC), individual and group. Statistical processing of the materials carried out using Statistica 6.10.1 and SPSS programs. Conducted a multivariate regression analysis of the proportional hazards (Cox model). Data are presented as M ± SD.

Results of the study. Hypertension (AH) significantly more often associated with 3 RF : smoking, unhealthy diet (UD) and obesity. The predicted risk of developing hypertension over a lifetime increases with age and was significantly higher in smoking patients, patients with a poor diet, and obese individuals. After PC among smokers the predicted risk of developing AH decreased by 13.0 %; a UD by 7.0 %; obesity is 7 %. The most common combination of RF associated with the development of AH: UD + (hypercholesterolemia) HC + smoking – 88.3 %; UD + HC – 74.6 %, UD + obese – 53.6 %.

Conclusion. The predicted risk of developing AH in their lifetime increased with age and was significantly higher in men: smoking, with UD, obesity. The effectiveness of preventive measures will significantly reduce the risk of developing AH.

While studying the expression of transcription, neoangiogenesis and apoptosis factors in the tumour tissue and oral fluid of 141 patients with oral mucosa cancer T1-3N0-2M0, it was shown that oral mucosa cancer progression combined with postoperative purulent inflammatory complications were associated with a high level of transcription factors, enhanced translocation of hypoxia-inducible factor-1б in the core, high expression of vascular endothelial growth factor and activation of apoptosis in the tumour tissue. The revealed changes in the underlying disease progression have a reasonably greater severity.

The study included 111 patients (40 men and 71 women) with connective tissue dysplasia in conjunction with insulin resistance or without one. The mean age was 30,8±3,1 years. The study group (n=69) included patients with connective tissue dysplasia in conjunction with R & D. The control group (n=42) included patients with isolated connective tissue dysplasia. The aim of the study was to investigate the effect of insulin resistance on connective tissue dysplasia. All patients were evaluated vegetative status by collecting complaints according to the questionnaire Wayne A.M. and counting Kerdo index. We analyzed the frequency of cardiac arrhythmias and conduction according to the rest electrocardiography, the frequency and severity of dysplasia of heart by echocardiography. It has been established that insulin resistance significantly is a burden to vegetative dysfunction syndrome, increases the frequency of sinus tachycardia episodes, of the interval-QT prolongation, ventricular arrhythmia, increases the frequency and severity of mitral valve prolapse I degree.

The connection of 21 clinical and social characteristics of individuals with central nervous system (CNS) in early childhood compared groups of patients and a group of healthy young men of military age and pre-conscription. The list of features we are interested in detecting link includes all the features related to traumatic brain injury (TBI). Variety of isolated signs in nature and content of the evidence of persons depending on the mental health of pre-conscription and conscription age with lesions of the CNS is in early childhood.

Purpose: to carry out pharmacoeconomic modeling for an early economic evaluation of the generic pegylated liposomal doxorubicin (PLD) drug.
Materials and methods: a Markov model and Decision tree model were developed to simulate and to compare the costs and effects of new generic PLD versus doxorubicin. Using the threshold criteria for economic value (willingness to pay threshold (WTP) for Russia), we determine value-based pricing for new generic PLD.
Results: pharmacoeconomic modeling can be used for an early economic evaluation of new medicines to determine value-based pricing for new pharmaceuticals and its financial impact on Russian health care system.

Medical-and-social characteristics as well as their connection with the health status of teenagers and young men below the conscription age and those due to conscription in the Krasnodar territory have been studied. The low level of their medical competence and prophylactic activity has been established. It was found necessary to plan priority guidelines for the improvement of medical support of these categories of the population as well as to create continuous system of hygienic education for social and age groups of young people.

483 postmenopausal women took part in survey. It was established that GG genotype and G allele of COL1A1 gene 1546 (6252) G>T [Sp1 S>s] polymorphism provide protective effect for osteoporotic changes development at L1-L4 lumbar vertebrae, forearm distal department, left and right femurs proximal departments, including femoral neck. GT genotype and T allele of above-stated polymorphism are postmenopausal osteoporosis predictors in various sites of skeleton. The obtained data can be used for detection of predisposition to osteoporosis development at postmenopausal women and treatment-and-prophylactic actions efficiency rising.

The analysis of the effectiveness of the use of certain elements of fast-track-surgery in the treatment of patients with acute surgical pathology, complicated widespread peritonitis. To this end, during the analysis, patients were divided into two groups: the first (control) assigned 35 patients (retrospective analysis of case histories), whose treatment was carried out in the normal way – surgery, adequate antibiotic therapy, conventional infusion therapy, analgesics. The second group (basic) – 35 patients whose treatment was supplemented by some elements of the fast-track-surgery. Clinical and laboratory evidence of accelerated recovery of normal intestinal motility, protein index lesser than the complications in the first group relative to the second. conclusion about the effectiveness of the elements can be made on the basis of the data fast-track-surgery in the treatment of patients with acute surgical pathology, complicated widespread peritonitis.

At this time there is a problem of protection of the population of blood, living in the zone of influence of gas chemical enterprises from the effects of the sulfur-containing gaseous pollutants, it remains relevant today. Therefore, For the first time it was studied the influence of the preparation «Etoxydol» on the absolute quantity of erythrocyte islets in the condition of sulfur dioxides impact on the different stages of ontogeny. As the toxic agent was applied industrial natural sulfurcontaining gas of the Astrakhan gas-condensate field. It was found that the use of the preparation «Etoxydol» against the background of intoxication gaseous sulfur pollutants leads to a relative normalization of the proliferation and maturation of erythrocytes at all stages of the studied ontogeny, which allows us to consider this preparation as an effective means of neutralizing the negative effects of this toxicants influence.

The article examines the characteristics of hemogram in children with various forms of acute appendicitis. It is conducting a study of 56 children aged from 7 to 14 years, as a result of which showed significant differences in the number of segmented leukocytes, lymphocytes, leukocyte index of intoxication by JJ Kalf-Caliph, as well as the heterogeneity of red blood cells in volume thrombocrit and mean platelet volume.

The paper studied the frequency of polymorphisms of hemostasis in patients with coronary heart disease, living in the Krasnodar region. Of the 13 patients with atrial fibrillation documented confirmed, 11 patients revealed mutations of genes of the hemostatic system (84.61 %), while 10 patients out of 11 had a mutation MTRR mutation (90.9 %), and met mutations in polygenic 10 cases (90.9 %). It is shown that the most common mutation MTRR gene, PAI, VII factor and beta fibrin often cause arrhythmias in patients enhance remodeling of the left ventricle, especially in polygenic mutations.

For the study of retinoprotective properties of pharmacological agents a model of retinal angiopathy of hypertensive type was created against the background of N-nitro-L-arginine methyl ester (L-NAME) administration in a dose 12.5 mg/kg rat body weight for 28 days. We studied the retinoprotective effects of minoxidil in a dose 0.5 mg/kg, sildenafil in a dose 0.5 mg/kg and distant ischemic preconditioning (DIP) on a model of retinal angiopathy of hypertensive type in Wistar rats. The experiment showed that minoxidil in a dose 0.5 mg/kg prevented the development of ischemic damage and retinal vascular changes of hypertensive type to a greater extent than sildenafil and DIP. The observed retinoprotective effects are confirmed by ophthalmoscopy, laser Doppler flowmetry (LDF). The lack of positive dynamics in experimental groups with the introduction of glibenclamide in a dose 5 mg/kg confirms the key role of ATP-dependent potassium channels in the mechanism of realization of preconditioning.

This study was conducted in order to evaluate the frequency of pulmonary hypertension in patients with ischemic cardiomyopathy and patients with postinfarction cardiosclerosis and preserved ejection fraction and to calculate the risk of its occurrence, depending on the severity of left ventricular-arterial interaction. Examined 130 patients with ischemic cardiomyopathy (mean age of 57,3±2,1 years) and 110 patients with post-infarction cardiosclerosis and preserved ejection fraction (mean age 56,1±1,7 years). All patients underwent Doppler echocardiography by standard method. The above data demonstrate the relationship between the level of systolic pressure in the pulmonary artery and the degree of impairment left ventricular-arterial interaction. Тhe risk of developing pulmonary hypertension as violations of the left ventricular-arterial interaction increases.

Demonstrated the results of prospective study of 661 patients were admitted in 17 hospitals of Krasnodar region with a diagnosis of acute coronary syndrome (ACS). Identify risk factors for cardiovascular diseases and medical history data were analyzed. The evaluation of diagnostic and therapeutic measures at different stages of care. Conclusions. Delivery times of patients with ACS in the hospital is not optimal. Outpatient therapy is insufficiently even after PCI and CABG. In the treatment of the hospital patients receive inadequate doses of antiplatelet agents. The proportion of patients who received reperfusion therapy should be increased. The use of invasive procedures for the diagnosis and treatment of acute coronary syndrome significantly improve outcomes and prognosis, with a low level of complications.

The urgency of developing a drug laxative action of grass harrow the field in the form of dry extract. The technology of dry extract of grass harrow using the method of vacuum filtration of extraction. A quantification of the active ingredients – phenolic compounds of a dry extract of grass harrow causing its laxative effect. The total content of phenolic compounds (isoflavones, flavonoids, phenolcarbonic acids) in phytopreparations harrow was about 25 %.

The scientific article contains a review of various methods of surgical treatment of follicular cysts of the jaws in children, both in the historical aspect, and in modern recommendations. Cases of 134 patients of Department of Maxillofacial Surgery of the Nizhny Novgorod Regional Children's Hospital evaluated the surgical techniques used in the clinic, viewed a permanent tooth preservation problem. There was made a conclusion about the indications for the choice of the surgical method, preservation rudiment of permanent tooth, and the necessity of early detection of follicular cysts of the jaws in children.

Carried out phytochemical analysis of plant materials: hibiscus flowers, fruits of hawthorn and wild rose. Suggested that the optimal composition of the composite syrup. Developed a rational technology of composite syrup. Recommended quality indicators: density, refractive index, quantitative content of anthocyanins. The retention period of the composite syrup – 1 year in vivo.

In the article presents the results of physical rehabilitation of patients with signs of connective tissue dysplasia and articular pain. As a result of exercises to strengthen the muscles of the back, marked bending strength increase and extension of the lumbar spine, rotation angles to the right and to the left, and their strength (the side muscles of the back), the power of flexion and extension of the cervical spine and muscle strength of the right and the left half of the neck and the decrease in the intensity of joint pain.

There were analyzed the results of 61 patients, age from 17 to 32, with epithelial coccyeal way in abscess stage who had been treated by method of precipitated radical treatment. The observed group consisted of 39 persons: 33 men, 6 women, in treatment of post-operative wound there was used the oxygenated nitrogen and regional lymphatic introduction of antibiotics and immunophan. In the comparative group (22) the post-operative wound was treated by ultrasound, the similar drugs were introduced by intramuscular method. The better quality of treatment was marked in the observed group.

The article presents data on the physical development disorders of children with different outcomes of perinatal brain lesions. The children, gone through neonatal reanimation, have different outcomes during postnatal development, they are: neurological deficit – 43,7 %, minimum cerebral dysfunctions (functional disorders) – 56,3 %. Physical development disorders were found in 58,2 % of children with neurological deficit and in 39,4 % of children with minimum cerebral dysfunctions (р<0, 05). The prevalence of underweight children was determined in children with neurological deficit (р<0, 001), and the prevalence of excess weight gain was noted in children with minimum cerebral dysfunctions (р<0, 05). Analysis of physical development was carried with using of the sigma deviations method. Analysis of psychomotor development was carried with using the Clinical Adaptive Test/Clinical Linguistic and Auditory Milestone Scale.

The article describes the little-investigated life and creative journey, the first organizer of the therapeutic Department of the Kuban medical Institute Professor N. N. Niyibizi (1876–1960).

Developing Dentistry is rooted in deep antiquity, from the time that all concerned by the question of getting rid of a toothache. The study of Russian and foreign literature of recent years in the databases of Scopus, Web of Sciences, PubMed about the main stages of development of dentistry. Identified stages of differentiation of dental science, shows the emergence of its independent sections. The characteristic of the main directions of research centers, their leaders and the academic schools. Thanks to the work done the way dentistry in our country in recent years has taken a great step forward. Restoring a complete picture of the formation of dentistry as a medical specialty will contribute to making the correct choice when searching for modern ways of further development.

The survey presents the existing arguments and facts about the parathyroid hormone-related protein (PTHrP) and its role in pathophysiological and pathobio-chemical mechanisms that are related to onco-transformation of prostate. The para-thyroid hormone-related protein is a multipotent molecule, whose proteolytic proc-essing results in the development of smaller biologically active peptides that par-ticipate in the regulation of survival, proliferation and differentiation of cells, in different normal and pathologically changed tissues. The parathyroid hormone-related protein is produced by prostate cancer cells and many other tumors. The au-thors put their special attention to biochemical basis of mechanisms that cause ef-fects related to parathyroid hormone-related protein at patients with prostate can-cer. The survey covers the question of how the parathyroid hormone-related pro-tein participates in modulation of phenotypic developments of the onco-transformation if its tissue, as well as its role in formation of local and whole or-ganism reactions in response to the prostate cancer treatment. The main attention was devoted to the influence of the parathyroid hormone-related protein on the key effects in the development of cancer in natural conditions. The final remarks reflect the existing and potential possibilities to use the modern knowledge about the para-thyroid hormone-related protein in the clinical practice on the prostate cancer for the diagnostic purposes, as well as the targets for the anticancer therapy. The survey presents the data on the structure, biochemical characteristics and multifaceted role of this protein in the organism. The main part of the survey contains information about the different aspects of participation of the parathyroid hormone-related protein in development of the prostate cancer, in its metastasizing, the role in development of hormoneresistance, effect on apoptosis in prostate can-cer cells.

Treatment of purulent disease and traumatic lesion of skin and soft tissues are associated with a formation of vast tissue defects. Successful early regeneration of skin cover makes favorable outcome of the disease and social rehabilitation of patients. In these days specialists are taking interest in dosed skin expansion method (DSEM) again for vast wound defect closure. Literature data were analyzed by us concerning biophysical and pathogenetic justification of using DSEM. Received data provide reasoned prerequisites to an elaboration of modern innovative methods for solving a problem of wound defects closure in purulent surgery and trauma and injury surgery.