Aim. Retrospective analyses of organization and effective providing medical aid to patients with uncomplicated unhospitalized hypertensive crises (300 cases) is made according to informational base of complex automatic system under the control of Krasnodar Medical Emergency service.

Material and Methods. Drugs with various activities such as captopril, moxonidine, nifedipine, urapidil, propranolol were used as hypertensive agents. Hypotensive effect was estimated every 15 to 30 minutes according to the level of systolic and diastolic blood pressure decreasing, heart rate falls and improvement of common condition.

Results. Moxonidine and urapidil proved to have the most evident hypertensive properties. When the Medical Emergency service goes for a call about hypertensive crisis, it is recommended to use as antihypertensives moxonidine and urapidil in individua ldoses.

Conclusion. However, the time spent on calls doesn’t allow full control for the rate of blood pressure decreasing in the course of several hours. The creation of unified emergency aid informative base with outpatient-clinical net makes it possible to observe the patients under control in the emergency aid departments and to improve succession in various stages of providing medical aid.

Aim. The article discusses the evaluation of the effect of 3-month therapy of angiotensin-converting enzyme fosinopril and angiotensin II receptor antagonists valsartan on the clinical manifestations of CHF, hemodynamics and morphofunctional parameters of the heart, taking into account the function of the right ventricle and systolic pressure in the pulmonary artery in patients with ischemic heart disease Postinfarction cardiosclerosis in combination with type 2 diabetes.

Material and Methods. 69 patients with IHD PICS, complicated by CHF II-III FC in combination with type 2 diabetes, were under observation. Patients were randomized into 2 groups: the first group consisted of 35 people taking fosinopril with an average daily dose of 20 mg, the second group consisted of 34 people taking ARS II valsartan at an average daily dose of 80 mg. Initially and after 12 weeks of treatment, all patients underwent a clinical examination, including clinical assessment of CHF manifestations, office blood pressure measurement and ECHR.

Results. The appointment of ACEI and ARA II, led to an improvement in the clinical state of patients and the expansion of the functional capabilities of the myocardium.

Conclusion. It should be noted that, without any particular advantages, in the effect on heart remodeling processes, fosinopril administration had a more pronounced effect on the systolic function of the left ventricle, and the use of valsartan significantly improved the diastolic function of the left ventricle.

Aim. Study of SS-68 impact on primary generalized convulsions in basic estimation tests of anticonvulsant action of agents.

Material and methods. Study of the SS-68 impact on primary generalized convulsions included an estimation of anticonvulsant action with maximal electric shock, thiosemicarbazide and pilocarpine antagonism tests performed on white outbred male mice and rats.

Results. SS-68 compound possesses dosage dependent anticonvulsant action in maximal electric shock test indicating its ability to prevent death of 100% animals and its activity in thiosemicarbazide and pilocarpine antagonism tests as well. In the maximal electric shock test SS-68 surpassed sodium valproate in its anticolvulsant activity.

Conclusion. Neurotransmitter systems of the brain such as GABA, cholinergic and amino acid stimulant system as well as K+, Na+ and Ca2+ channels of neurons shall be the most possible molecular targets of SS-68 anticonvulsant action. Higher activity of SS-68 comparing with sodium valproate in the maximal electric shock test (increasing GABA content in central nervous system) can be related with its wide range of neurotropic action.

Aim. To study the impact of work environment and occupational factors on the development of neoplasms in chemical workers of the Republic of Bashkortostan.

Material and Methods. Analysis of occupational cancer morbidity rate in certain chemical sectors within last 45 years was made using archive data.

Results. A number of chemicals affecting workers of manufactures under discussion are carcinogens and they initiate the development of oncopathology among workers. Occupational cancer diseases in the structure of occupational diseases in diverse manufactures amount for 6,5 - 12% of cases. Main nosologic forms were leukoses, hyperkeratosis, skin blaqstoma, lung and bronchial cancer. Categories of risks for neoplasms among workers were within medium to very high (intolerable) limits.

Conclusions. In the manufacturing processes of organic synthesis and fiberglass, there are a number of chemicals of carcinogenic type. A portion of occupational cancer diseases in organic synthesis manufacture amounts for 6,5%, in continuous fiberglass - 12% exceeding ten times All-Russian indicators.

Aim. To explore ocular microcirculation in patients with intraocular hemorrhage.

Material and Methods. Microcirculation was investigated in 26 patients after subtotal posterior vitrectomy with the use of a laser blood analyzer LAK-01 and a computer program to carry out spectral analysis of the signal. Statistical processing of the results was performed using AnalystSoft software package, BioStat 2007.

Results of the study. Ocular microcirculation in the control group was characterized by high levels of blood perfusion and metabolic activity, symmetrical distribution of arterial inflow and venous outflow. Evaluation of microcirculation parameters in patients with intraocular hemorrhage demonstrated a significant fall of these figures.

Conclusion. Surgical removal of intraocular hemorrhage leads to a signficant improvement of ocular microcirculation.

Aim. To assess sodium hypochlorite water solution anti-scolex activity against Echinococcus granulosus protoscolexies and effect on secondary echinococcus cysts envelopes.

Material and methods. We preformed two in vitro trials of the sodium hypochlorite water solution 0.06%, 0.12%, 0.25%, 0.5%, 1%, 2% and 4%. Sodium hypochlorite water solution anti-scolex activity versus exposure and the concentration of the drug was assessed in the first trial. Two drops of sodium hypochlorite water solution of various concentrations were added to the drop of the echinococcal fluid with living protoscalexes. The morphological changes of the parasite were investigate with a light microscope with a 100X magnification. The death of protoscolexes occurred within the first minute after the addition of sodium hypochlorite water solution, irrespective of solution concentration. The effect of sodium hypochlorite water solution on the secondary Echinococcus granulosus cysts envelopes was evaluated in the second trial. Envelopes fragments of the secondary echinococcal cysts were placed in tubes with sodium hypochlorite water solution in different concentrations. The changes were evaluated macroscopically. The envelopes of the secondary echinococcal cysts were completely dissolved in all tubes with sodium hypochlorite water solution.

Results. The experimental data have showed that sodium hypochlorite water solution is an effective anti-scolex medication enabling completely dissolution of the secondary echinococcal cysts envelops.

Conclusions. Considering that sodium hypochlorite is thoroughly investigated and safe for human body, sodium hypochlorite could be “ultimate” anti-scolex medication, enabling extension of indications and ad value for less invasive percutaneous interventions under radiation control in echinococcosis.

Aim. Clinical and epidemiological characteristics of influenza in the Krasnodar Territory for 2016.

Material and methods. The article uses the results of the monitoring of the circulation of influenza viruses from the Federal budgetary establishment of public health services Center for Hygiene and Epidemiology in the Krasnodar Territory in 2016, as well as the clinical features of influenza according to the reports of the Specialized Infectious Diseases Hospital of the Ministry of Health of the Krasnodar Territory for the same period.

Results. It was demonstrated that prevalence in the circulation of the influenza strain in the Krasnodar Territory during the year 2016 was A (H1N1) pdm09, the content of which was 96.0%, less frequent influenza A (H3N2) – 2.0% and influenza B – 2.0% . Analysis of the intensity of influenza immunity showed a high percentage of seropositive persons against the influenza B virus (99%), a smaller proportion to the virus A (H3N2) – 40.0% and to the virus A (H1N1) pdm09 – 36%. The hospitalized incidence of influenza and its dynamics are estimated, the characteristics of the clinical course of influenza during the reporting period with details of complications, frequency and causes of deaths are given.

Conclusion. The increase in the number of influenza patients who received inpatient treatment in 2016 as compared to 2015, the rarity of erroneous referral diagnoses, prevalence in the structure of patients with moderate disease, complications in the form of community-acquired pneumonia, which determined the death rate 1.1%, was underlined.

Aim. Anatomic variations of a structure of the anterior part of the mandible with account of gender for the characteristic of the internal structure of bone tissue and specification of the topographical features of the inferior dental canal for obtainment of osteal material for an autoplasty of an alveolar process (part) of jaws are presented in the article.

Material and methods. In the course of a clinical-anatomic research performed at 600 men and 600 women aged from 18 up to 55 years the specific anatomic features of a structure of the mandibular mental region were studied. 20 non-identified skulls (10 male and 10 female) with mandibles at the background of partial loss of teeth with various types of the mental region and the mandible sections at the level of apexes of the canine and the central incisors roots for comparative evaluation of morphometric research data and visual identification of the inferior dental canal on the anatomic material and 3D pictures were also studied.

Results. Studying of the specific anatomic features of a structure of the mental region of the mandible allowed to allocate 5 types of an anatomic structure of the mental region (spherical or spheroid; oval or ellipsoidal; wedge-shaped or "acute"; rectangular; flat) taking into account gender differences. The internal structure of the bone tissue of the mental region and the specific features of the inferior dental nerve endings location after a foramen were evaluated.

Conclusion. The highest amount of compact substance was observed in the wedge-shaped and rectangular types of the mandibular mental region.

Aim. Was evaluated clinical results of transluminal balloon angioplasty (PTA) in patients with critical ischemia, depending on the opening ratio of crural arteries and restore blood flow in the arterial arch of the foot.

Material and Methods. Results of treatment of 63 patients with critical limb ischemia, who underwent technically successful transluminal balloon angioplasty (PTA).

Results. Clinical success was 79.4%, and was statistically significantly associated both with the opening ratio (p=0.01), and with the restoration of blood flow on arterial arch of the foot (p<0.001). The number of small and large amputations in the case of restoration of arterial arch of the foot was significantly less (p<0.001). The filling of the arc via peroneal artery provide a clinical result comparable to the result of revascularization of the foot through one of the main arteries of the tibia (p=0,18).

Conclusion. Clinical success of the procedure associated with the technical features of the PTA is conducted as with the restoration of the arc, and with the number of "open" arteries of the lower leg.

Aim. The aim of the study is to analyze special aspects of medical assistance to the rural population of Krasnodar Krai.

Material and methods. A study conducted on the basis of the statistics, including information on the achievement of specific targets of socio-economic development of the Kurganinskiy district, analysis of indicative plans for socio-economic development of rural settlement Temirgoevskaya of Kurganinskiy district.

Results. The rural health underresourcing was revealed: remoteness of settlements from specialized medical organizations, low staffing level of health institutions by physicians (46.7%), paraprofessionals (72.1%), nonconformity of wages level with the target values (200% from the median wage for the district for doctors while the current value is 165% and 100% for secondary and nursing staff with the current values of 84% and 73% respectively). For leveling the staffing problems in the district a subprogram “Healthcare system staffing”, which is a part of a program “Healthcare development”, a focused program “Medical personnel for rural healthcare”, a program "Zemsky doctor", etc. are implemented. For medical assistance approaching its onsite forms are used and telemedicine network is developing as well.

Conclusion. The rate of mortality and increase of life expectancy so far do not meet those necessary to achieve the efficiency factors, although they are showing a positive dynamics. A high level of socio-economic stability of the residents of Kurganinskiy district and Temirgoevskaya settlement can be the factors of health maintenance. Reducing diseases incidence and increasing life expectancy, we provide productivity growth and extension of the working period of those employed in the agricultural sector that ensures the growth of national income and enhancing its well-being.

Aim. To assess the efficacy of minimally invasive procedures to improve the results of surgical treatment of nonparasitic liver cysts.

Material and methods. The experience of treatment of 42 patients with nonparasitic liver cysts is presented, technical aspects and efficacy of minimally invasive methods in this category of patients are described.

Results: using of an endovideosurgical method of treatment significantly reduces the time spent in hospital, minimizing postoperative complications. Long-term results of surgical treatment of nonparasitic liver cysts in the form of good cosmetic effect, absence of recurrences of the disease and clinical manifestations were improved.

Conclusion. A laparoscopic treatment of nonparasitic liver cysts is characterized by the low number of complications, low frequency of relapses, and the absence of necessity for re-operation. The use of external drainage for nonparasitic liver cysts under the ultrasound supervision is preferable for infectious complications of liver cysts as a first stage before the radical surgical treatment.

Aim. To study the association of polymorphic locus rs1138272 of GSTP1 gene with the risk of bronchial asthma and peculiarities of its course.

Material and Methods.136 DNA samples of patients with bronchial asthma of varying severity and 147 healthy persons DNA sample were used for genotyping by polymerase chain reaction and restriction fragment length polymorphism.

Results. We found the association of allele Val of polymorphic locus rs1138272 of GSTP1 gene with the severity of bronchial asthma and violation of external respiratory function, which is a prognostically unfavorable sign for the course of the disease. No significant skewing in the distribution of alleles and genotypes was seen between the patients and controls.

Conclusion. In this study we revealed the association of polymorphic locus rs1138272 of GSTP1 gene with an increased risk of severe bronchial asthma.

Aim. The study of Dimephosphon impact on survival of the dermal graft on the pedicle and the fasciocutaneous autograft in the arterial, venous and arteriovenous deficiency on the background of the experimental diabetes mellitus complicated by exogenous hypercholesterolemia.

Material and Methods. In experiments on white rat males with Alloxan diabetes complicated by exogenous hypercholesterolemia the Dimephosphon effect was estimated for survival of the dermal graft on the pedicle (in the back area) and non-free fasciocutaneous autograft (of the anterior abdominal wall) in arterial, venous and arteriovenous circulation deficiency. To estimate dermatoprotective action of Dimephosphon the length the survived dermal draft part and the necrotic area of the non-free fasciocutaneous autograft were measured. In blood serum the glucose rate (by glucose oxidant method with a standard “Glucose-FKD” (Russia) reagents set ), as well as the total cholesterol , triglyceride, high-density lipoprotein cholesterol rate (by “Olmex” standard reagent sets on the FP-901 (Finland) analyzer ) were measured. Extralow and low density lipoprotein cholesterol and also atherogenicity index were calculated with common formulas.

Results. Under accepted experimental conditions Dimephosphon (100mg/kg per day subcutaneously within 14 days) has well-defined dermatoprotective action as well as correcting effect on carbohydrate and lipid metabolism.

Conclusion. Dimephosphon dermatoprotective action can be provided by its ability to be involved in various parts of homeostasis including carbohydrate and lipid metabolism.

Aim. The aim of our work was the analysis of the methods and results of surgical treatment and prevention of post-burn scar contractures of the neck in children and adults in Krasnodar Krai.

Material and methods. Analysis was made of the treatment of 43 patients aged from 2 to 58 years who were treated in the Burn Department of the Research Institute – Regional Clinical Hospital №1 named after Professor S.V. Ochapovsky in 2006–2016.

Results. Children underwent plastics by local tissues mostly (64%), and adults – free skin plastics (55,6%). A direct result of the treatment was removal of the contracture and restoration of the neck skin. The early results from 1 to 11 months inclusively, were analyzed in 21 (84%) child and 12 (66,7%) adult patients. The remote results were followed up in 13 (52%) pediatric patients in a period of 1 to 10 years, in 8 (44,4%) adult patients in terms from 1 to 4 years.

Conclusion. Dissection and excision of the cicatrices simultaneously allows radically elimination of cicatricial deformity of the neck. The nature of the cicatricial skin lesions, the degree of contracture and the presence of cicatricial changes of adjacent areas tissues determine the way of the plastic closure of the wound.

Aim. Pperform a comparative analysis of the content of markers of bone metabolism in the oral fluid in pregnant women without dental pathology and complications of the gestational period in comparison with healthy donors in the dynamics of the gestational period.

Material and Methods. 31 pregnant women (clinical group) were examined. The control group consisted of 32 non-pregnant women. In the oral fluid and serum, the level of activity of alkaline phosphatase (AP), the content of osteoprotegerin (OPG) and receptors for the ligand of the nuclear factor kappa-B (sRANKL) was determined by an enzyme immunoassay.

Results. The index evaluation of the hygienic state of the oral cavity, periodontal conditions, confirmed the absence of inflammatory changes and dental pathology in patients of the clinical group. In pregnant women with a physiologically pregnant pregnancy, OPG, AP (markers of restriction of osteoresorption) accumulated to the third trimester both systemically and in biological fluids of the oral cavity.

Conclusion. The content of sRANKL during the gestational period in the oral fluid did not change. The study of the content of OPG and AP in the oral fluid in pregnant women is informative, reflecting the osteosynthetic processes of bone metabolism in the alveolar processes.

Aim. Analysis of complications arising in the process of fragmentation of the lens nucleus, by various methods the energy of the impact in the surgical treatment of age-related cataracts.

Material and methods. The study included 550 patients (677 eyes) operated for cataract in the period from 2015 to 2017 in the Krasnodar branch of the S. Fedorov Eye Microsurgery Federal State Institution. According to the method of energy crushing of the lens nucleus, all patients were divided into 3 groups. For group 1 – ultrasound technology (bimanual phacoemulsification of cataract (FCE) was used; for group 2 – Nd: YAG-laser with a wavelength of 1,44 μm technology of laser cataract extraction (LCE) was used; group 3 – infrared femtosecond laser technology (femtosecond laser support phacoemulsification (FFCE) was used.

Results. When using FFCE minimum percentage of complications in comparison with the FCE and LCE in cases of uncomplicated age-related cataracts was observed. In has been proved that in the presence of complicated cataracts, combined with a defect or weakness of the ligamentous apparatus of the lens, a pronounced syndrome, irido-ciliary dystrophy (IFIS-syndrome), bad expanding pupil; as well as in cataract with high degrees of density of nuclei, and in agitated patients, both FCE and LCЕ can be used. In our opinion LCE is preferable.

Conclusion. Differentiated approach to the choice of the optimal method of phacofragmentation results in minimum intra – and postoperative complications, as well as better outcome for the patients.

Aim. To study the cardioprotective effects of exenatide and vildagliptin on the doxorubicin model of cardiomyopathy.

Material and methods. In the experiments at the isolated the Langendorff heart of the rat, the cardioprotective effect of exenatide (10 μg/kg/day) (Baeta®, Eli Lilly and Company, USA) and vildagliptin (0.2 mg/kg/day) (Galvus®, Novartis, Switzerland), on the contractile function of an isolated heart that underwent anterior doxorubicin (20 mg/kg, intraperitoneally for 48 hours) pathology was evaluated. Cardioprotective effect was assessed by the results of a functional test with highfrequency stimulation (480 bpm) under conditions of hypercalcium (5 mmol) perfusion.

Results. The results show that the exenatide (10 μg/kg/day) and vildagliptin (0.2 mg/kg/day) incretin mimetics show a cardioprotective effect on the doxyrubicin pathology model, which is expressed in a decrease in the coefficient of diastolic dysfunction (StTTI), respectively, to 5.3±0.1 cu and 6.5±0.2 cu compared with the control group 8.3±0.1 cu.

Conclusion. An assumption is made about the way of realization of the cardioprotective effect of incretin mimetics by increasing the expression of gem-oxygenase-1 (HO-1). This prevents the heme-catalyzed formation of highly active hydroxyl radicals from hydrogen peroxide. Induction of heme oxygenase-1 is accompanied by an increase in ferritin activity, which has an antiapoptotic effect due to the fact that ferritin binds excess free iron in cells subjected to oxidative stress.

Aim. To study the sorption activity of enterosorbent based on montmorillonite under the laboratory cipher of Crim_04 against E.coli enterotoxin in vivo.

Material and Methods. Isolated loops of the small intestine were formed in laboratory rats under anesthesia, and E. coli toxin was injected into the control loops at a dose of 2 μg/loop. The enterosorbent under the code Crim_04 in the form of water suspensions with concentrations of 50 mg/ml, 100 mg/ml and 200 mg/ml was injected into the lumen of the loops with toxin. After 4 hours, the expression of the fluid in the lumen of the intestine and its inhibition by the enterosorbent were evaluated. Comparison was Smekta.

Results. The introduction of toxin into the lumen of the gut caused an increased fluid yield, the dilatation index for the control loops was 112,7±1,2 mg/cm versus 27,4±0,4 mg / cm in intact loops. The enterosorbent under the Crim_04 cipher exhibited a dose-dependent inhibitory effect on the fluid outlet into the lumen of the gut, at a concentration of 200 mg/ml, the dilation index was 31,6±0,8 mg / cm, inhibiting the fluid yield by 95,1%. This effect is confirmed morphologically, the morphometric parameters when using enterosorbent under the Crim_04 cipher are close to the level of intact loops.

Conclusion. The montmorillonite-based enterosorbent under the laboratory cipher Crim_04 has a high sorption activity against the thermolabile cholera-like E. coli enterotoxin on the isolated bowel loop model.

Aim. Create an algorithm predicting the risk of development of paroxysmal atrial fibrillation in patients with coronary heart disease on the background of post-infarction cardiosclerosis (PICS).

Material and Methods. There was conducted the deep analysis of a number of laboratory and functional indicators (indicators of peroxidation of proteins, lipids, antioxidant protection and skin microcirculation) at 85 patients with atrial fibrillation (AF). All patients were divided into 4 groups: patients with paroxysmal and chronic AF without PICS (27 people), patients with paroxysmal and chronic AF with PICS (12), patients with permanent AF without PICS (26) and patients with permanent form of AF with PICS (20).

Results. There was created the mathematical model to predict the development of atrial fibrillation in patients with PICS with calculation of the odds ratio of atrial fibrillation. Methods of correlation and factor analysis revealed the greatest value for the prognosis of paroxysmal atrial fibrillation in patients with PICS two factors: the total level of deep oxidation products of protein and an indicator of microcirculation by laser Doppler flowmetry. The diagnostic sensitivity of the developed prognostic model was 86%, specificity of the test – 94%, the diagnostic efficiency of the test – 90%.

Conclusion. The study has been proven clinical diagnostic and prognostic value of a comprehensive study of indicators of oxidation-reduction reactions, and the microcirculation indices in combination with standard laboratory and instrumental investigations in patients with AF. The developed mathematical model allows to predict the development of atrial fibrillation in patients with PICS.

Aim. Assessment of professional competences of pharmaceutical professionals in pharmaceutical and basic medical knowledge and development of methodical approaches to improving the process of pharmaceutical counselling of pharmacies visitors.

Material and Methods. Systematic and integrated approaches, logical, comparative analysis, statistical, sociological methods were applied.

Results. Research was conducted among 500 pharmaceutical specialists of Nizhny Novgorod Oblast, working in retail pharmaceutical organizations, during which they evaluated their professional competence in the field of pharmaceutical and basic medical knowledge. In the result, it was found that only about a quarter of specialists has pharmaceutical and medical knowledge and is capable of making comprehensive recommendations. Developed algorithm and a standard operating procedure counselling on the example of the choice of means of conservative therapy and prevention of varicose disease of the lower limbs (without ulcers and inflammations).

Conclusion. The low level of professional training of pharmaceutical specialists in the field of pharmaceutical counselling was observed, a method of increasing the effectiveness of the implementation of counselling options among pharmacists.

Aim. To give the morphological characteristic of scarring tissue of the surgical wound closed with the prolonged flow aspiration drainage (PFAD) of subcutaneous tissue and without it.

Material and methods. The study involved 40 outbred rabbits (20 in the main group, 20 in the control one). Histomorphological evaluation of tissue blocks of surgical wounds of the anterior abdominal wall, taken on the 15th, 20th, 25th and 30th post-surgery days, was carried out.

Results. Formation of granulation tissue and scarring of wounds of the animals in the main group, to which PFAD of subcutaneous tissue was applied, occurred alongside less destructive inflammations. The free space, on the place of a removed flowing drainage of the surgical wound, was gradually filled with granulation tissue, and then with the cicatricial one; and by 25 – 30 days after surgery it merged with the total cicatricial mass, without leaving any free cavities.

Conclusion. PFAD of subcutaneous tissue of surgical wounds promotes favorable regeneration and less complicated post-surgery period in comparison with the surgical wounds closed in the traditional layer-by-layer tight way.

Aim. Improving diagnosis of premorbid skin changes of gas production employees.

Material and methods. 158 employees of male Astrakhan gas processing plant aged from 28 up to 59 years (on average 40,23±0,49 years) which didn't have at the time of survey the demonstrative forms of the somatic and neurologic diseases and 77 clinically healthy volunteers of control group who were constantly living to Astrakhan aged from 25 up to 55 years are examined (on average 38,18±0,99). Average length of service at the enterprise made 9,02±0,29 years. Assessment of a functional condition of a skin by method of laser Doppler flowmetry was carried out on the laser analyzer of a capillary blood flow (LAKK-01) (NPP Lazma, Moscow).

Results. The analysis of hemodynamic types of microcirculation showed that at gas processors disturbances of a peripheric circulation in a skin, and in superficial vessels more expressed, than in deep took place. Most often in all vessels of a skin of brushes and in deep layers of a skin of forearms the hyperemic type, mainly with blood stasis signs in capillaries and stagnation in a post-capillary link was registered.

Conclusion. Frequent registration of the phenomena of a stasis of a blood can demonstrate formation of a mikroangiopatiya almost at a third of employees of the plant under the influence of factors of production medium.

Aim. To conduct an analysis of the management of innovation activities for innovative medicines market launch in Russia and abroad.

Material and Methods. The methods of cognition (including methods of empirical (observation, comparison) and theoretical research (analysis, synthesis, aggregation)), expert assessments, SWOT analysis were used in the research.

Results. The analysis of domestic and foreign experience in planning and regulating research in the field of pharmaceutics is carried out. Despite the fact that at present a powerful ramified state apparatus for regulating scientific research and development in the field of medicine has been formed in the Russian Federation, the pharmaceutical science remains divided. This leads to a decrease in the effectiveness of research in the field of pharmaceuticals. At the same time, in developed countries, interdepartmental coordination and advisory bodies (councils, commissions) are active, often at the highest level. This testifies to the high attention given in these countries to interdepartmental interaction and intersectoral projects in the field of research and development.

Conclusion. Foreign R & D support systems are characterized by a number of differences from domestic mechanisms. A number of recommendations based on the experience of foreign colleagues for future measures to modernize existing and introduce new mechanisms for state support of research in the field of pharmaceuticals in Russia are proposed.

This article examines the historical aspects of the creation of pharmacy organizations in the Don from the beginning of the 18th century. The development of the pharmaceutical business of our region is associated with the names of the great men of the time: in the villages of the Don Cossacks – the Empress Elizabeth, troop Ataman Platov; Taganrog – Catherine the Great and Alexander I; Rostov-on-Don – the Emperor Nicholas II. Social and economical environments of that time, geographical position and climate had an influence on it . It was found that during the 200 years of pharmacy service on the Don, pharmacy workers, along with trading activities, engaged in charity, prevention and first aid.

Aim. To carry out literature analysis devoted to the studies of the importance of peripheral blood neutrophils and monocytes in the pathogenesis and diagnosis of inflammatory bowel diseases, namely Crohn's disease and ulcerative colitis. Blood neutrophils and monocytes, as the main components of the inflammatory infiltration of the intestinal wall, are the sources of inflammatory mediators, pro-inflammatory cytokines, involved in the mechanisms of the mucous membrane destruction. Change of these blood cells intracellular enzymes activity using cytochemical methods can indicate the activity of the systemic inflammatory process, which reflects the activity of this process in the intestinal wall, and make possible prognosis of the disease course.

Conclusion. Further study of the dynamics of the functional activity of blood neutrophils and monocytes will make possible design of diagnostic algorithms for inflammatory bowel diseases and assess the effectiveness of the therapy.

Aim. To analyse the modern concepts of neuromuscular and joint dysfunction. The article presents the current notion of parafunctional violations of masticatory muscles associated with the loss of teeth, anomalies and deformations in the dento-facial system. We touched the issues of functional overload of periodontium on the background of muscle hypertrophy and related infringement of proprioceptive impulses, which are based on the change of coordination, rhythmic of chewing movements and kinetics of the temporomandibular joint.